林詠峯(Lin, Yung-Feng) 副教授

Email
yflin@tmu.edu.tw
現   職
服務學習中心 主任
醫學檢驗暨生物技術學系 副教授

學經歷

學 歷

畢業學校與學位[修業時間]
Wayne State University生化暨分生學系 博士
2001/09~2006/12
中山醫學大學醫學研究所 碩士
1999/09~2001/06
中山醫學大學醫技系 學士
1990/09~1994/06

本校學術經歷

任職單位與職稱[起迄時間]
醫學檢驗暨生物技術學系副教授
2015/08/01~
醫學檢驗暨生物技術學系助理教授
2011/02/01~2015/07/31
醫學檢驗暨生物技術學系(舊)助理教授
2010/06/14~2011/01/31

本校行政經歷

服務單位與職稱[起迄時間]
服務學習中心主任
2020/01/01 ~
醫學生物科技博士學位學程籌備處助理教授
2015/02/01 ~

其它經歷

任職單位與職稱[起迄時間]
EMORY 大學人類遺傳學系博士後研究員
2007/03~2010/02
Wayne State 大學研究助理
2001/08/22~2007/02/28

專長與研究領域

學門領域
生物化學 (Biochemistry)
分子生物學 (Molecular Biology)
細胞毒理學 (Cell Toxicology)
神經科學 (Neuroscience)
細胞生物學 (Cell Biology)
寄生蟲學、醫事技術及實驗診斷
學術專長
Gene cloning, mutagenesis, expression and regulation
ICP-Mass Spectrometry
HPLC
FPLC
UV/Vis and fluorescent spectroscopy
Protein purification and structure/function analysis
French press
Subcellular fractionation
Immunohistochemistry
Yeast two-hybrid analysis
Co-immunoprecipitation
Mouse care, behavioral studies
Mouse CSF collection

論文著作

清冊下載


1. 2020 Shieh JC,Huang PT,Lin YF. Alzheimer’s disease and diabetes: insulin signaling as the bridge linking two pathologies . Molecular Neurobiology .2020 ;(In Press)

2. 2019 Tsai YF,Yang DJ,Ngo TH,Shih CH,Wu YF,Lee CK, Phraekanjanavichid V, Yen SF, Kao SH, Lee HM, Huang VS, Shieh JC, Lin YF. Ganglioside Hp-s1 Analogue Inhibits Amyloidogenic Toxicity in Alzheimer's Disease Model Cells . ACS Chem Neurosci .2019 ;(10):528-536

3. 2019 Hsu LH,Chu NM,Lin YF,Kao SH. G-Protein Coupled Estrogen Receptor in Breast Cancer . Int. J. Mol. Sci .2019 ;(20):306

4. 2019 Chokchaiwong S,Kuo YT,Hsu SP,Hsu YC,Lin SH,Zhong WB, Lin YF, Kao SH. ETF-QO mutants uncoupled fatty acid β-oxidation and mitochondrial bioenergetics leading to lipid pathology . Cells .2019 ;(8)

5. 2019 Liao TL,Lee YC,Tzeng CR,Wang YP,Chang HY,Lin YF, Kao SH. Mitochondrial translocation of estrogen receptor β affords resistance to oxidative insult-induced apoptosis and contributes to the pathogenesis of endometriosis . Free Radic Biol Med .2019 ;(In Press)

6. 2019 Ting LL,Lu HT,Yen SF,Ngo TH,Tu FY,Tsai IS, Tsai YH, Chang FY, Li XJ, Li S, Lee CK, Kao SH, Kuo YM, Lin YF. Expression of AHI1 rescues amyloidogenic pathology in Alzheimer’s Disease Model Cells . Molecular Neurobiology .2019 ;(56):7572-7582

7. 2019 Hsu LH,Feng AC,Soong TC,Ko JS,Chu NM,Lin YF, Kao SH. Clinical outcomes of chemical pleurodesis using a minocycline . Therapeutic Advances in Respiratory Disease .2019 ;(13)

8. 2019 Sheu JJ,Yang LY,Sanotra MR,Wang ST,Lu HT,Kam RS, Hsu IU, Kao SH, Lee CK, Shieh JC, Lin YF. Reduction of AHI1 in the serum of Taiwanese with probable Alzheimer’s disease . Clinical Biochemistry .2019 ;(76):24-30

9. 2018 Lin CY,Sheu JJ,Tsai IS,Wang ST,Yang LY,Hsu IU, Chang HW, Lee HM, Kao SH, Lee CK, Chen CH, Lin YF. Elevated IgM against Nε-(Carboxyethyl)lysine-modified Apolipoprotein A1 peptide 141-147 in Taiwanese with Alzheimer’s disease . Clinical Biochemistry .2018 ;(56):75-82

10. 2015 Chao PZ,Hsieh MS,Lee FP,Chen SY,Chen CW,Chang HW, Lin YT, Ting LL, Lin YF, Chen CH. Serum level of interleukin-21 is elevated in chronic rhinosinusitis . Am. J. Rhinol. Allergy .2015 ;(29):1-6

11. 2015 Yang SF,Hsu HL,Chao TK,Hsiao CJ,Lin YF,Cheng CW. Annexin A2 in Renal Cell Carcinoma- Expression, Function and Prognostic Significance . Urol Oncol-Semin Ori Investig .2015 ;(33):22e11-21

12. 2015 Chao PZ,Hsieh MS,Cheng CW,Hsu TJ,Lin YT,Lai CH, Liao CC, Chen WY, Leung TK, Lee FP, Lin YF, Chen CH. Dendritic Cells Respond to Nasopharygeal Carcinoma cells through Annexin A2-Recognizing DC-SIGN . Oncotarget .2015 ;(6):159-170

13. 2015 Huang PT,Chen CH,Hsu IU,Salim SA,Kao SH,Cheng CW, Lai CH, Lee CF, Lin YF. Huntingtin-Associated Protein 1 Interacts with Breakpoint Cluster Region Protein to Regulate Differentiation . Plos One .2015 ;(10):e1-e13

14. 2015 Lu HT,Hsieh MS,Cheng CW,Yao LF,Hsu TY,Lan Jai, Kim KY, Oh SJ, Chang YH, Lee CH, Lin YF, Chen CH. Alterative effects of an oral alginate extract on experimental rabbit osteoarthritis . Journal of Biomedical Science .2015 ;(22):64-1-64-8

15. 2015 Chen CY,Lin YS,Chen CL,Chao PZ,Chiou JF,Kuo CC, Lee FP, Lin YF, Sung YH, Lin YT, Li CF, Chen YJ, Chen CH. Targeting annexin A2 reduces tumorigenesis and therapeutic resistance of nasopharyngeal carcinoma . Oncotarget .2015 ;(6):26946-26959

16. 2013 Lu HT,Sheu MT,Lin YF,Lan J,Chin YP,Hsieh MS, Cheng CW, Chen CH. Injectable hyaluronic-acid-doxycycline hydrogel therapy in experimental rabbit osteoarthritis . BMC Vet Res .2013 ;(9):68-79

17. 2013 Weng L,Lin YF,Li AL,Wang CE,Sun M,Gaertig MA, Mitha N, Kosaka J, Wakabayashi T, Xu X, Tang B, Li S, Li XJ. Loss of Ahi1 Affects Early Development by Impairing BM88/Cend1-mediated Neuronal Defferentiation . J Neurosci .2013 ;(33):8172-8184

18. 2013 Chao PZ,Chin YP,Hsu IU,Liu CM,Yu YC,Leung TK, Lee YJ, Chen CH, Lin YF. Apoptotic Toxicity of Destruxin B in Human Non-Hodgkin Lymphoma Cells . Toxicol in Vitro .2013 ;(27):1870-1876

19. 2012 Cape A,Chen X,Wang CE,O'Neill A,Lin YF,He J, Xu XS, Yi H, Li H, Li S, Li XJ.. Loss of huntingtin-associated protein 1 impairs insulin secretion from pancreatic β-cells. . Cell Mol Life Sci. .2012 ;(69):1305-1317

20. 2012 Chang CC,Hsieh MS,Liao ST,Chen YH,Cheng CW,Huang PT, Lin YF, Chen CH. Hyaluronan regulates PPARγ and inflammatory responses in IL-1β-stimulated human chondrosarcoma cells, a model for osteoarthritis . Carbohydrate Polymers .2012 ;(90):1168-1175

21. 2012 Yang HC,Fu HL,Lin YF,Rosen BP. Pathways of arsenic uptake and efflux . Curr Top Membr. .2012 ;(69):325-358

22. 2011 Chao P.Z.,Hsieh M.S.,Cheng C.W.,Lin Y.F.,Chen C.H.. Regulation of MMP-3 expression and secretion by the chemokine eotaxin-1 in human chondrocytes . J Biomed Sci .2011 ;(18):86-86

23. 2011 Chen TL,Lin YF,Cheng CW,Chen SY,Sheu MT,Leung TK, Qin CH, Chen CH.. Anti-Inflammatory Mechanisms of the Proteinase-Activated Receptor 2-Inhibiting Peptide in Human Synovial Cells. . J Biomed Sci. .2011 ;(18):43-50

24. 2010 Wang KC,Lin YF,Qin CH,Chen TL,Chen CH. Bisphenol-A interferes with Estradiol-Mediated Protection in Osteoarthritic Chondrocytes . Toxcol Lett .2010 ;(198):127-133

25. 2010 Xu X,Yang H,Lin YF,Li X,Cape A,Ressler KJ, Li S, Li XJ. Neuronal Abelson helper integration site-1 (Ahi1) deficiency in mice alters TrkB signaling with a depressive phenotype . Proc Natl Acad Sci U S A .2010 ;(107):19126-19131

26. 2010 Lin YF,Xu X,Cape A,Li S,Li XJ. Huntingtin-associated protein-1 deficiency in orexin-producing neurons impairs neuronal process extension and leads to abnormal behavior in mice . J Biol Chem .2010 ;(285):15941-15949

27. 2008 Sheng G,Xu X,Lin YF,Wang CE,Rong J,Cheng D, Peng J, Jiang X, Li SH, Li XJ. Huntingtin-associated protein 1 interacts with Ahi1 to regulate cerebellar and brainstem development in mice . J Clin Invest .2008 ;(118):2785-2795

28. 2007 Lin YF,Yang J,Rosen BP. ArsD: an As(III) metallochaperone for the ArsAB As(III)-translocating ATPase . J Bioenerg Biomembr .2007 ;(39):453-458

29. 2007 Lin YF,Yang J,Rosen BP. ArsD residues Cys12, Cys13, and Cys18 form an As(III)-binding site required for arsenic metallochaperone activity . J Biol Chem .2007 ;(282):16783-16791

30. 2006 Lin YF,Walmsley AR,Rosen BP. An arsenic metallochaperone for an arsenic detoxification pump . Proc Natl Acad Sci U S A .2006 ;(103):15617-15622

31. 2002 Wong MD,Lin YF,Rosen BP. The soft metal ion binding sites in the Staphylococcus aureus pI258 CadC Cd(II)/Pb(II)/Zn(II)-responsive repressor are formed between subunits of the homodimer . J Biol Chem .2002 ;(277):40930-40936

32. 2002 Tsai KJ,Lin YF,Wong MD,Yang HH,Fu HL,Rosen BP. Membrane topology of the p1258 CadA Cd(II)/Pb(II)/Zn(II)-translocating P-type ATPase . J Bioenerg Biomembr .2002 ;(34):147-156


1. 2017 Yang DJ,Tsai YF,Lin YF. Testing ganglioside analogs in Alzheimer’s disease model cells . The 3rd Faculty of Health Sciences International Conference .2017

2. 2016 Yen SF,Wu YC,Ngo HT,Lin YF. Abelson Helper Integration Site- 1 in Amyloid Precursor Protein Processing . Teachers and Students Joint Academic Research Symposium, Taipei Medical University .2016

3. 2016 Tsai IS,Tsai YH,Chang FY,Lin YF. Investigation of Huntingtin- Associated Protein-1 and Its Related Proteins in Neurodegeneration in Mice . Joint Annual Conference of Biomedical Science, Taipei, Taiwan .2016

4. 2015 Ngo HT,Lin YF. Alteration of Abelson Helper Integration Site-1 in Alzheimer’s disease model cells . 2015 Teachers and Students Joint Academic Research Symposium, Taipei Medical University .2015

5. 2014 Lin YF,Yang LY,Hsu IU,Tsai YH,Chang FY,Wang ST, Sheu JJ. Abelson Helper Integration Site-1 as a Biomarker for Alzheimer's Disease . 15th International Union of Biochemistry and Molecular Biology .2014

6. 2014 Chen CY,Tsai MT,Yang LY,Liao CC,Lin YF. The Effects of Gallium in Liver Cancer Cells . 2014 生醫年會 .2014

7. 2013 Yang LY,Chen CY,Hsu IU,Lin YF. Investigation of Huntingtin-Associated Protein 1-related Biomarkers in Alzheimer's Disease . 2013海峽兩岸檢驗醫學論壇 .2013

8. 2013 Salim SA,Li XJ,Lin YF. Identification of Potential Markers in Huntingtin Associated Protein-related Nervous Diseases . 2013 Taiwan Proteomics Society International Conference .2013

9. 2012 Hsu IU,Salim SA,Li XJ,Lin YF. Identification of Potential Markers in Huntingtin Associated Protein-related Nervous Diseases . 2012海峽兩岸檢驗醫學論壇 .2012

10. 2011 Hsu IU,Li XJ,Peng JM,Chen CH,Lin YF. Huntingtin-associated protein-1 in microtubule proteome . 2011 Merck Millipore Asia Bioforum .2011

11. 2009 Lin YF,Xu X,Li S,Li XJ. Selective Loss of Huntingtin Associated Protein-1 (HAP1) in Orexin Neurons Leads to Abnormal Feeding and Locomotor Behavior . Neuroscience 2009 .2009

12. 2008 Lin YF,Xu X,Sheng G,Li S,Li XJ. Interaction of huntingtin associated protein 1 (HAP1) with AHI1, a proetin involved in Joubert syndrome . Neuroscience 2008 .2008


1. 2019 臨床生化學 . 華格那企業 .2019

2. 2012 Yang HC,Fu HL,Lin YF,Rosen BP. Pathways of arsenic uptake and efflux . Curr Top Membr .2012 ;(69):325-358

研究計畫

計畫名稱
108 評估ENERGI對阿茲海默症模型小鼠的疾病預防與療效
補助單位
華安醫學股份有限公司

計畫名稱
107 人參莖、葉萃取物對阿茲海默症模型小鼠的療效評估
補助單位
科技部

計畫名稱
107 丹淨系列產品草本萃取液之肝臟保健與調節呼吸道發炎相關機能成分鑑定研究計畫
補助單位
鈞生股份有限公司

計畫名稱
106 邀請Georgia State University Eric Seth Gilbert副教授,於107年05月07日至107年05月08日止來台訪問一案
補助單位

計畫名稱
106 邀請Florida International University Barry Philip Rosen教授,於107年06月25日至107年06月30日止來台訪問乙案
補助單位
科技部

計畫名稱
105 以阿茲海默症模型細胞篩選與評估醣苷神經鞘醯胺衍生物之藥效
補助單位
科技部

計畫名稱
105 亨丁頓關聯蛋白與阿伯爾森幫手整合位點蛋白的交互作用在乙型類澱粉引起的神經退化中之角色
補助單位

計畫名稱
104 醫學檢驗暨生物技術學系林詠助理教授向本部申請邀請University of Illinois Simon Silver教授,於104年11月15日至104年11月23日來台訪問乙案,本部同意補助其在台生活費
補助單位
科技部

計畫名稱
104 亨丁頓關聯蛋白調控的囊泡運輸相關之神經退化疾病生物標誌
補助單位
科技部

計畫名稱
103 神經退化疾病中漢丁頓關聯蛋白調控之鈣離子運輸失調的機制
補助單位
科技部

計畫名稱
102 神經細胞中漢丁頓關聯蛋白緩解乙型類澱粉引起的神經退化之機制
補助單位
臺北醫學大學附設醫院

計畫名稱
102 探討神經退化疾病中漢丁頓關聯蛋白調控的生物標誌
補助單位
行政院國家科學委員會

計畫名稱
102 探討神經退化疾病中漢丁頓關聯蛋白調控的生物標誌
補助單位
科技部

計畫名稱
101 漢丁頓關聯蛋白相關的神經存活標誌之研究
補助單位
行政院國家科學委員會

計畫名稱
100 腫瘤細胞對鎵的調節機制
補助單位
臺北醫學大學附設醫院

計畫名稱
100 與漢丁頓關聯蛋白相關的神經疾病之標誌物篩選與鑑定
補助單位
行政院國家科學委員會

計畫名稱
100 抗增生性鎵化合物的細胞標的和抗藥性研究
補助單位
臺北醫學大學

計畫名稱
99 小鼠漢丁頓關聯蛋白在微小管依賴性運輸中之角色
補助單位
行政院國家科學委員會

計畫名稱
99 漢丁頓關聯蛋白-1(HAP1)在微小管依賴性運輸上之功能探討
補助單位
學校