王紋璋(Wang, Wen-Chang) 副教授

Email
wangwc@tmu.edu.tw
現   職
轉譯醫學博士學位學程 副教授

學經歷

學 歷

畢業學校與學位[修業時間]
中央大學數學系 博士
1999/09~2003/12
中央大學數學系 碩士
1994/09~1996/06
中央大學數學系 學士
1990/09~1994/06

本校學術經歷

任職單位與職稱[起迄時間]
轉譯醫學博士學位學程副教授
2018/08/01~
轉譯醫學博士學位學程助理教授
2012/09/01~2018/07/31

本校兼職教學行政經歷

服務單位與職稱[起迄時間]
國際轉譯科學博士學位學程籌備處副教授
2020/05/01 ~
醫學資訊研究所副教授
2019/11/01 ~
臨床藥物基因體學暨蛋白質體學碩
2013/08/01 ~

其它經歷

任職單位與職稱[起迄時間]
國家衛生研究院協同研究員
2011/10~2012/08
國家衛生研究院技術師
2010/02~2011/10
國家衛生研究院博士後研究員
2004/02/17~2010/02/16

專長與研究領域

學門領域
生物統計
學術專長
Genetic linkage and association analysis
High-throughput genomic data analysis
Statistical computing

論文著作

清冊下載


1. 2020 Wong JYY,Zhang H,Hsiung CA,Shiraishi K,Yu K,Matsuo K et al.. Tuberculosis infection and lung adenocarcinoma: Mendelian randomization and pathway analysis of genome-wide association study data from never-smoking Asian women . Genomics .2020 ;(112):1223-1232

2. 2020 Chien LH,Chen CH,Chen TY,Chang GC,Tsai YH,Hsiao CF, Chen KY, Su WC, Wang WC et al.. Predicting lung cancer occurrence in never-smoking females in Asia: TNSF-SQ, a prediction model . Cancer Epidemiology, Biomarker, & Prevention .2020 ;(29):452-459

3. 2020 Senghore T,Chien HT,Wang WC,Chen YX,Young CK,Huang SF, Yeh CC. Predictive value of genetic variants XRCC1 rs1799782, APEX1 rs1760944, and MUTYH rs3219489 for adjuvant concurrent chemoradiotherapy outcomes in oral squamous cell carcinoma patients . Pharmacogenomics Journal .2020 ;(20):813-822

4. 2020 Senghore T,Wang WC,Chien HT,Chen YX,Young CK,Huang SF, Yeh CC. Association of XRCC2 rs2040639 with the survival of patients with oral squamous cell carcinoma undergoing concurrent chemoradiotherapy . Gene .2020

5. 2019 Thomas Senghore,Huei-Tzu Chien,Wen-Chang Wang,You-Xin Chen,Chi-Kuang Young,Shiang-Fu Huang, Chih-Ching Yeh. Polymorphisms in ERCC5 rs17655 and ERCC1 rs735482 Genes Associated with the Survival of Male Patients with Postoperative Oral Squamous Cell Carcinoma Treated with Adjuvant Concurrent Chemoradiotherapy . Journal of Clinical Medicine .2019 ;(8):33-z

6. 2019 Senghore T,Wang WC,Chien HT,Chen YX,Young CK,Huang SF, Yeh CC. Polymorphisms of Mismatch Repair Pathway Genes Predict Clinical Outcomes in Oral Squamous Cell Carcinoma Patients Receiving Adjuvant Concurrent Chemoradiotherapy . Cancers .2019 ;(11):598-z

7. 2019 Wu CM,Su FH,Wang WC,Lin CP,Kamiza AB,Chang SN, Yeh CC. Association of chronic hepatitis B virus infection with age-related macular degeneration . Acta Ophthalamologica .2019

8. 2018 Kamiza AB,You JF,Wang WC,Tang R,Chang CY,Chien HT, Lai CH, Chiu LL, Lo TP, Hung KY, Hsiung CA, Yeh CC. Polymorphisms of Xenobiotic-Metabolizing Genes and Colorectal Cancer Risk in Patients with Lynch Syndrome: A Retrospective Cohort Study in Taiwan . Environmental and Molecular Mutagenesis .2018 ;(59):69-78

9. 2018 Wang YJ,Chen KY,Kuo LN,Wang WC,Hsu YW,Wong HSC, Lin CM, Liao KH, Zhang YF, Chiang YH, Chang WC. The association between BDNF Val66Met polymorphism and emotional symptoms after mild traumatic brain injury . BMC Medical Genetics .2018 ;(19):13-yyy

10. 2018 Hu YC,Yeh CC,Chen RY,Su CT,Wang WC,Bai CH, Chan CF, Su FH. Seroprevalence of hepatitis B virus in Taiwan 30 years after the commencement of the national vaccination program . PeerJ .2018 ;(6):e4297-yyy

11. 2018 Wu MH,Luo JD,Wang WC,Chang TH,Hwang WL,Lee KH, Liu SY, Yang JW, Chiou CT, Chang CH, Chiang WF. Risk analysis of malignant potential of oral verrucous hyperplasia: A follow-up study of 269 patients and copy number variation analysis . Head & Neck .2018 ;(40):1046-1056

12. 2018 Yeh CC,Su FH,Tzeng CR,Muo CH,Wang WC. Women with adenomyosis are at higher risks of endometrial and thyroid cancers: A population-based historical cohort study . PLOS ONE .2018 ;(13):e0194011-z

13. 2018 Chang TJ,Wang WC,Hsiung CA,He CT,Lin MW,Sheu WHH, Chang YC, Quertermous T, Chen YDI, Rotter JI, Chuang LM. Genetic variation of SORBS1 gene is associated with glucose homeostasis and age at onset of diabetes: A SAPPHIRe Cohort Study . Scientific Reports .2018 ;(8):10574-z

14. 2018 Wang WC,Chiu YF,Chung RH,Hwu CM,Lee IT,Lee CH, Chang YC, Hung KY, Quertermous T, Chen YDI, Hsiung CA. IGF1 gene is associated with triglyceride levels in subjects with family history of hypertension from the SAPPHIRe and TWB projects . International Journal of Medical Sciences .2018 ;(15):1035-1042

15. 2018 Kamiza AB,Hsieh LL,Tang R,Chien HT,Lai CH,Chiu LL, Lo TP, Hung KY, You JF, Wang WC, Hsiung CA, Yeh CC. Polymorphisms of DNA repair genes are associated with colorectal cancer in patients with Lynch syndrome . Molecular Genetics & Genomic Medicine .2018 ;(6):533-540

16. 2018 Kamiza AB,Wang WC,You JF,Tang R,Wang YT,Chien HT, Lai CH, Chiu LL, Lo TP, Hung KY, Hsiung CA, Yeh CC. EGFR, SMAD7, and TGFBR2 polymorphisms are associated with colorectal cancer in patients with Lynch syndrome . Anticancer Research .2018 ;(38):5983-5990

17. 2017 Seow WJ,Matsuo K,Hsiung CA,Shiraishi K,Song M,Kim HN, Wong MP, Hong YC, Hosgood HD III, Wang Z, et al.. Association between GWAS-identified lung adenocarcinoma susceptibility loci and EGFR mutations in never-smoking Asian women, and comparison with findings from Western populations . Human Molecular Genetics .2017 ;(26):454-465

18. 2017 Sheu WHH,Wang WC,Wu KD,He CT,Hwu CM,Quertermous T, Hsieh WS, Lee WJ, Ting CT, Chen YDI, Hsiung CA. CRP-level-associated polymorphism rs1205 within the CRP gene is associated with 2-hour glucose level: The SAPPHIRe study . Scientific Reports .2017 ;(7):7987-yyy

19. 2017 Wei-Chiao Chen,Wen-Chang Wang,Hsing-Fang Lu,Yukinori Okada,Wei-Pin Chang,Yii-Her Chou, Hui-Hua Chang, Jin-Ding Huang, Der-Yuan Chen, Wei-Chiao Chang. rs2841277 (PLD4) is associated with susceptibility and rs4672495 is associated with disease activity in rheumatoid arthritis . Oncotarget .2017 ;(8):64180-64190

20. 2017 Jing-Wen Shih,Wei-Fan Chiang,Alexander T.H. Wu,Ming-Heng Wu,Ling-Yu Wang,Yen-Ling Yu, Yu-Wen Hung, Wen-Chang Wang, Cheng-Ying Chu, Chiu-Lien Hung, Chun A. Changou, Yun Yen, Hsing-Jien Kung. Long noncoding RNA LncHIFCAR/MIR31HG is a HIF-1α co-activator driving oral cancer progression . Nature Communications .2017 ;(8):15874

21. 2017 Chang IS,Jiang SS,Yang JCH,Su WC,Chien LH,Hsiao CF, Lee JH, Chen CY, Chen CH, Chang GC et al.. Genetic Modifiers of Progression-Free Survival in Never-Smoking Lung Adenocarcinoma Patients Treated with First-Line Tyrosine Kinase Inhibitors . American Journal of Respiratory and Critical Care Medicine .2017 ;(195):663-673

22. 2016 Wang Z,Seow WJ,Shiraishi K,Hsiung CA,Matsuo K,Liu J, Chen K, et al.. Meta-analysis of genome-wide association studies identifies multiple lung cancer susceptibility loci in never-smoking Asian women . Human Molecular Genetics .2016 ;(25):620-629

23. 2016 Chang TJ,Wang WC,Hsiung CA,He CT,Lin MW,Sheu WHH, Chang YC, Quertermous T, Chen I, Rotter J, Chuang LM, and the SAPPHIRe Study Group. Genetic variation in the human SORBS1 gene is associated with blood pressure regulation and age at onset of hypertension: A SAPPHIRe cohort study . Medicine .2016 ;(95):e2970-z

24. 2016 Yeh CC,Wang WC,Wu CS,Sung FC,S CT,Shieh YH, Chang SN, Su FH. Association of Sjögrens Syndrome in Patients with Chronic Hepatitis Virus Infection: A Population-Based Analysis . PLOS ONE .2016 ;(11):161958-xxx

25. 2016 Kamiza AB,Su FH,Wang WC,Sung FC,Chang SN,Yeh CC. Chronic hepatitis infection is associated with extrahepatic cancer development: a nationwide population-based study in Taiwan . BMC Cancer .2016 ;(16):861

26. 2016 Kamiza AB,Hsieh LL,Tang R,Chien HT,Lai CH,Chiu LL, Lo TP, Hung KY, You JF, Wang WC, Hsiung CA, Yeh CC. TP53 Polymorphisms and Colorectal Cancer Risk in Patients with Lynch Syndrome in Taiwan: A Retrospective Cohort Study . PLOS ONE .2016 ;(11):167354

27. 2015 Machiela MJ,Hsiung CA,Shu XO,Seow WJ,Wang Z,Matsuo K, Hong YC, Seow A, Wu C, Hosgood III HD, Chen K, Wang JC, Wen W, Cawthon R, Chatterjee N, Hu. Genetic variants associated with longer telomere length are associated with increased lung cancer risk among never-smoking women in Asia: A report from the Female Lung Cancer Consortium in Asia . International Journal of Cancer .2015 ;(137):311-319

28. 2015 Wei JCC,Wong HSC,Hsu YW,Wen YF,Wang WC,Wong RH, Lu HF, Gaalen FA, Chang WC. Interaction between HLA-B60 and HLA-B27 as a Better Predictor of Ankylosing Spondylitis in a Taiwanese Population . PLOS One .2015 ;(10):137189-xxx

29. 2013 Wu X,Wang L,Ye Y,Aakre JA,Pu X,Chang GC et al.. Genome-wide association study of genetic predictors of overall survival for non-small cell lung cancer in never smokers . Cancer Research .2013 ;(73):4028-4038

30. 2013 Wu Y,Waite LL,Jackson AU,Sheu WHH,Buyske S,Absher D et al. Trans-ethnic fine-mapping of lipid loci identifies population-specific signals and allelic heterogeneity that increases the trait variance explained . PLOS Genetics .2013 ;(9):3379

31. 2012 Lan Q,Hsiung CA,Matsuo K,Hong YC,Seow A,Wang Z, et al.. Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia . Nature Genetics .2012 ;(44):1330-1335

32. 2012 Hosgood HD,Wang WC,Hong YC,Wang JC,Chen KX,Chang IS, et al.. Genetic variant in TP63 on locus 3q28 is associated with risk of lung adenocarcinoma among never-smoking females in Asia . Human Genetics .2012 ;(131):1197-1203

33. 2012 Chen CH,Su WC,Chen CY,Huang JY,Tsai FY,Wang WC, Hsiung CA, Jeng KS, Chang IS. A Bayesian measurement error model for two-channel cell-based RNAi data with replicates . Annals of Applied Statistics .2012 ;(6):356-382

34. 2011 Wang WC,Hsiung CA,Chuang LM,Wang LC,Quertermous T,Chang IS. Distribution of the number of false discoveries in large-scale family based association testing with application to the association between PTPN1 and hypertension and obesity . Human Genetics .2011 ;(129):425-432

35. 2010 Hsiung CA,Lan Q,Hong YC,Chen CJ,Hosgood HD,Chang IS, et al.. The 5p15.33 locus is associated with risk of lung adenocarcinoma in never-smoking females in Asia . PLOS Genetics .2010 ;(6)

36. 2006 Wang WC,Chang IS,Chang CH,Curb D,Ho LT,Hsiung CA. Incorporating endophenotypes into allele-sharing based linkage tests . Genetic Epidemiology .2006 ;(30):133-142


1. 2009 Wang WC,Chang IS,Chuang LM,Quertermous T,Hsiung CA. Assessing false discovery rate in large-scale family based association testing . The American Society of Human Genetics 59th annual meeting .2009

2. 2007 Wang WC,Chang IS,Chang CH,Hsiung CA. Incorporating endophenotypes into family-based allelic association studies . The American Society of Human Genetics 57th annual meeting .2007

3. 2005 Wang WC,Chang IS,Chuang YC,Hsiung CA. A flexible Monte Carlo approach to multipoint linkage analysis . 2005 Joint Statistical Meetings. Minneapolis, Minnesota. .2005

研究計畫

計畫名稱
108 結合全基因組連鎖分析與次世代定序方法尋找遺傳性大腸直腸癌致病基因(3/3)
補助單位
科技部

計畫名稱
107 紫膜光電生物晶片應用於食安快速檢測之探討
補助單位
臺北醫學大學

計畫名稱
107 結合全基因組連鎖分析與次世代定序方法尋找遺傳性大腸直腸癌致病基因(2/3)
補助單位
科技部

計畫名稱
106 結合全基因組連鎖分析與次世代定序方法尋找遺傳性大腸直腸癌致病基因(1/3)
補助單位
科技部

計畫名稱
102 全基因組連鎖分析中錯誤發現數目分布的估計
補助單位
行政院國家科學委員會

計畫名稱
102 全基因組連鎖分析中錯誤發現數目分布的估計
補助單位
科技部

計畫名稱
101 TMU101-AE1-B67
補助單位
學校