王皓青(Wang, Hao-Ching) 副教授

Email
wanghc@tmu.edu.tw
現   職
轉譯醫學博士學位學程 副教授

學經歷

學 歷

畢業學校與學位[修業時間]
臺灣大學生化科學 博士
2003/09~2008/06
中興大學生物化學 碩士
2000/09~2003/07
東海大學食品科學 學士
1995/09~2000/07

本校學術經歷

任職單位與職稱[起迄時間]
轉譯醫學博士學位學程副教授
2017/02/01~
轉譯醫學博士學位學程助理教授
2013/08/01~2017/01/31

本校兼職教學行政經歷

服務單位與職稱[起迄時間]
國際轉譯科學博士學位學程籌備處副教授
2020/05/01 ~
醫學資訊研究所副教授
2019/11/01 ~

其它經歷

任職單位與職稱[起迄時間]
中央研究院生物化學研究所博士後研究員
2009/09/01~2013/07/31

專長與研究領域

學門領域
醫學之生化及分子生物
學術專長

論文著作

清冊下載


1. 2020 Huang JY,Wang HC,Chen YC,Wang PS,Lin SJ,Chang YS, Liu KF, Lo CF. A shrimp glycosylase protein, PmENGase, interacts with WSSV envelope protein VP41B and is involved in WSSV pathogenesis . Dev Comp Immunol .2020

2. 2020 Liao YT,Lin SJ,Ko TP,Liu CY,Hsu KC,Wang HC. Structural insight into the differential interactions between the DNA mimic protein SAUGI and two gamma herpesvirus uracil-DNA glycosylases . International Journal of Biological Macromolecules .2020

3. 2020 A Review of the Functional Annotations of Important Genes in the AHPND-Causing pVA1 Plasmid. . Microorganisms .2020 ;(8):996

4. 2019 Wang HC,Chou CC,Hsu KC,Lee CH,Wang AHJ. New paradigm of functional regulation by DNA mimic proteins: Recent updates . IUBMB Life .2019 ;(71):539-548

5. 2019 Lin SJ,Chen YF,Hsu KC,Chen YL,Ko TP,Lo CF, Wang HC, Wang HC . Structural Insights to the Heterotetrameric Interaction between the Vibrio parahaemolyticus PirAvp and PirBvp Toxins and Activation of the Cry-Like Pore-Forming Domain . Toxins .2019 ;(11):233-233

6. 2019 Chang HW,Yang CH.,Luo YC,Su BG1,Cheng HY,Tung SY, Carillo KJD, Liao YT, Tzou DM, Wang HC, Chang W. Vaccinia viral A26 protein is a fusion suppressor of mature virus and triggers membrane fusion through conformational change at low pH . PLoS Pathogen .2019 ;(15):e1007826-e1007826

7. 2019 Liao YT,Lin SS,Lin SJ ,Shen BN,Cheng HP,Lin CP, Ko TP, Chen YF, Sun WT, Wang HC. Structural insights into the interaction between phytoplasmal effector causing phyllody 1 (PHYL1) and MADS transcription factor . Plant journal .2019

8. 2018 Chen CH,Changou C,Hsieh TH,Lee YC,Chu CY,Hsu KC, Wang HC, Lin YC, Lo YN, Liu YR, Liou JP, Yen Y. Dual Inhibition of PIK3C3 and FGFR as a New Therapeutic Approach to Treat Bladder Cancer . Clinical Cancer Research .2018 ;(24):1176-1189

9. 2018 Cheng CH,Shen BN,Shang QW,Liu LY,Peng KC,Chen YH, Chen FF, Hu SF, Wang YT, Wang HC, Wu HY, Lo CT, Lin SS. Gene-to-gene network analysis of the mediation of plant innate immunity by the eliciting plant response-like 1 (Epl1) elicitor of Trichoderma formosa. Mol Plant Microbe Interact . Mol Plant Microbe Interact .2018 ;(31):683-691

10. 2017 Lin SJ,Hsu KC,Wang HC. Structural Insights into the Cytotoxic Mechanism of Vibrio parahaemolyticus PirAvp and PirBvp Toxins. . Mar. Drugs .2017 ;(15):373

11. 2017 Huang MF,Lin SJ,Ko TP,Liao YT,Hsu KC,Wang HC. The monomeric form of Neisseria DNA mimic protein DMP19 prevents DNA from binding to the histone-like HU protein . PLOS ONE .2017 ;(12):e0189461

12. 2016 Wang HC,Ho CH,Chou CC,Ko TP,Huang MF,Hsu KC, Wang AHJ. Using structural-based protein engineering to modulate the differential inhibition effects of SAUGI on human and HSV uracil DNA glycosylase. . Nucleic Acids Res. .2016 ;(44):4440-4449

13. 2015 Lin SJ,Lee DY,Wang HC,Kang ST,Hwang PP,Kou GH, Huang MF, Chang GD, Lo CF*. White Spot Syndrome Virus Protein Kinase 1 (PK1) Defeats the Host Cell's Iron Withholding Defense Mechanism by Interacting with Host Ferritin. . J Virol. .2015 ;(89):1083-1093

14. 2015 Lee CT,Chen IT,Yang YT,Ko TP,Huang YT,Huang JY,Huang MF,Lin SJ,Chen CY,Lin SS,Lightner DV,Wang HC,Wang AHJ,Wang HC,Hor LI,LO CF. The opportunistic marine pathogen Vibrio parahaemolyticus becomes virulent by acquiring a plasmid that expresses a deadly toxin. . Proc. Natl. Acad. Sci. USA .2015 ;(112):10798-10803

15. 2015 Liu BH,Lin YC,Ho C,Yang CC,Chang YT,Chang JF, Li CY, Cheng CS, Huang JY, Lee YF, Hsu MH, Lin FC, Wang HC, Lo CF, Yang SY, Wang HC. Novel Detection Platform for Shrimp White Spot Syndrome Virus Using an ICP11-Dependent Immunomagnetic Reduction (IMR) Assay . PLoS One .2015 ;(10):138207

16. 2014 Wang HC,Hsu KC,Yang JM,Wu ML,Ko TP,Lin SR, Wang AHJ. Staphylococcus aureus protein SAUGI acts as a uracil-DNA glycosylase inhibitor . Nucleic Acids Res .2014 ;(42):1354-1364

17. 2014 Wang HC,HO CH,Hsu KC,Yang JM,Wang AHJ. DNA Mimic Proteins: Functions, Structures, and Bioinformatic Analysis . Biochemistry .2014 ;(53):2865-2874

18. 2014 Ho CH,Wang HC,KO TP,Chang YC,Wang AHJ. The T4 Phage DNA Mimic Protein Arn Inhibits the DNA Binding Activity of the Bacterial Histone-like Protein H-NS . J Biol Chem .2014 ;(289):27046-27054

19. 2014 Lee CC,Maestre-Reyna M,Hsu KC,Wang HC,Liu CI,Jeng WY, Lin LL, Wood R, Chou CC, Yang JM, Wang AHJ. Crowning Proteins: Modulating the Protein Surface Properties using Crown Ethers. . Angew Chem Int Ed Engl .2014 ;(53):13054-13058

20. 2013 Wang HC,Wu ML,Ko TP,Wang AHJ. Neisseria conserved hypothetical protein DMP12 is a DNA mimic that binds to histone-like HU protein. . Nucleic Acids Res .2013 ;(41):5127-5138

21. 2012 Wang HC,Ko TP,Wu ML,Ku S,Wu HJ,Wang AHJ. Neisseria conserved protein DMP19 is a DNA mimic protein that prevents DNA binding to a hypothetical nitrogen-response transcription factor. . Nucleic Acids Res .2012 ;(40):5718-5730

22. 2012 Huang JY,Liu WJ,Wang KC HC,Lee DY,Leu JH,Wang HC, Tsai MH, Chen IT, Kou GH, Chang GD*, Lo CF*. Penaeus monodon thioredoxin restores the DNA binding activity of oxidized WSSV IE1. . Antioxidants & Redox Signaling .2012 ;(17):914-926

23. 2012 Chaikeeratisak V,Somboonwiwat K,Wang HC,Lo CF,Tassanakajon A. Proteomic analysis of differentially expressed proteins in the lymphoid organ of Vibrio harveyi-infected Penaeus monodon. . Mol Biol Rep .2012 ;(39):6367-6377

24. 2011 Tseng CW,Ko TP,Guo RT,Huang JW,Wang HC,Huang CH, Cheng YS, Wang AHJ, Liu JR. Substrate binding of a GH5 endoglucanase from the ruminal fungus Piromyces rhizinflata. . Acta Crystallogr Sect F .2011 ;(67):1189-1194

25. 2011 Lin YR,Hung HC,Leu JH,Wang HC,Kou GH,Lo CF. The role of ALDH and HSP 70 in the suppression of white spot syndrome virus replication at high temperature. . J Virol. .2011 ;(85):3517-3525

26. 2010 Somboonwiwat K,Chaikeeratisak V,Wang HC,Lo CF,Tassanakajon A. Proteomic analysis of differentially expressed proteins in Penaeus monodon hemocytes after Vibrio harveyi infection. . Proteome Sci .2010 ;(8):39

27. 2008 Wang HC,Wang KC HC,Ko TP,Leu JH,Huang WP,Lo CF, Wang AHJ. White spot syndrome virus protein ICP11: A histone-binding DNA mimic that disrupts nucleosome assembly. . Proc Natl Acad Sci U S A. .2008 ;(105):20758-20763

28. 2008 Liu WJ,Chang YS,Wang HC,Leu JH,Kou GH,Lo CF. Transactivation, dimerization, and DNA-binding activity of white spot syndrome virus immediate-early protein IE1. . J Virol .2008 ;(82):11362-11373

29. 2008 Leu JH,Wang HC,Kou GH,Lo CF. Penaeus monodon caspase is targeted by a white spot syndrome virus anti-apoptosis protein. . Dev Comp Immunol .2008 ;(32):476-486

30. 2007 Rattanarojpong T,Wang HC,Lo CF,Flegel TW. Analysis of differently expressed proteins and transcripts in gills of Penaeus vannamei after yellow head virus infection. . Proteomics .2007 ;(7):3809-3814

31. 2007 Wang HC,Wang KC HC,Leu JH,Kou GH,Wang AHJ,Lo CF. Protein expression profiling of the shrimp cellular response to white spot syndrome virus infection. . Dev Comp Immunol .2007 ;(31):672-686

32. 2007 Wang KC HC,Wang HC,Kou GH,Lo CF,Huang WP. Identification of icp11, the most highly expressed gene of shrimp white spot syndrome virus (WSSV). . Dis Aquat Organ. .2007 ;(74):179-189


1. 2018 Crystal Structure of Vaccinia Viral A26 Protein . 2018 XXII INTERNATIONAL POXVIRUS, ASFARVIRUS AND IRIDOVIRUS CONFERENCE .2018

2. 2016 Wang HC. Potential application of the Staphylococcus aureus DNA mimic protein SAUGI in combating human viral disease . 2016 Taiwan-Japan joint Symposium on Protein Crystallography .2016

3. 2015 Wang, HC,Ho, CH,Chou, CC,Ko, TP,Huang, MF,Wang, AHJ. Potential application of the Staphylococcus Aureus DNA mimic protein SAUGI in combating human viral disease . 2015 International Congress on Chemical, Biological and Environmental Sciences (ICCBES) .2015

4. 2012 Wang HC. Structural and functional analysis of DNA mimic proteins. . .2012

5. 2012 Ho CH,Wang HC,Wang AHJ. Characterization of the potential DNA mimic protein from virus. . .2012

6. 2012 Wang HC,Ko TP,Wu ML,Ku S,Wu HJ,Wang AHJ. Neisseria conserved protein DMP19 is a DNA mimic protein that prevents DNA binding to a hypothetical transcription factor. . .2012

7. 2007 Chiang YC,Ho CH,Wang HC,Lo CF. Proteomic analysis of differentially expressed proteins in Litopenaeus vannamei hepatopancreas cells after white spot syndrome virus infection. . .2007

8. 2007 Ho CH,Wang HC,Lo CF. A functional study of the highly expressed gene wssv019 (VP35) of white spot syndrome virus. . .2007

9. 2007 Wang HC,Wang KC HC,Ko TP,Leu JH,Lo CF,Wang AHJ. Protein expression profiling of the shrimp cellular response to white spot syndrome virus infection. . .2007

10. 2005 Wang HC,Wang KC HC,Peng SE,Chiou SH,Wang AHJ,Lo CF. Proteomic analysis of differentially expressed proteins in Litopenaeus vannamei stomach cells after white spot syndrome virus infection. . .2005

11. 2005 Wang HC,Wang KC HC,Peng SE,Lo CF,Chiou SH. Modulation of GAPDH and fructose-biphosphate aldolase expression in shrimps after white spot syndrome virus (WSSV) infection. . .2005

12. 2005 Wang HC,Wang KC HC,Peng SE,Lo CF,Chiou SH. Proteomic analysis of differentially expressed proteins in Litopenaeus vannamei stomach cells after white spot syndrome virus infection. . .2005

研究計畫

計畫名稱
109 利用結構生物學與蛋白質體學探討植物菌質體 PHYL1 交互作用蛋白質
補助單位
科技部

計畫名稱
109 探索蝦急性肝胰腺壞死病毒素 PirAvp 與 PirBvp 之活化機制與中和策略(1/3)
補助單位
科技部

計畫名稱
108 轉譯醫學博士學位學程廖怡婷博士候選人申請本部補助臺德 (MOST -DAAD)博士候選人赴德研修計畫 (三明治計畫)109年春季班案
補助單位
科技部

計畫名稱
108 利用系統生物學探討蝦類急性肝胰臟壞死病(AHPND)之致病機轉(3/3)
補助單位
科技部

計畫名稱
108 蝦急性肝胰腺壞死病毒素 PirAvp 與 PirBvp 之轉錄調節機制探討
補助單位
臺北醫學大學

計畫名稱
107 利用結構生物學與蛋白質體學探討光桿菌 PirApl 與 PirApl殺蟲毒素之細胞毒殺機制
補助單位
科技部

計畫名稱
107 受石斑虹彩病毒(grouper iridovirus)誘導表現之點帶石斑L型胺基酸氧化酶之免疫功能鑑定
補助單位
臺北醫學大學

計畫名稱
106 利用結構生物學之方法探索 DNA 擬態蛋白質 SAUGI 於病毒性疾病以及耐甲氧西林金黄色葡萄球菌研究之應用
補助單位
科技部

計畫名稱
105 利用結構生物學探討 DNA 擬態蛋白質與其目標 DNA 結合蛋白質的交互作用(3/3)
補助單位
科技部

計畫名稱
105 利用結構生物學探討 DNA 擬態蛋白質與其目標 DNA 結合蛋白質的交互作用(3/3)
補助單位

計畫名稱
104 利用結構生物學探討 DNA 擬態蛋白質與其目標 DNA 結合蛋白質的交互作用(2/3)
補助單位
科技部

計畫名稱
104 利用結構生物學探討 DNA 擬態蛋白質與其目標 DNA 結合蛋白質的交互作用(2/3)
補助單位
科技部

計畫名稱
103 利用結構生物學探討 DNA 擬態蛋白質與其目標 DNA 結合蛋白質的交互作用(1/3)
補助單位
科技部

計畫名稱
103 利用結構生物學探討 DNA 擬態蛋白質與其目標 DNA 結合蛋白質的交互作用(1/3)
補助單位
科技部

計畫名稱
102 金黃色葡萄球菌 DNA 擬態蛋白質 SAUGI 於人類病毒疾病上之潛在應用
補助單位
行政院國家科學委員會

計畫名稱
102 金黃色葡萄球菌 DNA 擬態蛋白質 SAUGI 於人類病毒疾病上之潛在應用
補助單位
科技部

計畫名稱
102 TMU102-AE1-B12
補助單位
學校