宋賢穎(Sung, Shian-Ying) 副教授

Email
ssung@tmu.edu.tw
現   職
人體研究處 副人研長
國際轉譯科學博士學位學程 副教授

學經歷

學 歷

畢業學校與學位[修業時間]
維吉尼亞邦聯大學醫學院微生物及免疫 博士
1994/08~2000/08
中山醫學院醫事技術學系 學士
1987/09~1991/07

本校學術經歷

任職單位與職稱[起迄時間]
國際轉譯科學博士學位學程副教授
2020/08/01~
國際轉譯科學博士學位學程籌備處副教授
2020/05/01~2020/07/31
轉譯醫學博士學位學程副教授
2013/08/01~2020/04/30

本校兼職教學行政經歷

服務單位與職稱[起迄時間]
轉譯醫學博士學位學程副教授
2020/07/01 ~
醫學資訊研究所副教授
2019/11/01 ~
人體研究處副人研長
2019/08/01 ~
聯合臨床試驗中心代理主任
2018/08/01 ~ 2019/07/31
聯合臨床試驗中心副主任
2015/10/01 ~ 2019/07/31

其它經歷

任職單位與職稱[起迄時間]
中國醫藥大學助理教授
2007/08/01~2013/07/31

專長與研究領域

學門領域
醫學之生化及分子生物
泌尿科
轉譯醫學專案研究計畫
血液科腫瘤科風濕免疫及感染
學術專長
3D Co-culture
Chemotaxis cell migration
xenograph animal model
introtibia injection
intracardiac injection
Western Blotting
Immunoprecipitation
Yeast 2 Hybrid study

論文著作

清冊下載


1. 2020 Tran HM,Wu KS,Sung SY,Changou CA,Hsieh TH,Liu YR, Liu YL, Tsai ML, Lee HL, Hsieh KLC, Huang WC, Liang ML, Chen HH, Lee YY, Lin SC, Ho DMT, Chang FC, Chao ME, Chen W, Chu SS, Yu ALT, Yen Y, Chang CC, Wong TT. Upregulation of Protein Synthesis and Proteasome Degradation Confers Sensitivity to Proteasome Inhibitor Bortezomib in Myc-Atypical Teratoid/Rhabdoid Tumors . Cancers .2020 ;(12):752

2. 2020 Noriaki Maeshige,Koichi Kitagawa,Saya Yamasaki,Aya Ishii,Toshiro Shirakawa,Yong-Ming Yang, Shian-Ying Sung, Kuan-Chou Chen, Zhi-Ming Yuan, Katsumi Shigemura, Masato Fujisawa. Can ultrasound irradiation be a therapeutic option for prostate cancer? . Prostate .2020 ;(80):986-992

3. 2020 Aya Ishii,Katsumi Shigemura,Koichi Kitagawa,Shian-Ying Sung,Kuan-Chou Chen,Yi-Te Chiang, Ming-Che Liu, Masato Fujisawa. Anti-tumor Effect of Hedgehog Signaling Inhibitor, Vismodegib, on Castration-resistant Prostate Cancer . Anticancer Res. .2020 ;(40):5017-5114

4. 2020 ,Trang Thi Huynh Le. Alpha-1 blocker use increased risk of subsequent renal cell carcinoma: A nationwide population-based study in Taiwan . PLoS One .2020 ;(15):e0242429

5. 2020 Chen BW*,He YC*,Sung SY,Le TTH,Hsieh CL,Chen JY, Wei ZH, Yao DJ. Synthesis and characterization of magnetic nanoparticles coated with polystyrene sulfonic acid for biomedical applications . Sci Technol Adv Mater .2020 ;(21):471-481

6. 2020 Chiag YT,Shigemura K,Nishimoto K,Yamada N,Kitagawa K,Sung SY, Chen KC, Fujisawa M. Urinary tract infection pathogens and antimicrobial susceptibilities in Kobe, Japan and Taipei, Taiwan: an international analysis . J. Int. Med. Res. .2020 ;(48):300060519867826

7. 2020 Wu KS,Ho DMT,Jou ST,Yu AL,Tran HM,Liang ML, Chen HH, Lee YY, Chen YW, Lin SC, Chang FC, Tsai ML, Liu YL, Lee HL, Hsieh KLC, Huang WC, Sung SY, Chang CC, Cahngou CA, Liang KH, Hsieh TH, Liu YR, Chao ME, Chen W, Chu SS, Cho EC, and Wong TT.. Molecular-Clinical Correlation in Pediatric Medulloblastoma: A Cohort Series Study of 52 Cases in Taiwan . Cancers .2020 ;(12):653

8. 2019 Shigemura K.,Kitagawa K.,Chen KC,Sung SY,Fujisawa M.. Effect of Preoperative Dutasteride on Holmium Laser Enucleation of the Prostate . Urologia Internationalis .2019 ;(4):1-5

9. 2019 KDM8/JMJD5 as a dual coactivator of AR and PKM2 integrates AR/EZH2 network and tumor metabolism in CRPC . Oncogene .2019 ;(38)

10. 2019 Chu GCY,Chuung LWK,Gururajan M,Hsieh CL,Josson S,Nandana S, Sung SY, Wang R, Wu JB, Zhau HE. Regulatory signaling network in the tumor microenvironment of prostate cancer bone and visceral organ metastases and the development of novel therapeutics. . Asian J. of Urology .2019 ;(6):65-81

11. 2019 Kitagawa K.,Shigemura K.,Huang CC,Chiang YT, Liu MC, Huang TW, Yamamichi F, Shirakawa T, Fujisawa M. Possible correlation of sonic hedgehog signaling with epithelial-mesenchymal transition in muscle-invasive bladder cancer progression. . J. Cancer Research Clin. Oncol. .2019 ;(145):2261-2271

12. 2019 Chiang YT,Shigemura K,Nishimoto K,Yamada N,Kitagawa K,Sung SY, Chen KC, Fujisawa M. Urinary tract infection pathogens and antimicrobial susceptibilities in Kobe, Japan and Taipei, Taiwan: an international analysis. . J. Int. Med. Res. .2019 ;(Epub ahead of Print)

13. 2019 Hsieh CL,Huang HS,Chen KC,Saka T,Chiang CY,Chung LWK, Sung SY. A novel salicylanilide derivative induces autophagy cell death in castration-resistant prostate cancer via ER stress-activated PERK signaling pathway . Molecular Cancer Therapeutics .2019 ;(19):101-111

14. 2019 Shigemura K,Kitagawa K,Chen KC,Sung SY,Fujisawa M. Effect of Preoperative Dutasteride on Holmium Laser Enucleation of the Prostate. . Urol. Int. .2019 ;(Epub ahdead of Print)

15. 2019 Shigemura S.,Sung SY,Chen KC,Fujisawa M.. Comment for "nomogram establishment for surgery-related complications in partial nephrectomy". . Annals of Translational Medicine .2019 ;(7):s120

16. 2018 Lin YC,Lin YC,Peng CC,Chen KC,Chen HH,Fang TC, Sung SY*, Wu MS*. Effects of Cholesterol Levels on Mortality in Patients with Long-Term Peritoneal Dialysis Based on Residual Renal Function . Nutrients .2018 ;(10):300-300

17. 2018 Wang HJ,Pochampalli M,Wang LY,Zou JX,Li PS,Hsu SC, Wang BJ, Huang SH, Yang P, Yang JC, Chu CY, Hsieh CL, Sung SY, LI CF, Tepper CG, Ann DK, Gao AC, Evans CP, Izumiya Y, Chuu CP, Wang WC, Chen HW, Kung HJ. KDM8/JMJD5 as a dual coactivator of AR and PKM2 integrates AR/EZH2 network and tumor metabolism in CRPC. . Oncogene .2018 ;(38):17-32

18. 2017 Hsieh CL,Liu CM,Chen HA,Yang ST,Shigemura K,Kitagawa K, Yamamichi F, Fujisawa M, Liu YR, Lee WH, Chen KC, Shen CN, LIN CC, Chung L, Sung SY. Reactive oxygen species–mediated switching expression of MMP-3 in stromal fbroblasts and cancer cells during prostate cancer progression . Scientific Reports .2017 ;(7):9065-9078

19. 2016 Sung SY,Chang JL,Chen KC,Yeh SD,Liu YR,Su YH, Hsueh CY, Chung LWK, Hsieh CL. Co-targeting prostate cancer epithelium and bone stroma by human osteonectin-promoter-mediated suicide gene therapy effectively inhibits androgen-independent prostate cancer growth . PLOS ONE .2016 ;(11):e01533

20. 2016 Chen HA,Kuo TC,Tseng CF,Ma JT,Yang ST,Sung SY, Su JL. ANGPTL1 Antagonizes MET Receptor Activity to Repress Sorafenib Resistance and Cancer Stemness in Hepatocellular Carcinoma Cells. . Hepatology .2016 ;(64):1637-1651

21. 2016 Liu CM,Hsieh CL,Shen CN,Lin CC,Shigemura K,Sung SY. Exoxomes from the tumor microenvironment as reciprocal regulators that enhance prostate cancer progression . Internation Journal of Urology .2016 ;(23):734-744

22. 2015 Su CM,Wang MY,Hong CC,Chen HA,Sun YH,Wu CH, Huang MT, Chang YW, Jiang SS, Sung SY, Chang JY, Chen LT, Chen PS, Su JL. miR-520h is crucial for DAPK2 regulation and breast cancer progression . Oncogene .2015

23. 2015 Kuan-Chou Chen,Shian-Ying Sung,Yi-Ting Lin,Chiu-Lan Hsieh,Kun-Hung Shen,Chiung-Chi Peng, Rovert Y. Peng. Benign prostate hyperplasia complicated with T1DM can be alleviated by treadmill exercise - evidences revealed by the rat model . BMC Urology .2015 ;(15):113-128

24. 2014 Josson S,Gururajan M,Sung SY,Hu P,Shao C,Zhau HE, Liu C, Lichterman J, Duan P, Li Q, A Rogatko, Posadas EM, Haga CL, Chung LWK. Stromal fibroblast-derived miR-409 promotes epithelial-to-mesenchymal transition and prostate tumorigenesis . Oncogen .2014 ;(34):2690-2699

25. 2014 Lin CY,Chen HJ,Huang CC,Lai LC,Lu TP,Tseng GC, Kuo TT, Kuok QY, Hsu JL, Sung SY, Hung MC, Sher YP. ADAM9 promotes lung cancer metastases to brain by aplasminogen activator-based pathway . Cancer Research .2014

26. 2014 Sung SY,Wu IH,Chuan PC,Petros J,Wu CC,Zheng HC, Chung LWK, Hsieh CL. Targeting L1 cell adhesion molecule expression using liposome-encapsulated siRNA suppresses prostate cancer bone metastasis and growth . Oncotarget .2014 ;(5):9911-9929

27. 2013 Sung SY,Liao CH,Wu Hp,Hsiao WC,Wu IH,Yu J, Lin SH, Hsieh CL. Loss of Let-7 microRNA upregulates IL-6 in bone marrow-derived mesenchymal stem cells triggering a reactive stromal response to prostate cancer . PLoS One .2013 ;(8):e71637

28. 2013 Che-Ming Liu,Chia-Ling Hsieh,Yun-Chi He,Sen-Jei Lo,Ji-An Liang,Teng-Fu Hsieh, Sajni Josson, Leland Chung, Mien-Chie Hung, Shian-Ying Sung. In vivo targeting of ADAM9 gene expression using lentivirus-delivered shRNA suppresses prostate cancer growth by regulating REG4 dependent cell cycle progression . PLoS One .2013 ;(8):e53795-e53795

29. 2012 C. C. Pen,C. M. Liu,C. C. Lin,C. C. Lin,T. F. Hsieh,S. Josson, Y. C. He, LWK Chung, K. Lin, SY Sung. Combined dynamic alterations in urinary VEGF levels and tissue ADAM9 expression as markers for lethal phenotypic progression of prostate cancer . Chinese J. Physiology .2012 ;(55):390-397

30. 2012 Lee GH,Sung SY,Chang WN,Kao TT,Du HC,Hsiao TH, Safo MK, Fu TF. Zebrafish larvae exposed to ginkgotoxin exhibit seizure-like behavior that is relieved by pyridoxal-5'-phosphate, GABA and anti-epileptic drugs . Disease Model and Mechanism .2012 ;(5):785-795

31. 2012 Hsiao WC,Sung SY,Liao CH,Wu HC,Hsieh CL. Vitamin D3-inducible mesenchymal stem cell-based delivery of conditionally replicating adenoviruses effectively targets renal cell carcinoma and inhibits tumor growth . Molecular Pharmarceutics .2012 ;(9):1396-1408

32. 2011 Josson S,Anderson CS,Sung SY,Johnstone PA,Kubo H,Hsieh CL, Arnold R, Gururajan M, Yates C, Chung LWK. Inhibition of ADAM9 expression induces epithelial phenotypic alterations and sensitizes human prostate cancer cells to radiation and chemotherapy . Prostate .2011 ;(71):232-240

33. 2010 Hung SC,Wu IH,Hsue SS,Liao CH,Wang HC,Chuang PH, Sung SY, Hsieh CL. Targeting L1 cell adhesion molecule using lentivirus-mediated short hairpin RNA interference reverses aggressiveness of oral squamous cell carcinoma . Molecular Pharmaceutics .2010 ;(6):2312-2323

34. 2010 Johnson NA,Chen BH,Sung SY,Liao CH,Hsiao WC,CHung LWK, Hsieh CL. A novel targeting modality for renal cell carcinoma: human osteocalcin promoter-mediated gene therapy synergistically induced by vitamin C and vitamin D. . J. Gene Med. .2010 ;(12):892-903

35. 2010 Josson S,Sharp S,Sung SY,Johnstone PAS,Aneja R,Wang R, Gururajan M, Turner T, Chung LWK, Yates C. Tumor-stromal interactions influence radiation sensitivity in epithelial-versus mesenchymal-like prostate cancer cells. . Journal of Oncology .2010 ;(2010):1-10

36. 2010 Sung SY. ADAM9 (ADAM metallopeptidase domain 9 (meltrin gamma)) . Atlas of Genetics and Cytogenetics in Oncology and Haematology .2010 ;(14):270-274

37. 2008 Sung SY,Hsieh CL,Law A,Zhau HE,Pathak S,Multani AS, Lim S, Coleman IM, Wu LC, Figg WD, Dahut WL, Nelson P, Lee JK, Amin MB, Lyles R, etc.. Coevolution of prostate cancer and bone stroma in three-dimensional coculture: implications for cancer growth and metastasis . Cancer Research .2008 ;(68):9996-10003

38. 2008 Josson S,Sung SY,Lao K,Chung LWK,Johnstone PA. Radiation modulation of microRNA in prostate cancer cell lines . Prostate .2008 ;(68):1599-1606

39. 2007 Sung SY,Hsieh CL,Wu D,Chung LWK,Johnstone PA. Tumor Microenvironment Promotes Cancer Progression, Metastasis, and Therapeutic Resistance. . Curr Probl Cancer .2007 ;(31):36-100

40. 2007 Shigemura K,Sung SY,Kubo H,Arnold RS,Fujisawa M,Gotoh A, Zhau HE, Chung LWK. Reactive oxygen species mediate androgen receptor- and serum starvation-elicited downstream signaling of ADAM9 expression in human prostate cancer cells. . Prostate .2007 ;(67):722-731

41. 2007 Chung LWK,Huang WC,Sung SY,Wu D,Odero-Marah V,Zhau HE. Cancer-host interactions: A paradigm shift brings new understanding and new opportunities. . Contemporary Cancer Research .2007 ;(2007):73-86

42. 2006 Sung SY,Kubo H,Shigemura K,Arnold RS,Logani S,Wang R, KonakaH, Nakagawa M, Mousses S, Amin M, Anderson C, Johnstone C, Johnstone P, Petros PA, etc. Oxidative stress induces ADAM9 protein expression in human prostate cancerl cells. . Cancer Reserach .2006 ;(66):9519-9526


1. 2018 Hsieh CL,Sung SY. Novel ADAM9 variant induces prostate cancer metastasis . Cancer Research .2018 ;(78):2130

2. 2017 Hsieh CL,Chen KC,Sung SY. CCRL2 regulates prostate cancer organ specific metastasis through the interaction with CCR5 . The Journal of Urology .2017 ;(197):e596

3. 2017 Liu CM,Hsieh CL,Sung SY. ADAM9-plectin interaction involved in prostate cancer malignancy progression . Cancer Research .2017 ;(77):912

4. 2013 Hsieh CL,Liu CM,He YC,Sung SY. In vivo targeting of ADAM9 gene expression using shRNA suppresses prostate cancer growth by regulating REG4 dependent cell cycle progression . Journal of Urology .2013 ;(189):322-322

5. 2013 Sung SY,Liao CH,Hsiao WC,Lin SH,Hsieh CL. Loss of Let-7 microRNA upregulates IL-6 in mesenchymal stem cells and triggers a reactive stromal responses to prostate cancer . Journal of Urology .2013 ;(189):212-212


1. 2019 Hsiao WC,Sung SY,Chung LWK,Hsieh CL. Osteonectin Promoter-mediated suicide gene therapy of prostate cancer . Suicide Gene Therapy .2019 ;(1895):27-42

2. 2019 Hsiao WC,Sung SY,Chung LWK,Hsieh CL. Osteonectin promoter-mediated suicide gene therapy of prostate cancer. Chapter 3, Suicide Gene Therapy: Methods and Protocols . Methods in Molecular Biology .2019 ;(1895):27-42

研究計畫

計畫名稱
106 分析ADAM9作為攝護腺癌惡化的新穎生物標記之角色
補助單位
科技部

計畫名稱
105 ADAM9 調節 integrin b4 之轉換率以促使前列腺癌細胞移動及浸潤之研究(3/3)
補助單位
科技部

計畫名稱
105 ADAM9 調節 integrin b4 之轉換率以促使前列腺癌細胞移動及浸潤之研究(3/3)
補助單位
科技部

計畫名稱
104 ADAM9 調節 integrin b4 之轉換率以促使前列腺癌細胞移動及浸潤之研究(2/3)
補助單位
科技部

計畫名稱
104 ADAM9 調節 integrin b4 之轉換率以促使前列腺癌細胞移動及浸潤之研究(2/3)
補助單位
科技部

計畫名稱
103 ADAM9 調節 INTEGRIN B4 之轉換率以促使前列腺癌細胞移動及浸潤之研究(1/3)
補助單位
科技部

計畫名稱
103 ADAM9 調節 integrin b4 之轉換率以促使前列腺癌細胞移動及浸潤之研究(1/3)
補助單位
科技部

計畫名稱
102 研究ADAM9與 hemidesmosome 分子之相互作用在癌症轉移中的分子機轉及未來治療之方向
補助單位
行政院國家科學委員會

計畫名稱
102 研究ADAM9與HEMIDESMOSOME分子之相互作用在癌症轉移中的分子機轉及未來治療之方向
補助單位
科技部

計畫名稱
102 前列腺骨器官轉移之專一性是由多種趨化因子共同作用而形成之結果
補助單位
科技部

計畫名稱
102 TMU102-AE1-B01
補助單位
學校

計畫名稱
101 前列腺骨器官轉移之專一性是由多種趨化因子共同作用而形成之結果(3/3)
補助單位
行政院國家科學委員會