陳美全(Chen, Mei-Chuan) 副教授

Email
mcchen1250@tmu.edu.tw
現   職
中草藥臨床藥物研發博士學位學程 副教授

學經歷

學 歷

畢業學校與學位[修業時間]
台灣大學藥理學研究所 博士
2005/09~2012/01
臺北醫學大學藥學系 學士
1999/09~2003/06

本校學術經歷

任職單位與職稱[起迄時間]
中草藥臨床藥物研發博士學位學程副教授
2018/02/01~
中草藥臨床藥物研發博士學位學程助理教授
2014/05/01~2018/01/31

本校兼職教學行政經歷

服務單位與職稱[起迄時間]
生技醫療產業研發博士學位學程副教授
2020/01/01 ~
藥物科學學科副教授
2019/11/01 ~
臨床藥物基因體學暨蛋白質體學碩助理教授
2015/08/01 ~
生藥學研究所
2014/08/01 ~

其它經歷

任職單位與職稱[起迄時間]
臺北醫學大學博士後研究
2013/08~2014/04
臺灣大學博士後研究
2012/02~2013/07

專長與研究領域

學門領域
訊號傳遞 (cell signaling)
癌症生物學 (cancer biology)
藥理機轉探討 (Pharmacological mechanism)
學術專長

論文著作

清冊下載


1. 2020 Nguyen NL, Vo TH,Lin YC, Liaw CC, Lin ZH, Chen MC, Kuo YH. Bioassay-Guided Isolation and HPLC Quantification of Antiproliferative Metabolites from Stahlianthus thorelii . Molecules .2020 ;(25):551-564

2. 2020 Lin YC,Chen MC,Hsieh TH, Liou JP,Chen CH. CK1δ as a potential therapeutic target to treat bladder cancer. . Aging .2020 ;(12):5764-5780

3. 2020 Ojha R,Nepali K ,Chen CH,Chuang KH,,Wu TY,Lin TE,Hsu KC, Chao MW, Lai MJ, Lin MH, Huang HL, Chang CD, Pan SL, Chen MC, Liou JP.. Isoindoline scaffold-based dual inhibitors of HDAC6 and HSP90 suppressing the growth of lung cancer in vitro and in vivo. . Eur J Med Chem. .2020 ;(190):112086

4. 2019 Nepali K,Lin MH,Chao MW,Peng SJ,Hsu KC, Eight Lin T, Chen MC, Lai MJ, Pan SL, Liou JP. Amide-tethered quinoline-resorcinol conjugates as a new class of HSP90 inhibitors suppressing the growth of prostate cancer cells. . Bioorg Chem. .2019 ;(91):103119-103131

5. 2019 Chen MC,Lin YC,Liao YH,Liou JP,Chen CH. MPT0G612, a Novel HDAC6 Inhibitor, Induces Apoptosis and Suppresses IFN-γ-Induced Programmed Death-Ligand 1 in Human Colorectal Carcinoma Cells. . Cancers .2019 ;(11):1617-1632

6. 2019 Mehndiratta S,Lin MH,Wu YW,Chen CH,Wu TY,Chuang KH, Chao MW, Chen YY, Pan SL, Chen MC, Liou JP. N-alkyl-hydroxybenzoyl anilide hydroxamates as dual inhibitors of HDAC and HSP90, downregulating IFN-γ induced PD-L1 expression. . Eur J Med Chem. .2019 ;(185):111725-111739

7. 2019 Wang SW,Lin MH,Hsu FC,Chen MC,Liou JP,Liu YT, Chen SS, Lee HY. Synthesis and biological evaluation of 2-quinolineacrylamides. . Bioorg Med Chem. .2019 ;(28):115250-115259

8. 2018 Lai MJ,Ojha R,Lin MH,Liu YM, Lee HY,Lin TE, Hsu KC, Chang CY, Chen MC, Nepali K, Chang JY, Liou JP. 1-Arylsulfonyl indoline-benzamides as a new antitubulin agents, with inhibition of histone deacetylase. . Eur J Med Chem. .2018 ;(162):612-630

9. 2018 Mei-Chuan Chen ,Guei-Jane Wang ,Yueh-Hsiung Kuo ,Yin-Ru Chiang,Ting-Yu Cho, Yu-Ming Ju, Tzong-Huei Lee . Isoprenyl phenolic ethers from the termite nest-derived medicinal fungus Xylaria fimbriata . Journal of Food and Drug Analysis .2018 ;(27):111-117

10. 2017 Tung-Yun Wu,Ting-Yu Cho,Chung-Kung Lu,Jing-Ping Liou,Mei-Chuan Chen. Identification of 7-(4-Cyanophenyl)indoline-1-benzenesulfonamide as a mitotic inhibitor to induce apoptotic cell death and inhibit autophagy in human colorectal cancer cells. . Sci Rep. .2017 ;(7):1-12

11. 2017 Chen Mei Chuan ,Cho Ting Yu ,Kuo Yueh Hsiung ,Lee Tzong Huei . Meroterpenoids from a Medicinal Fungus Antrodia cinnamomea . Journal of Natural Products .2017 ;(80):2439-2446

12. 2017 Kunal Nepali,Hsueh-Yun Lee,Mei-Jung Lai,Ritu Ojha,Tung-Yun Wu,Gu-Xian Wu, Mei-Chuan Chen, Jing-Ping Liou. Ring-opened tetrahydro-g-carbolines display cytotoxicity and selectivity with histone deacetylase isoforms . European Journal of Medicinal Chemistry .2017 ;(15):115-127

13. 2017 Ming-Horng Tsai,Ju fang Liu,Yao-Chang Chiang,Chu-Sung Hu,Lee-Fen Hsu,Yu-Ching Lin, Zih-Chan Lin, Hui-Chun Lee, Mei-Chuan Chen, Chieh-Liang Huang, and Chiang-Wen Lee.. Artocarpin, an isoprenyl flavonoid, induces p53-dependent or independent apoptosis via ROS-mediated MAPKs and Akt activation in non-small cell lung cancer cells. . Oncotarget .2017

14. 2017 Mei-Chuan Chen,Yi-Chiu Kuo,Chia-Ming Hsu,Yi-Lin Chen,Chien-Chang Shen,Che-Ming Teng, Shiow-Lin Pan. The apoptotic mechanisms of MT-6, a mitotic arrest inducer, in human ovarian cancer cells . ScientificReports .2017 ;(7):46149-46149

15. 2016 Cho TY,Wang GJ,Ju YM,Chen MC,Lee TH. Chemical Constituents from Termite-associated Xylaria acuminatilongissima YMJ623 . Journal of the Chinese Chemical Society .2016 ;(63):404-409

16. 2016 Hung HL,Chao MW,Chen CC,Cheng CC,Chen MC,Lin CF. LTP-1, a novel antimitotic agent and Stat3 inhibitor, inhibits human pancreatic carcinomas in vitro and in vivo. . Scientific Reports .2016 ;(6)

17. 2016 Huang HL,Chao MW,Li YC,Chang LH,Chen CH,Chen MC. MPT0G066, a novel anti-mitotic drug, induces JNK-independent mitotic arrest, JNK-mediated apoptosis, and potentiates antineoplastic effect of cisplatin in ovarian cancer . Scientific Reports .2016 ;(6)

18. 2016 Chen Mei-Chuan ,Huang Hui-Hsuan ,Lai Chin-Yu ,Lin Yi-Jyun ,Liou Jing-Ping . Novel histone deacetylase inhibitor MPT0G009 induces cell apoptosis and synergistic anticancer activity with tumor necrosis factor-related apoptosis-inducing ligand against human hepatocellular carcinoma . Oncotarget .2016 ;(7):402-17

19. 2015 Chen MC,Zhou B,Zhang K,Yuan YC,Un F,Hu S, Chou CM, Chen CH, Wu J, Wang Y, Liu X, Smith L, Warden CD, Liu Z, Li H, Su L, Malkas LH, Chung. The Novel Ribonucleotide Reductase Inhibitor COH29 Inhibits DNA Repair In Vitro. . Mol Pharmacol. .2015 ;(87):996-1005

20. 2015 Lai MJ,Lee HY,Chuang HY,Chang LH,Tsai AC,Chen MC, Huang HL, Wu YW, Teng CM, Pan SL, Liu YM, Mehndiratta S, Liou. N-Sulfonyl-aminobiaryls as Antitubulin Agents and Inhibitors of Signal Transducers and Activators of . J Med Chem. .2015 ;(58):6549-6558

21. 2015 Liu YM,Lee HY,Lai MJ,Pan SL,Huang HL,Kuo FC, Chen MC, Liou JP.. Pyrimidinedione-mediated selective histone deacetylase 6 inhibitors with antitumor activity in colorectal cancer HCT116 cells. . Org Biomol Chem. .2015 ;(13):10226-10235

22. 2015 Chen MC,Huang HH,Lai CY,Lin YJ,Liou JP,Lai MJ, Li YH, Teng CM, Yang CR.. Novel histone deacetylase inhibitor MPT0G009 induces cell apoptosis and synergistic anticancer activity with tumor necrosis factor-related apoptosis-inducing ligand against human hepatocellular carcinoma. . Oncotarget .2015

23. 2015 Lin RD,Chen MC,Liu YL,Lin YT,Lu MK,Hsu FL, Lee MH.. New Whitening Constituents from Taiwan-Native Pyracantha koidzumii: . Int J Mol Sci. .2015 ;(16):28598-28613

24. 2014 Wu SY,Pan SL,Xiao ZY,Hsu JL,Chen MC,Lee KH, Teng CM. NPRL-Z-1, as a new topoisomerase II poison, induces cell apoptosis and ROS generation in human renal carcinoma cells. . Plos One .2014 ;(9):e11222

25. 2014 Lee HY,Tsai AC,Chen MC,Shen PJ,Cheng YC,Kuo CC, Pan SL, Liu YM, Liu JF, Yeh TK, Wang JC, Chang CY, Chang JY, Liou JP.. Azaindolylsulfonamides, with a More Selective Inhibitory Effect on Histone Deacetylase 6 Activity, Exhibit Antitumor Activity in Colorectal Cancer HCT116 Cells. . J Med Chem. .2014 ;(57):4009-4022

26. 2014 Mehndiratta S,Chiang YF,Lai MJ,Lee HY,Chen MC. Concise syntheses of 7-anilino-indoline-N-benzenesulfonamides as antimitotic and vascular disrupting agents. . Bioorg Med Chem. .2014

27. 2014 Chen CH,Chen MC,Wang JC,Tsai AC,Chen CS. Synergistic interaction between the HDAC inhibitor, MPT0E028, and sorafenib in liver cancer cells in vitro and in vivo. . Clin Cancer Res. .2014 ;(20):1274-1287

28. 2013 Chen MC,Chen CH,Liu YN,Wang HP,Pan SL,Teng CM. TW01001, a novel piperazinedione compound, induces mitotic arrest and autophagy in non-small cell lung cancer A549 cells. . Cancer Lett. .2013 ;(336):370-378

29. 2013 Chen MC,Chen CH,Wang JC,Tsai AC,Liou JP,Pan SL, Teng CM.. The HDAC inhibitor, MPT0E028, enhances erlotinib-induced cell death in EGFR-TKI-resistant NSCLC cells. . Cell Death Dis. .2013 ;(19):e810

30. 2012 Lai CY,Tsai AC,Chen MC,Chang LH,Sun HL,Chang YL, Chen CC, Teng CM, Pan SL.. Aciculatin induces p53-dependent apoptosis via MDM2 depletion in human cancer cells in vitro and in vivo. . PLoS One. .2012 ;(8):e42192

31. 2012 Chen MC,Pan SL,Shi Q,Xiao Z,Lee KH,Li TK, Teng CM.. QS-ZYX-1-61 induces apoptosis through topoisomerase II in human non-small-cell lung cancer A549 cells. . Cancer Sci. .2012 ;(103):80-87

32. 2011 Chen CH,Huang PH,Chu PC,Chen MC,Chou CC,Wang D, Kulp SK, Teng CM, Wang Q, Chen CS.. Energy restriction-mimetic agents induce apoptosis in prostate cancer cells in part through epigenetic activation of KLF6 tumor suppressor gene expression. . J Biol Chem. .2011 ;(286):9968-9976

33. 2011 Chen MC,Chen CH,Chuang HC,Kulp SK,Teng CM,Chen CS.. Novel mechanism by which histone deacetylase inhibitors facilitate topoisomerase IIα degradation in hepatocellular carcinoma cells. . Hepatology .2011 ;(53):148-159

研究計畫

計畫名稱
109 天然物對鉑類抗藥性膀胱癌之治療潛力及其分子作用機轉探討(2/3)
補助單位
科技部

計畫名稱
108 天然物對鉑類抗藥性膀胱癌之治療潛力及其分子作用機轉探討(1/3)
補助單位
科技部

計畫名稱
108 貴校中草藥臨床藥物研發博士學位學程博士生NGUYEN LINH NHAM君擬於109年4月27日至4月29日赴希臘塞薩羅尼基參加第20屆國際民族藥理學會,依本部補助國內研究生出席國際學術會議作業要點申請補助費用乙案,核定補助如說明,請查照
補助單位
科技部

計畫名稱
106 雙氫青蒿素衍生物在大腸直腸癌中抗癌作用與機制之探討
補助單位
科技部

計畫名稱
105 Tegafur衍生物在大腸直腸癌中抗癌作用之新藥開發與機制之探討(3/3)
補助單位
科技部

計畫名稱
105 Tegafur衍生物在大腸直腸癌中抗癌作用之新藥開發與機制之探討(3/3)
補助單位

計畫名稱
104 Tegafur衍生物在大腸直腸癌中抗癌作用之新藥開發與機制之探討(2/3)
補助單位
科技部

計畫名稱
104 Tegafur衍生物在大腸直腸癌中抗癌作用之新藥開發與機制之探討(2/3)
補助單位
科技部

計畫名稱
104 赴日本沖繩參加第18屆國際東洋醫學研討會-吳彤芸
補助單位
科技部

計畫名稱
103 TEGAFUR衍生物在大腸直腸癌中抗癌作用之新藥開發與機制之探討(1/3)
補助單位
科技部

計畫名稱
103 Tegafur衍生物在大腸直腸癌中抗癌作用之新藥開發與機制之探討(1/3)
補助單位
科技部

計畫名稱
102 TMU102-AE1-B43
補助單位
臺北醫學大學新聘教師計畫