林良宗(Lin, Liang-Tzung) 教授

Email
ltlin@tmu.edu.tw
現   職
國際研究組 組長
微生物免疫學科 教授

學經歷

學 歷

畢業學校與學位[修業時間]
Dalhousie University微生物與免疫 博士
2006/09~2011/05
University of Toronto醫學生物物理 碩士
2004/10~2006/08
McGill University微生物與免疫 學士
2000/09~2004/06

本校學術經歷

任職單位與職稱[起迄時間]
微生物免疫學科教授
2019/08/01~
微生物免疫學科副教授
2016/02/01~2019/07/31
微生物免疫學科助理教授
2012/09/01~2016/01/31
微生物免疫學科助理研究員
2012/08/21~2012/08/31

本校兼職教學行政經歷

服務單位與職稱[起迄時間]
國際研究組組長
2020/07/01 ~
國際研究組組長
2020/01/01 ~ 2020/03/31
國際醫學研究碩士學位學程副教授
2019/08/01 ~
國際醫學研究博士學位學程副教授
2019/08/01 ~
全球衛生暨衛生安全博士學位學程副教授
2018/08/01 ~
全球衛生暨發展碩士學位學程副教授
2017/08/01 ~
國際盟校組組長
2017/08/01 ~ 2020/03/31
校際合作組組長
2017/02/16 ~ 2017/07/31
國際盟校組籌備組組長
2017/02/16 ~ 2017/07/31

其它經歷

任職單位與職稱[起迄時間]
無資料!

專長與研究領域

學門領域
微生物及免疫學
學術專長

論文著作

清冊下載


1. 2020 Mwale PF,Lee CH,Lin LT,Leu SJ,Huang YJ,Chiang LC, Mao YC, Yang YY. Expression, Purification, and Characterization of Anti-Zika virus Envelope Protein: Polyclonal and Chicken-Derived Single Chain Variable Fragment Antibodies. . Int J Mol Sci. .2020 ;(21)

2. 2020 Lin LT. Special Issue "Recent Advances in Morbillivirus Vaccine Development and Oncolytic Virotherapy". . Viruses .2020 ;(12)

3. 2020 Tai CJ,,Jassey A, ,Liu CH,,Tai CJ,,Richardson CD,,Wong SH, Lin LT*. Targeting Autophagy Augments BBR-Mediated Cell Death in Human Hepatoma Cells Harboring Hepatitis C Virus RNA. . Cells .2020 ;(9)

4. 2019 Li Y,Ma MX,Qin B,Lin LT,Richardson CD,Feld J, McGilvray ID, Chen L. The Ubiquitin-Specific Protease 18 Promotes Hepatitis C Virus Production by Increasing Viral Infectivity. . Mediators Inflamm. .2019

5. 2019 Hung TC,Jassey A,Liu CH,Lin CJ,Lin C-C,Wong SH, Wang JY, Yen MH*, Lin LT*. Berberine inhibits hepatitis C virus entry by targeting the viral E2 glycoprotein . Phytomedicine .2019 ;(53):62-69

6. 2019 Jassey A,Liu CH,Changou CA,Richardson CD,Hsu HY,Lin LT*. Hepatitis C Virus Non-Structural Protein 5A (NS5A) Disrupts Mitochondrial Dynamics and Induces Mitophagy . Cells .2019 ;(8):1-17

7. 2019 Wong SH1, Jassey A1, Wang JY,Wang WC,Liu CH,Lin LT*. Virus-Like Particle Systems for Vaccine Development against Viruses in the Flaviviridae Family . Vaccines (Basel) .2019 ;(7):1-20

8. 2019 Wang JY,Lin CJ,Liu CH,Lin LT*. Use of Viral Entry Assays and Molecular Docking Analysis for the Identification of Antiviral Candidates against Coxsackievirus A16. . J Vis Exp. .2019

9. 2019 Lin LT,Uen WC,Choong CY,Shi YC,Lee BH,Tai CJ, Tai CJ*. Paris Polyphylla Inhibits Colorectal Cancer Cells via Inducing Autophagy and Enhancing the Efficacy of Chemotherapeutic Drug Doxorubicin. . Molecules .2019 ;(24):1-14

10. 2019 Tai CJ1,Liu CH1,Pan YC,Wong SH,Tai CJ,Richardson CD, Lin LT*. Chemovirotherapeutic Treatment Using Camptothecin Enhances Oncolytic Measles Virus-Mediated Killing of Breast Cancer Cells. . Sci Rep. .2019 ;(9):1-13

11. 2019 Mwale PF,Lee CH,Leu SJ,Lee YC, Wu HH,Lin LT, Lin TE, Huang YJ, Yang YY*. Antigenic epitopes on the outer membrane protein A of Escherichia coli identified with single-chain variable fragment (scFv) antibodies. . Appl Microbiol Biotechnol .2019 ;(103):5285-5299

12. 2019 Liu CH,Jassey A,Hsu HY,Lin LT*. Antiviral Activities of Silymarin and Derivatives. . Molecules .2019 ;(24):1-15

13. 2019 Kuo YT,Lin CC,Kuo HT,Hung JH,Liu CH,Jassey A, Yen MH, Wu SJ*, Lin LT*. Identification of baicalin from Bofutsushosan and Daisaikoto as a potent inducer of glucose uptake and modulator of insulin signaling-associated pathways . J Food Drug Anal .2019 ;(27):240-248

14. 2018 Hung TC,Jassey A,Lin CJ,Liu CH,Lin CC,Yen MH*, Lin LT*. Methanolic Extract of Rhizoma Coptidis Inhibits the Early Viral Entry Steps of Hepatitis C Virus Infection . Viruses .2018 ;(10):E669

15. 2018 Lin CJ,Liu CH,Wang JY,Lin CC,Li YF,Richardson CD, Lin LT*. Small molecules targeting coxsackievirus A16 capsid inactivate viral particles and prevent viral binding . Emerg Microbes Infect .2018 ;(7):162

16. 2018 Lee CH,Leu SJ,Lee YC,Liu CI,Lin LT,Mwale PF, Chiang JR, Tsai BY, Chen CC, Hung CS, Yang YY.. Characterization of Chicken-Derived Single Chain Antibody Fragments against Venom of Naja Naja Atra . Toxins (Basel) .2018 ;(10):E383

17. 2018 Lin LT1,Lai YJ1,Wu SC,Hsu WH,Tai CJ*. Optimal conditions for cordycepin production in surface liquid-cultured Cordyceps militaris treated with porcine liver extracts for suppression of oral cancer . J Food Drug Anal .2018 ;(26):135-144

18. 2018 Lin LT*. Emerging Viral Infectious Diseases & Oncolytic Viro-Immunotherapy . Impact .2018 ;(2018):48-50

19. 2017 Lee CH,Lee YC,Lee YL,Leu SJ,Lin LT,Chen CC, Chiang JR, Mwale PF, Tsai BY, Hung CS, Yang YY*. Single Chain Antibody Fragment against Venom from the Snake Daboia russelii formosensis . Toxins (Basel) .2017 ;(9):E347

20. 2017 Ha MN,Delpeut S,Noyce RS,Sisson G,Black KM,Lin LT, Bilimoria D, Plemper RK, Privé GG, Richardson CD.. Mutations in the fusion protein of measles virus that confer resistance to the membrane fusion inhibitors carbobenzoxy-d-Phe-l-Phe-Gly and AS-48 . J Virol .2017 ;(91):e01026-17

21. 2017 Chou ML,Wu JW,Gouel F,Jonneaux A,Timmerman K,Renn TY, Laloux C, Chang HM, Lin LT, Devedjian JC, Devos D*, Burnouf T*. Tailor-made purified human platelet lysate concentrated in neurotrophins for treatment of Parkinson's disease . Biomaterials .2017 ;(142):77-89

22. 2017 Jhan MK,Tsai TT,Chen CL,Tsai CC,Cheng YL,Lee YC, Ko CY, Lin YS, Chang CP, Lin LT, Lin CF*. Dengue virus infection increases microglial cell migration . Sci Rep .2017 ;(7):91

23. 2017 Liu CH,Lin CC,Hsu WC,Chung CY,Lin CC,Jassey A, Chang SP, Tai CJ, Tai CJ, Shields J, Richardson CD, Yen MH, Tyrrell DL, Lin LT*. Highly bioavailable silibinin nanoparticles inhibit HCV infection . Gut .2017 ;(66):1853-1861

24. 2016 Weng YJ,Husebekk A,Skogen B,Kjaer M,Lin LT,Burnouf T*. Anti-Human Platelet Antigen-1a Immunoglobulin G Preparation Intended to Prevent Fetal and Neonatal Alloimmune Thrombocytopenia . PLoS One .2016 ;(11):1-19

25. 2016 Lin LT,Richardson CD*. The Host Cell Receptors for Measles Virus and Their Interaction with the Viral Hemagglutinin (H) Protein. . Viruses .2016 ;(8):1-29

26. 2016 Lee CH,Lee YC,Leu SJ,Lin LT,Chiang JR,Hsu WJ, Yang YY*. Production and Characterization of Neutralizing Antibodies against Bungarus multicinctus Snake Venom . Appl Environ Microbiol .2016 ;(AEM):01876-16

27. 2016 Tzeng CW,Tzeng WS,Lin LT,Lee CW,Yen FL*,Lin CC*. Enhanced autophagic activity of artocarpin in human hepatocellular carcinoma cells through improving its solubility by a nanoparticle system . Phytomedicine .2016 ;(23):528-40

28. 2016 Chung CY,Liu CH,Burnouf T,Wang GH,Chang SP,Jassey A, Tai CJ, Tai CJ, Huang CJ, Richardson CD, Yen MH, Lin CC*, Lin LT*. Activity-based and fraction-guided analysis of Phyllanthus urinaria identifies loliolide as a potent inhibitor of hepatitis C virus entry . Antiviral Res .2016 ;(130):58-68

29. 2016 Tsai TT,Chen CL,Lin YS,Chang CP,Tsai CC,Cheng YL, Huang CC, Ho CJ, Lee YC, Lin LT, Jhan MK, Lin CF*. Microglia retard dengue virus-induced acute viral encephalitis . Sci Rep .2016 ;(6):1-10

30. 2016 Chung CY,Liu CH,Wang GH,Jassey A,Li CL,Chen L, Yen MH, Lin CC*, Lin LT*. (4R,6S)-2-Dihydromenisdaurilide is a Butenolide that Efficiently Inhibits Hepatitis C Virus Entry . Sci Rep .2016 ;(6):1-11

31. 2015 Lin LT,Chung CY,Hsu WC,Chang SP,Hung TC,Shields J, Russell RS, Lin CC, Li CF, Yen MH, Tyrrell DLJ, Lin CC*, Richardson CD*. Saikosaponin b2 is a Naturally Occurring Terpenoid That Efficiently Inhibits Hepatitis C Virus Entry . J Hepatol .2015 ;(62):541-548

32. 2015 Chou ML,Burnouf T,Chang SP,Hung TC,Lin CC,Richardson CD, Lin LT*. TnBP⁄Triton X-45 Treatment of Plasma for Transfusion Efficiently Inactivates Hepatitis C Virus. . PLoS One .2015 ;(10):e01178-00

33. 2015 Hsu WC,Chang SP,Lin LC,Li CL,Richardson CD,Lin CC*, Lin LT*. Limonium sinense and gallic acid suppress hepatitis C virus infection by blocking early viral entry . Antiviral Res .2015 ;(118):139-147

34. 2015 Lin LT1, Tai CJ1,Su CH,Chang FM,Choong CY,Wang CK*,Tai CJ*. The Ethanolic Extract of Taiwanofungus camphoratus (Antrodia camphorata) Induces Cell Cycle Arrest and Enhances Cytotoxicity of Cisplatin and Doxorubicin on Human Hepatocellular Carcinoma Cells . Biomed Res Int .2015 ;(2015):1-10

35. 2015 Tai CJ,Li CL,Tai C,Wang CK,Lin LT*. Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds . J Vis Exp .2015 ;(105):1-8

36. 2015 Lee CH,Lee YC,Liang MH,Leu SJ,Lin LT,Chiang JR, Yang YY*. Antibodies against Venom of the Snake Deinagkistrodon acutus . Appl Environ Microbiol .2015 ;(82):71-80

37. 2015 Chou ML,Lin LT,Devos D,Burnouf T*. Nanofiltration to remove microparticles and decrease the thrombogenicity of plasma: in vitro feasibility assessment . Transfusion .2015 ;(55):2433-44

38. 2015 Goodson WH 3rd*,Lowe L,Carpenter DO,Gilbertson M,Manaf Ali A,Lopez de Cerain Salsamendi A, (...), Lin LT, (...), Hu Z. Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead . Carcinogenesis .2015 ;(36):S254-96

39. 2015 Hu Z*,Brooks SA,Dormoy V,Hsu CW,Hsu HY,Lin LT, (...), Kleinstreuer N. Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: focus on the cancer hallmark of tumor angiogenesis . Carcinogenesis .2015 ;(36):S184-202

40. 2015 Mohammad RM*,Muqbil I,Lowe L,Yedjou C,Hsu HY,Lin LT, (...), Azmi AS. Broad targeting of resistance to apoptosis in cancer . Semin Cancer Biol .2015 ;(35):S78-S103

41. 2015 Tzeng CW,Tzeng WS,Lin LT,Lee CW,Yen MH,Yen FL*, Lin CC*. Artocarpus communis Induces Autophagic Instead of Apoptotic Cell Death in Human Hepatocellular Carcinoma Cells . Am J Chin Med .2015 ;(43):559-79

42. 2015 Block KI*,Gyllenhaal C,Lowe L*,Amedei A,Amin AR,Amin A, (...), LT Lin, (...), Zollo M. Designing a broad-spectrum integrative approach for cancer prevention and treatment . Semin Cancer Biol .2015 ;(35):S276-304

43. 2014 Lin LT*,Hsu WC,Lin CC*. Antiviral Natural Products and Herbal Medicines. . J Tradit Complement Med. .2014 ;(4):24-35

44. 2014 Ng LT1, Lin LT1,Chen CL,Chen HW,Wu SJ*,Lin CC*. Anti-melanogenic effects of δ-tocotrienol are associated with tyrosinase-related proteins and MAPK signaling pathway in B16 melanoma cells . Phytomedicine .2014 ;(21):978-983

45. 2014 Tzeng CW,Yen FL,Lin LT,Lee CW,Yen MH,Tzeng WS*, Lin CC*. Antihepatoma activity of Artocarpus communis is higher in fractions with high artocarpin content . ScientificWorldJournal .2014 ;(978525)

46. 2013 Lin LT,Chen TY,Lin SC,Chung CY,Lin TC,Wang GH, Anderson R, Lin CC*, Richardson CD*. Broad-spectrum antiviral activity of chebulagic acid and punicalagin against viruses that use glycosaminoglycans for entry . BMC Microbiology .2013 ;(13):1-15

47. 2013 Lin LT,Wu SJ*,Lin CC*. The Anticancer Properties and Apoptosis‑inducing Mechanisms of Cinnamaldehyde and the Herbal Prescription Huang‑Lian‑Jie‑Du‑Tang (黃連解毒湯 Huáng Lián Jiě Dú Tang) in Human Hepatoma Cells. . J Tradit Complement Med. .2013 ;(3):227-233

48. 2013 Lin LT,Tai CJ,Chang SP,Chen JL,Wu SJ*,Lin CC*. Cinnamaldehyde-induced Apoptosis in Human Hepatoma PLC/PRF/5 Cells Involves the Mitochondrial Death Pathway and is Sensitive to Inhibition by Cyclosporin A and z-VAD-fmk . Anticancer Agents Med Chem .2013 ;(13):1565-1574

49. 2012 Lin CC,Lin LT,Yen MH,Cheng JT,Hsing CH*,Yeh CH*. Renal Protective Effect of Xiao-Chai-Hu-Tang on Diabetic Nephropathy of Type 1-Diabetic Mice. . Evid Based Complement Alternat Med. .2012 ;(2012):984024

50. 2011 Noyce RS,Bondre DG,Ha MN,Lin LT,Sisson G,Tsao MS, Richardson CD*. Tumor cell marker PVRL4 (nectin 4) is an epithelial cell receptor for measles virus . PLoS Pathog. .2011 ;(7):e10022-40

51. 2011 Lin LT1, Chen TY1,Chun CY,Noyce RS,Grindley TB,McCormick C,Lin TC, Wang GH, Lin CC*, Richardson CD*. Hydrolyzable tannins (chebulagic acid and punicalagin) target viral glycoprotein-glycosaminoglycan interactions to inhibit herpes simplex virus 1 entry and cell-to-cell spread . J Virol .2011 ;(85):4386-4398

52. 2010 Lin LT,Dawson PW,Richardson CD. Viral interactions with macroautophagy: a double-edged sword . Virology .2010 ;(402):1-10

53. 2010 Vivithanaporn P,Maingat F,Lin LT,Na H,Richardson CD,Agrawal B, Cohen EA, Jhamandas JH, Power C*. Hepatitis C virus core protein induces neuroimmune activation and potentiates Human Immunodeficiency Virus-1 neurotoxicity . PLoS One .2010 ;(5):e12856

54. 2010 Lin LT,Noyce RS,Pham TN,Wilson JA,Sisson GR,Michalak TI, Mossman KL, Richardson CD*. Replication of Subgenomic HCV Replicons in Mouse Fibroblasts is Facilitated by Deletion of Interferon Regulatory Factor-3 and Expression of Liver-Specific MicroRNA-122 . J Virol .2010 ;(84):9170-9180

研究計畫

計畫名稱
109 針對C型肝炎引發之肝細胞癌開發之溶瘤麻疹病毒精準醫療(3/3)
補助單位
科技部

計畫名稱
108 開發裝載伊波拉病毒醣蛋白之類病毒作為抗絲狀病毒入侵細胞抑制劑之研究模型
補助單位
奇美醫療財團法人奇美醫院

計畫名稱
108 針對C型肝炎引發之肝細胞癌開發之溶瘤麻疹病毒精準醫療(2/3)
補助單位
科技部

計畫名稱
107 以多管齊下的方式開發新型抗愛滋病毒藥物(2/2)
補助單位

計畫名稱
107 抗黃病毒入侵細胞抑制劑之開發研究
補助單位
奇美醫療財團法人奇美醫院

計畫名稱
107 針對C型肝炎引發之肝細胞癌開發之溶瘤麻疹病毒精準醫療(1/3)
補助單位
科技部

計畫名稱
106 以多管齊下的方式開發新型抗愛滋病毒藥物(1/2)
補助單位
科技部

計畫名稱
106 天然小分子增強劑提升溶瘤麻疹病毒載體抗癌之研究
補助單位
奇美醫療財團法人奇美醫院

計畫名稱
106 以可量產之商用半導體製程建立奈米線場效電晶體血液產品病毒檢測平台 (重點主題:A2)(2/3)
補助單位
科技部

計畫名稱
106 以高效率類病毒平台開發新型抗C型肝炎病毒入侵細胞抑制劑
補助單位
科技部

計畫名稱
106 醫學科學研究所博士班研究生Alagie君擬於106年9月25日至9月28日赴美國波士頓(Boston,Massachuseetts)參加第二十四屆C型肝炎及相關病毒國際研討會
補助單位
科技部

計畫名稱
105 Use of Oncolytic Measles Virus Vector for Targeted Virotherapy of Hepatocellular Carcinomas
補助單位
科技部

計畫名稱
105 樟芝萃取劑抗人類免疫缺陷病毒效力之前臨床模式驗證研究計畫
補助單位
台灣原生藥用植物股份有限公司

計畫名稱
105 以可量產之商用半導體製程建立奈米線場效電晶體血液產品病毒檢測平台 (重點主題:A2)(1/3)
補助單位
科技部

計畫名稱
105 溶瘤麻疹病毒抗乳腺癌治療之開發研究(3/3)
補助單位
科技部

計畫名稱
105 溶瘤麻疹病毒抗乳腺癌治療之開發研究(3/3)
補助單位
科技部

計畫名稱
104 Development of Nano-formulated Silibinin As Inhibitor of HCV CellTo-Cell Spread
補助單位
科技部

計畫名稱
104 抗高血糖天然藥物開發抗糖尿病治療之研究
補助單位
奇美醫療財團法人奇美醫院

計畫名稱
104 溶瘤麻疹病毒抗乳腺癌治療之開發研究(2/3)
補助單位
科技部

計畫名稱
104 溶瘤麻疹病毒抗乳腺癌治療之開發研究(2/3)
補助單位
科技部

計畫名稱
103 前臨床模式評估牛樟芝酒精萃取物與標準化療藥物在人類肺癌細胞之整合抑癌效力
補助單位
臺北醫學大學附設醫院

計畫名稱
103 溶瘤麻疹病毒抗乳腺癌治療之開發研究(1/3)
補助單位
科技部

計畫名稱
103 溶瘤麻疹病毒抗乳腺癌治療之開發研究(1/3)
補助單位
科技部

計畫名稱
102 先天性免疫調節劑高氏柴胡多醣體之分子特性與其免疫調節和抗病毒藥效之評估(2/2)
補助單位
行政院國家科學委員會

計畫名稱
102 先天性免疫調節劑高氏柴胡多醣體之分子特性與其免疫調節和抗病毒藥效之評估(2/2)
補助單位
科技部

計畫名稱
101 先天性免疫調節劑高氏柴胡多醣體之分子特性與其免疫調節和抗病毒藥效之評估(1/2)
補助單位
行政院國家科學委員會

計畫名稱
101 TMU101-AE1-B12
補助單位
學校

計畫名稱
101 天然藥物輔助溶瘤病毒抗癌治療之開發研究
補助單位
臺北醫學大學