柯瓊媛(Ko, Chiung-Yuan) 助理教授

Email
ko680108@tmu.edu.tw
現   職
神經再生醫學博士學位學程 助理教授

學經歷

學 歷

畢業學校與學位[修業時間]
國立成功大學基礎醫學研究所 博士
2003/08~2009/04

本校學術經歷

任職單位與職稱[起迄時間]
神經再生醫學博士學位學程助理教授
2016/03/12~
神經再生醫學博士學位學程專案助理研究員
2014/02/01~2016/03/11

本校兼職教學行政經歷

服務單位與職稱[起迄時間]
無資料!

其它經歷

任職單位與職稱[起迄時間]
臺北醫學大學博士後研究員
2013/11~2014/01

專長與研究領域

學門領域
學術專長

論文著作

清冊下載


1. 2020 Chen TC,Chuang JY,Ko CY,Kao TJ,Yang PY,Yu CH, Liu MS, Hu SL, Tsai YT, Chan H, Chang WC, Hsu TI. AR ubiquitination induced by the curcumin analog suppresses growth of temozolomide-resistant glioblastoma through disrupting GPX4-Mediated redox homeostasis . Redox Biology .2020 ;(30):101413

2. 2019 Yang WB,Chuang JY,Ko CY,Chang WC,Hsu TI. Dehydroepiandrosterone induces Temozolomide resistance through modulating phosphorylation and acetylation of Sp1 in glioblastoma . Molecular Neurobiology .2019 ;(56):2301-2313

3. 2019 E2f1 regulates the induction of promyelocytic leukemia zinc finger transcription in neuronal differentiation of pluripotent P19 embryonal carcinoma cells . Biochemical and Biophysical Research Communications .2019 ;(512):629-634

4. 2019 Wang SM,Lin HY,Chen YL,Hsu TI,Chuang JY,Kao TJ, Ko CY. CCAAT/enhancer-binding protein delta regulates the stemness of glioma stem-like cells through activating PDGFA expression upon inflammatory stimulation . Journal of Neuroinflammation .2019 ;(16):146-157

5. 2019 Lin HY,Ko CY,Kao TJ,Yang WB,Tsai YT,Chuang JY, Hu SL, Yang PY, Lo WL, Hsu TI. CYP17A1 maintains the survival of glioblastomas by regulating SAR1-mediated endoplasmic reticulum health and redox homeostasis . Cancers .2019 ;(11):E1378

6. 2018 Ko CY,Lin CH,Chuang JY,Chang WC,Hsu TI. MDM2 Degrades Deacetylated Nucleolin Through Ubiquitination to Promote Glioma Stem-Like Cell Enrichment for Chemotherapeutic Resistance . Molecular Neurobiology .2018 ;(55):3211-3223

7. 2018 Wang SM,Lim SW,Wang YH,Lin HY,Lai MD,Ko CY, Wang JM. Astrocytic CCAAT/Enhancer-binding protein delta contributes to reactive oxygen species formation in neuroinflammation . Redox Biology .2018 ;(16):104-112

8. 2018 Liu TC,Lee YC,Ko CY,Liu RS,Ke CC,Lo YC, Hong PS, Chu CY, Chang CW, Wu PW, Chen YY, Chen SY. Highly sensitive/selective 3D nanostructured immunoparticle-based interface on a multichannel sensor array for detecting amyloid-beta in Alzheimer's disease . Theranostics .2018 ;(8):4210-4225

9. 2017 Chang KY,Hsu TI,Hsu CC,Tsai SY,Liu JJ, Chou SW, Liu MS, Liou JP, Ko CY, Chen KY, Hung JJ, Chang WC, Chuang CK, Kao TJ, Chuang JY. Specificity protein 1-modulated superoxide dismutase 2 enhances temozolomide resistance in glioblastoma, which is independent of O6-methylguanine-DNA methyltransferase . Redox Biology .2017 ;(13):655-664

10. 2017 Chu YY,Ko CY,Wang SM,Lin PI,Wang HY,Lin WC, Wu DY, Wang LH and Wang JM. Bortezomib-induced miRNAs direct epigenetic silencing of locus genes and trigger apoptosis in leukemia . Cell Death & Disease .2017 ;(8):e3167

11. 2017 Chuang JY,Lo WL,Ko CY,Chou SY,Chen RM,Chang KY, Hung JJ, Su WC, Chang WC, Hsu TI. Upregulation of CYP17A1 by Sp1-mediated DNA demethylation confers Temozolomide resistance through DHEA-mediated protection in glioma . Oncogenesis .2017 ;(6):e339

12. 2017 Huang TC, Lee PT,Wu MH, Huang CC,Ko CY,Lee YC, Lin DY, Cheng YW, Lee KH. Distinct roles and differential expression levels of Wnt5a mRNA isoforms in colorectal cancer cells . PLoS One .2017 ;(12):e0181034

13. 2017 Jhan MK,Tsai TT,Chen CL,Chen CL,Cheng YL,Lee YC, Ko CY, Lin YS, Chang CP, Lin LT, Lin CF. Dengue virus infection increases microglial cell migration . Scientific Reports .2017 ;(7):91-101

14. 2016 Ko CY,Wang WL,Li CF,Jeng YM,Chu YY,Wang HY, Tseng JT, Wang JM. IL-18-induced interaction between IMP3 and HuR contributes to COX-2 mRNA stabilization in acute myeloid leukemia . Journal of Leukocyte Biology .2016 ;(99):131-141

15. 2016 Chu YY,Ko CY,Wang WJ,Wang SM,Gean PW,Kuo YM, Wang JM. Astrocytic CCAAT/enhancer binding protein δ regulates neuronal viability and spatial learning ability via miR-135a . .2016 ;(53):4173-4188

16. 2016 Wang SM,Hsu JC,Ko CY,Chiu NE,Kan WM,Lai MD, Wang JM. Astrocytic CCAAT/enhancer-binding protein delta contributes to glial scar formation and impairs functional recovery after spinal cord injury . Molecular Neurobiology .2016 ;(53):5912-5927

17. 2016 Hsu CC,Chang WC,Hsu TI,Liu JJ,Yeh SH,Wang JY, Liou JP, Ko CY, Chang KY, Chuang JY. Suberoylanilide hydroxamic acid represses glioma stem-like cells . Journal of Biomedical Science .2016 ;(23):81-92

18. 2015 Wang SM,Lee YC,Ko CY,Lai MD,Lin DY,Pao PC, Chi JY, Hsiao YW, Liu TL, Wang JM. Increase of Zinc Finger Protein 179 in response to CCAAT/enhancer binding protein delta conferring an antiapoptotic effect in astrocytes of Alzheimer's disease . Molecular Neurobiology .2015 ;(51):370-382

19. 2015 Ko CY,Chu YY,Narumiya S,Chi JY,Furuyashiki T,Aoki T, Wang SM, Chang WC, Wang JM. The CCAAT/enhancer-binding protein delta/miR135a/thrombospondin 1 axis mediates PGE2-induced angiogenesis in Alzheimer's disease . Neurobiology of Aging .2015

20. 2015 Ko CY,Chang WC,Wang JM. Biological roles of CCAAT/Enhancer-binding protein delta during inflammation . Journal of Biomedical Science .2015 ;(22):6-13

21. 2015 Li CF,Tsai HH,Ko CY,Pan YC,Yen CJ,Lai HY, Yuh CH, Wu WC, Wang JM. HMDB and 5-AzadC Combination Reverses Tumor Suppressor CCAAT/Enhancer-Binding Protein Delta to Strengthen the Death of Liver Cancer Cells . Molecular Cancer Therapeutics .2015 ;(14):2623-2633

22. 2014 Ko CY,Wang WL,Wang SM,Chu YY,Chang WC,Wang JM. Glycogen synthase kinase-3β-mediated CCAAT/enhancer-binding protein delta phosphorylation in astrocytes promotes migration and activation of microglia/macrophages . Neurobiology of Aging .2014 ;(35):24-34

23. 2014 Chuang CH,Wang WJ,Li CF,Ko CY,Chou YH,Chuu CP, Cheng TL, Wang JM. The combination of the prodrugs perforin-CEBPD and perforin-granzyme B efficiently enhances the activation of caspase signaling and kills prostate cancer . Cell Death and Disease .2014 ;(5):e1220-e1230

24. 2014 Wang SM,Lee YC,Ko CY,Lai MD,Lin DY,Pao PC, Chi CY, Hsiao YW, Wang JM. Increase of Zinc Finger Protein 179 in response to CCAAT/enhancer binding protein delta conferring an antiapoptotic effect in astrocytes of Alzheimer's disease . Molecular Neurobiology .2014

25. 2012 Ko CY,Chang LH,Lee YC,Sterneck E,Cheng CP,Chen SH, Huang AM, Tseng JT, Wang JM. CCAAT/enhancer binding protein delta (CEBPD) elevating PTX3 expression inhibits macrophage-mediated phagocytosis of dying neuron cells . Neurobiology of Aging .2012 ;(33):e11-e25

26. 2010 Pan YC,Li CF,Ko CY,Pan MH,Chen PJ,Tseng JT, Wu WC, Chang WC, Huang AM, Sterneck E, Wang JM. CEBPD reverses RB/E2F1-mediated gene repression and participates in HMDB-induced apoptosis of cancer cells . Clinical Cancer Research .2010 ;(16):5770-5780

27. 2008 Lai PH,Wang WL,Ko CY,Lee YC,Yang WM,Shen TW, Chang WC, Wang JM. HDAC1/HDAC3 modulates PPARG2 transcription through the sumoylated CEBPD in hepatic lipogenesis . Biochimica et Biophysica Acta (BBA) - Molecular Cell Research .2008 ;(1783):1803-1814

28. 2008 Ko CY,Hsu HC,Shen MR,Chang WC,Wang JM. Epigenetic silencing of CCAAT/Enhancer-binding protein δ activity by YY1/Polycomb group/DNA methyltransferase complex . Journal of Biological Chemistry .2008 ;(283):30919-30932

29. 2006 Wang JM,Ko CY,Chen LC,Wang WL,Chang WC. Functional role of NF-IL6beta and its sumoylation and acetylation modifications in promoter activation of cyclooxygenase 2 gene . Nucleic Acids Research .2006 ;(34):217-231

研究計畫

計畫名稱
108 探討脊髓損傷後轉錄因子Cebpd在星狀膠質細胞中調控纖維化疤痕的形成
補助單位
奇美醫療財團法人奇美醫院

計畫名稱
108 探討神經發炎中星狀膠質細胞內CEBPD活化的小分子核糖核酸及其對血管新生的影響(II)(1/2)
補助單位
科技部

計畫名稱
107 探討多形性膠質母細胞瘤中轉錄因子CEBPD參與在細胞存活中的角色
補助單位
奇美醫療財團法人奇美醫院

計畫名稱
107 探討神經發炎中星狀膠質細胞內CEBPD活化的小分子核糖核酸及其對血管新生的影響
補助單位
科技部

計畫名稱
106 探討轉錄因子CEBPD在星狀膠質細胞中參與神經發炎誘發之活性氧形成
補助單位
奇美醫療財團法人奇美醫院

計畫名稱
106 發炎微環境調控神經膠質瘤幹細胞化之機制探討(2/2)
補助單位
科技部

計畫名稱
105 新聘教師研究補助
補助單位
臺北醫學大學

計畫名稱
105 發炎微環境調控神經膠質瘤幹細胞化之機制探討(1/2)
補助單位
科技部