李崑豪(Lee, Kuen-Haur) 教授

Email
khlee@tmu.edu.tw
現   職
癌症生物學與藥物研發研究所 所長
癌症生物學與藥物研發博士學位學程 教授

學經歷

學 歷

畢業學校與學位[修業時間]
成功大學基礎醫學研究所 博士
2004/09~2009/10
中山大學生物醫學研究所 碩士
2002/09~2004/09
中山大學海洋資源學系 學士
1998/09~2002/07

本校學術經歷

任職單位與職稱[起迄時間]
癌症生物學與藥物研發博士學位學程教授
2022/02/01~
癌症生物學與藥物研發研究所副教授
2018/12/01~2022/01/31
癌症生物學與藥物研發博士學位學程副教授
2016/08/01~2018/11/30
癌症生物學與藥物研發博士學位學程助理教授
2012/09/01~2016/07/31
癌症生物學與藥物研發博士學位學程助理研究員
2012/08/16~2012/08/31

本校兼職教學行政經歷

服務單位與職稱[起迄時間]
癌症生物學與藥物研發博士學位學程暫代主任
2023/03/14 ~ 2024/03/13
癌症生物學與藥物研發研究所副教授
2022/02/01 ~
癌症生物學與藥物研發博士學位學程副教授
2019/01/01 ~ 2022/01/31
癌症生物學與藥物研發研究所所長
2018/08/01 ~
癌症生物學與藥物研發研究所籌備處主任
2017/10/01 ~ 2018/07/31
癌症生物學與藥物研發博士學位學程主任
2017/03/14 ~ 2023/03/13

其它經歷

任職單位與職稱[起迄時間]
美國俄亥俄州立大學博士後研究員
2010/01/01~2012/07/31

專長與研究領域

學門領域
癌症分子機制研究
抗癌藥物之分子機制研究
微小核糖核酸致癌與抑癌機轉研究
藥物誘導之基因表現圖譜探勘
學術專長
Cell culture
Cell viability and cytotoxicity assay
RT-PCR
Quantitative RT-PCR
Western blot

論文著作

清冊下載


1. 2023 Ho CB,Tsai JT,Chen CY,Shiah HS,Chen HY,Ting LL, Kuo CC, Lai IC, Lai HY, Chung CL, Lee KL, Tzeng HE, Lee KH, Lee HL, Chen SW, Chiou JF. Effectiveness of Stereotactic Ablative Radiotherapy for Systemic Therapy Respondents with Inoperable Pulmonary Oligometastases and Oligoprogression . Diagnostics .2023 ;(13):1597-1597

2. 2023 Dang HH,Ta HDK,Nguyen TTT,Wang CY,Lee KH,Le NQK. Identification of a Novel Eight-Gene Risk Model for Predicting Survival in Glioblastoma: A Comprehensive Bioinformatic Analysis . Cancers .2023 ;(15):3899-3899

3. 2023 Khoa Ta HD,Nguyen NN,Ho DKN,Nguyen HD,Ni YC,Yee KX, Pan SR, Nguyen HS, Thai Hoang Phuoc T, Chen MJ, Lee KH. Association of diabetes mellitus with early-onset colorectal cancer: A systematic review and meta-analysis of 19 studies including 10 million individuals and 30,000 events . Diabetes Metab Syndr. .2023 ;(17):102828-102828

4. 2023 Chan CY,Ni YC,Nguyen HD,Wu YF,Lee KH. Identification of Potential Protein Targets in Extracellular Vesicles Isolated from Chemotherapy-Treated Ovarian Cancer Cells . Curr Issues Mol Biol. .2023 ;(45):7417-7431

5. 2022 Tsai YT,Li CY,Huang YH,Chang TS,Lin CY,Chuang CH, Wang CY, Anuraga G, Chang TH, Shih TC, Lin ZY, Chen YL, Chung I, Lee KH, Chang CC, Sung SY, Yang KH, Tsui WL, Yap CV, Wu MH. Galectin-1 orchestrates an inflammatory tumor-stroma crosstalk in hepatoma by enhancing TNFR1 protein stability and signaling in carcinoma-associated fibroblasts . Oncogene .2022 ;(41):3011-3023

6. 2022 Dang HH,Ta HDK,Nguyen TTT,Anuraga G,Wang CY, ,Lee KH, Le NQK. Prospective role and immunotherapeutic targets of sideroflexin protein family in lung adenocarcinoma: evidence from bioinformatics validation . Funct Integr Genomics. .2022 ;(22):1057-1072

7. 2021 Tsai WL,Wang CY,Lee YC,Tang WC,Anuraga G,Ta HDK, Wu YF, Lee KH. A New Light on Potential Therapeutic Targets for Colorectal Cancer Treatment . Biomedicines .2021 ;(9):1438-1438

8. 2021 Prayugo FB,Kao TJ,Anuraga G,Ta HDK,Chuang JY,Lin LC, Wu YF, Wang CY, Lee KH. Expression Profiles and Prognostic Value of FABPs in Colorectal Adenocarcinomas . Biomedicines .2021 ;(9):1460-1460

9. 2021 Ta HDK,Xuan DTM,Tang WC,Anuraga G,Ni Yi-Chun,Pan SR, Wu YF, Fitriani F, E Hermanto, Muhammad A, Vivin A, Wang CY and Lee KH. Novel insights into the prognosis and immunological value of the SLC35A (Solute Carrier 35A) Family Genes in human Breast Cancer . Biomedicines .2021

10. 2021 Khoa Ta HD,Tang WC,Phan NN,Anuraga G,Hou SY,Chiao CC, Liu YH, Wu YF, Lee KH, Wang CY. Analysis of LAGEs Family Gene Signature and Prognostic Relevance in Breast Cancer . Diagnostics (Basel) .2021

11. 2021 Anuraga G,Tang WC,Phan NN,Ta HDK,Liu YH,Wu YF, Lee KH, Wang CY. Comprehensive Analysis of Prognostic and Genetic Signatures for General Transcription Factor III (GTF3) in Clinical Colorectal Cancer Patients Using Bioinformatics Approaches . Curr Issues Mol Biol .2021

12. 2021 Chen MY,Yadav VK,Chu YC,Ong JR,Huang TY,Lee KF, Lee KH, Yeh CT, Lee WH. Hydroxychloroquine (HCQ) Modulates Autophagy and Oxidative DNA Damage Stress in Hepatocellular Carcinoma to Overcome Sorafenib Resistance via TLR9/SOD1/hsa-miR-30a-5p/Beclin-1 Axis . Cancers (Basel) .2021

13. 2021 Ta HDK,Wang WJ,Phan NN,An Ton NT,Anuraga G,Ku SC, Wu YF, Wang CY, Lee KH. Potential Therapeutic and Prognostic Values of LSM Family Genes in Breast Cancer . Cancers .2021 ;(13):4902-4902

14. 2021 Wu YF,Wang CY,Tang WC,Lee YC,Ta HDK,Lin LC, Pan SR, Ni YC, Anuraga G, Lee KH. Expression Profile and Prognostic Value of Wnt Signaling Pathway Molecules in Colorectal Cancer . Biomedicines .2021 ;(9):1331-1331

15. 2020 Ekanem TI,Tsai WL,Lin YH,Tan WQ,Chang HY, Huang TC, Chen HY, Lee KH. Identification of the Effects of Aspirin and Sulindac Sulfide on the Inhibition of HMGA2-Mediated Oncogenic Capacities in Colorectal Cancer . Molecules .2020 ;(25):3826-3826

16. 2020 Wu CC,Ekanem TI,Phan NN,Loan DTT,Hou SY,Lee KH, Wang CY. Gene signatures and prognostic analyses of the Tob/BTG pituitary tumor-transforming gene (PTTG) family in clinical breast cancer patients . Int J Med Sci. .2020 ;(17):3112-3124

17. 2020 Kuo CJ ,Lee KH ,Huang CC ,Wang IF,Hsieh CCJ,Lin HC, Lee YC. Purα regulates the induction of Znf179 transcription during neuronal differentiation . Biochemical and Biophysical Research Communications .2020

18. 2019 Ekanem TI,Huang CC,Wu MH,Lin DY,Lai WT,Lee KH. Glycidamide Promotes the Growth and Migratory Ability of Prostate Cancer Cells by Changing the Protein Expression of Cell Cycle Regulators and Epithelial-to-Mesenchymal Transition (EMT)-Associated Proteins with Prognostic Relevance. . Int J Mol Sci. .2019 ;(20)

19. 2019 Lin HC,Ko CY,Lee KH,Chen IH,Kao TJ,Chang WC, Hsu TI, Lee YC. E2f1 regulates the induction of promyelocytic leukemia zinc finger transcription in neuronal differentiation of pluripotent P19 embryonal carcinoma cells. . Biochem Biophys Res Commun. .2019 ;(512):629-634

20. 2019 Wang CH,Hung PW,Chiang CW,Lombès M,Chen CH,Lee KH, Lo YC, Wu MH, Chang WC, Lin DY. Identification of two independent SUMO-interacting motifs in Fas-associated factor 1 (FAF1): Implications for mineralocorticoid receptor (MR)-mediated transcriptional regulation. . Biochim Biophys Acta Mol Cell Res. .2019 ;(1866):1282-1297

21. 2019 Hung KC,Huang TC,Cheng CH,Cheng YW,Lin DY,Fan JJ, Lee KH. The Expression Profile and Prognostic Significance of Metallothionein Genes in Colorectal Cancer. . Int J Mol Sci. .2019 ;(20)

22. 2019 Integration of Bioinformatics Resources Reveals the Therapeutic Benefits of Gemcitabine and Cell Cycle Intervention in SMAD4-Deleted Pancreatic Ductal Adenocarcinoma. . Genes .2019 ;(10)

23. 2019 Fan JJ,Hsu WH,Lee KH,Chen KC,Lin CW,Lee YA, Ko TP, Lee LT, Lee MT, Chang MS, Cheng CH. Dietary Flavonoids Luteolin and Quercetin Inhibit Migration and Invasion of Squamous Carcinoma through Reduction of Src/Stat3/S100A7 Signaling. . Antoxidants .2019 ;(8)

24. 2019 Huang YM,Cheng CH,Pan SL,Yang PM,Lin DY,Lee KH. Gene Expression Signature-Based Approach Identifies Antifungal Drug Ciclopirox As a Novel Inhibitor of HMGA2 in Colorectal Cancer. . Biomolecules .2019 ;(9)

25. 2018 Wu MH,Luo JD,Wang WC,Chang TH,Hwang WL, Lee KH, Liu SY, Yang JW, Chiou CT, Chang CH, Chiang WF. Risk analysis of malignant potential of oral verrucous hyperplasia: A follow-up study of 269 patients and copy number variation analysis. . Head Neck. .2018 ;(40):1046-1056

26. 2018 Lee YC,Huang WC,Lin JH,Kao TJ,Lin HC,Lee KH, Lin HC, Shen CJ, Chang WC, Huang CC. Znf179 E3 ligase-mediated TDP-43 polyubiquitination is involved in TDP-43- ubiquitinated inclusions (UBI) (+)-related neurodegenerative pathology. . J Biomed Sci. .2018 ;(25):76-76

27. 2017 Lee KH,Chen CL,Lee CH,Kao TJ,Chen KY. Znf179 induces differentiation and growth arrest of human primary glioblastoma multiform in a p53-dependant cell cycle pathway. . Scientific Reports .2017 ;(7):4787-4797

28. 2017 Wu MH,Chen YL,Lee KH, Chang CC, Cheng TM, Wu SY. Glycosylation-dependent galectin-1/neuropilin-1 interactions promote liver fibrosis through activation of TGF-β- and PDGF-like signals in hepatic stellate cells. . Scientific Reports .2017 ;(7):11006-11006

29. 2017 Huang TC,Lee PT,Wu MH,Huang CC,Ko CY,Lee YC, Lin DY, Cheng YW, Lee KH. Distinct roles and differential expression levels of Wnt5a mRNA isoforms in colorectal cancer cells. . PLoS One .2017 ;(12):e0181034-e0181034

30. 2017 Chiang WF,Cheng TM,Chang CC,Pan SH,Changou CA,Chang TH, Lee KH, Wu SY, Chen YF, Chuang KH, Shieh DB, Chen YL, Tu CC, Tsui WL and Wu MH. Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) promotes EGF receptor signaling of oral squamous cell carcinoma metastasis via the complex N-glycosylation. . Oncogene .2017

31. 2016 Kao CY,Yang PM,Wu MH,Huang CC,Lee YC,Lee KH. Heat shock protein 90 is involved in the regulation of HMGA2-driven growth and epithelial-to-mesenchymal transition of colorectal cancer cells. . PeerJ .2016 ;(4):1-21

32. 2016 Tsou JH,Yang YC,Pao PC,Lin HC,Huang NK,Lin ST, Hsu KS, Yeh CM, Lee KH, Kuo CJ, Yang DM, Lin JH, Chang WC, Lee YC. Important Roles of Ring Finger Protein 112 in Embryonic Vascular Development and Brain Functions. . Mol Neurobiol .2016

33. 2016 Yang CP,Kuo YL,Lee YC,Lee KH,Chiang CW,Wang JM, Hsu CC, Chang WC, Lin DY. RINT-1 interacts with MSP58 within nucleoli and plays a role in ribosomal gene transcription. . Biochem Biophys Res Commun. .2016

34. 2016 Chen IC,Lee KH,Hsu YH,Wang WR,Chen CM,Cheng YW. Expression Pattern and Clinicopathological Relevance of the Indoleamine 2,3-Dioxygenase 1/Tryptophan 2,3-Dioxygenase Protein in Colorectal Cancer. . Dis Markers .2016 ;(2016):1-9

35. 2016 Chang CF,Lee YC,Lee KH,Lin HC,Chen CL,Shen CJ, Huang CC. Therapeutic effect of berberine on TDP-43-related pathogenesis in FTLD and ALS . J Biomed Sci. .2016 ;(23):72-72

36. 2015 Liu CH,Tang WC,Sia P,Huang CC,Yang PM,Wu MH, Lai IL, Lee KH. Berberine Inhibits the Metastatic Ability of Prostate Cancer Cells by Suppressing Epithelial-to-Mesenchymal Transition (EMT)-Associated Genes with Predictive and Prognostic Relevance. . International Journal of Medical Sciences .2015 ;(12):63-71

37. 2015 Jhuang HJ,Hsu WH,Lin KT,Hsu SL,Wang FS,Chou CK, Lee KH, Tsou AP, Lai JM, Yeh SF and Huang CY. Gluconeogenesis, lipogenesis, and HBV replication are commonly regulated by PGC-1α-dependent pathway. . Oncotarget .2015 ;(6):7788-7803

38. 2015 Lin CH,Li HY,Lee YC,Calkins MJ,Lee KH,Yang CN, Lu PJ. Landscape of Pin1 in cell cycle. . Experimental Biology and Medicine .2015 ;(240):403-408

39. 2015 Su YH,Tang WC,Cheng YW,Sia P,Huang CC,Lee YC, Jiang HY, Wu MH, Lai IL, Lee JW, Lee KH. Targeting of multiple oncogenic signaling pathways by Hsp90 inhibitor alone or in combination with berberine for treatment of colorectal cancer. . BBA-Mol Cell Res. .2015 ;(1853):2261-2272

40. 2015 Lee YC,Lee JW,Huang CC,Wu MH,Lee KH. Data supporting the identification of compound for inhibition of survivin of colorecta lcancer by using ingenuity pathway analysis of gene expression profiling of colorectal cancer tissues. . Data in Brief .2015 ;(4):235-238

41. 2015 Tang WC,Lee KH. Inhibitory effects of Berberine on the migratory and invasive abilities of cancer cells. . Cancer Cell & Microenvironment .2015 ;(2):e710-e710

42. 2015 Lee YC,Huang CC,Lin DY,Chang WC,Lee KH. Overexpression of centromere protein K (CENPK) in ovarian cancer is correlated with poor patient survival and associated with predictive and prognostic relevance. . PeerJ .2015 ;(3):1-16

43. 2014 Hsu TI*,Hsu CH*,Lee KH,Lin JT,Chen CS,Chang KC, Su CY, Hsiao M, Lu PJ (*Co-first author). MicroRNA-18a is elevated in prostate cancer and promotes tumorigenesis through suppressing STK4 in vitro and in vivo. . Oncogenesis .2014 ;(3):1-11

44. 2014 Chou CC,Lee KH,Lai IL,Wang D,Kulp SK,Shapiro CL, Chen CS. AMPK Reverses the Mesenchymal Phenotype of Cancer Cells by Targeting the Akt-MDM2-Foxo3a Signaling Axis. . Cancer Research .2014 ;(74):4783-4795

45. 2014 Huang CC,Bose JK,Majumder P,Lee KH,Huang JT,Huang K Jeffrey, Shen CK. Metabolism and mis-metabolism of the neuropathological signature protein TDP-43. . J Cell Sci. .2014 ;(127):3024-3038

46. 2014 Lee KH*,Lin FC*,Hsu TI,Lin JT,Guo JH,Tsai CH, Lee YC, Lee YC, Chen CL, Hsiao M, Lu PJ (*Equal contribution). MicroRNA-296-5p (miR-296-5p) functions as a tumor suppressor in prostate cancer by directly targeting Pin1. . BBA-Molecular Cell Research .2014 ;(1843):2055-2066

47. 2014 Lee KH,Lo HL,Tang WC,Hsiao HH,Yang PM. A gene expression signature-based approach reveals the mechanisms of action of the Chinese herbal medicine berberine. . Scientific Reports .2014 ;(4):6394-6394

48. 2013 Hsieh IS,Chang KC,Tsai YT,Ke JY,Lu PJ,Lee KH, Yeh SD, Hong TM, Chen YL. MicroRNA-320 Suppresses Stem Cell-Like Characteristics of Prostate Cancer Cells by Down-Regulating the Wnt/beta-catenin Signaling Pathway . Carcinogenesis .2013 ;(34):530-538

49. 2013 Liu YP,Liao WC,Ger LP,Chen JC,Hsu TI,Lee YC, Chang HT, Chen YC, Jan YH, Lee KH, Zeng YH, Hsiao M, Lu PJ. Carboxyl-Terminal Modulator Protein Positively Regulates Akt Phosphorylation and Acts as an Oncogenic Driver in Breast Cancer. . Cancer Res. .2013 ;(73):6194-6205

50. 2013 Lee YC,Que J,Chen YC,Lin JT,Liou YC,Liao PC, Liu YP, Lee KH, Lin LC, Hsiao M, Hung LY, Huang CY, Lu PJ. Pin1 Acts as a Negative Regulator of the G2/M Transition through an Interplay with the Aurora A/hBora Complex. . J Cell Sci. .2013 ;(126):4862-4872

51. 2011 Lee KH,Hsu EC,Guh JH,Yang CH,Wang D,Kulp SK, Shapiro CL, Chen CS. Targeting Energy Metabolic and Oncogenic Signaling Pathways in Triple-Negative Breast Cancer Cells by A Novel AMPK Activator. . J. Biol. Chem. .2011 ;(286):39247-39258

52. 2010 Lee CH,Wei YW,Huang YT,Lin YT,Lee YC,Lee KH, Lu PJ. CDK5 Phosphorylates eNOS at Ser-113 and Regulates NO Production. . J. Cell. Biochem. .2010 ;(110):112-117

53. 2009 Leung KW,Tsai CH,Hsiao M,Tseng CJ,Ger LP,Lee KH, Lu PJ. Pin1 Over-Expression Is Associated with Poor Differentiation and Survival in Oral Squamous Cell Carcinoma. . Oncol. Rep. .2009 ;(21):1097-1104

54. 2009 Lee KH,Goan YG,Hsiao M,Lee CH,Jian SH,Lin JT, Chen YL, Lu PJ. MicroRNA-373 (miR-373) Post-Transcriptionally Regulates Large Tumor Suppressor, Homolog 2 (LATS2) and Stimulates Proliferation in Human Esophageal Cancer. . Exp. Cell Res. .2009 ;(315):2529-2538

55. 2009 Lee KH,Chen YL,Yeh SD,Hsiao M,Lin JT,Goan YG, Lu PJ. MicroRNA-330 Acts as Tumor Suppressor and Induces Apoptosis of Prostate Cancer Cells through E2F1-Mediated Suppression of Akt Phosphorylation. . Oncogene .2009 ;(28):3360-3370

研究計畫

計畫名稱
112 靶向MIR31HG/LncHIFCAR 相關分子網絡在胰腺癌轉移和腫瘤微環境的研究-探討胰臟癌早期轉移基因-FXYD3於MIR31HG-miR-7-5p/miR-206-FXYD3訊息途徑中調控胰臟癌的轉移與酸性微環境的角色(1/3)
補助單位
國家科學及技術委員會

計畫名稱
110 探討腫瘤微環境中膠原蛋白藉由DDR1調控癌細胞PD-L1 表現進而抑制T細胞攻擊之可能性
補助單位
國家科學及技術委員會

計畫名稱
110 探討長鏈非編碼RNA-CRNDE在代謝性疾病中的角色
補助單位
奇美醫療財團法人奇美醫院

計畫名稱
110 建構基因沉默檢測平台開發計畫
補助單位
智擎生技製藥股份有限公司

計畫名稱
109 長鏈非編碼RNA-CRNDE調控代謝重整與細胞自噬之機制探討
補助單位
奇美醫療財團法人奇美醫院

計畫名稱
108 探討長非編碼RNA-CRNDE在細胞自噬作用與在化療藥物歐力普抗藥性上所扮演的角色及其分子機轉
補助單位
科技部

計畫名稱
106 探討miR-296-5p/Pin1/XPO5調控與大腸直腸癌相關之oncomiRs的表現
補助單位
阮綜合醫療社團法人阮綜合醫院

計畫名稱
106 長鏈非編碼核糖核酸CRNDE於大腸直腸癌細胞中調控基因表現機轉之探討並發展可以抑制CRNDE或其所調控訊息途徑的抑制劑
補助單位
科技部

計畫名稱
105 不同APC基因狀態大腸直腸癌患者藥物治療之抗藥性機轉研究-探討大腸直腸癌細胞中Wnt5a與Hsp90在Wnt/beta-catenin訊息傳遞途徑的角色(3/3)
補助單位

計畫名稱
104 不同APC基因狀態大腸直腸癌患者藥物治療之抗藥性機轉研究-探討大腸直腸癌細胞中Wnt5a與Hsp90在Wnt/beta-catenin訊息傳遞途徑的角色(2/3)
補助單位
科技部

計畫名稱
104 探討大腸直腸癌細胞中Wnt5a與Hsp90在Wnt/beta-catenin訊息傳遞途徑的角色((2/3)(相對補助)
補助單位
臺北醫學大學

計畫名稱
103 從染色體中心節蛋白(CENP)家族中找尋可以用來當作卵巢癌的新腫瘤標的
補助單位
衛生福利部雙和醫院(委託臺北醫學大學興建經營)

計畫名稱
103 不同APC基因狀態大腸直腸癌患者藥物治療之抗藥性機轉研究-探討大腸直腸癌細胞中Wnt5a與Hsp90在Wnt/beta-catenin訊息傳遞途徑的角色(1/3)
補助單位
科技部

計畫名稱
103 探討大腸直腸癌細胞中Wnt5a與Hsp90在Wnt/beta-catenin訊息傳遞途徑的角色(1/3)(相對補助)
補助單位
臺北醫學大學

計畫名稱
102 探討黃連素對攝護腺癌細胞對調控上皮細胞與間質細胞轉換之角色與 調控機轉之研究
補助單位
衛生福利部雙和醫院(委託臺北醫學大學興建經營)

計畫名稱
101 利用基因微陣列表現圖譜分析大腸直腸癌細胞之基因表現差異尋找具有抗癌效果之藥物及其調控機轉
補助單位
衛生福利部雙和醫院(委託臺北醫學大學興建經營)

計畫名稱
101 探討攝護腺癌細胞中AMP-活化蛋白酶(AMPK)對調控上皮細胞與間質細胞轉換之角色與調控機轉之研究
補助單位
行政院國家科學委員會

計畫名稱
101 TMU101-AE1-B19
補助單位
學校

計畫名稱
101 合併新穎AMPK活化劑與HDAC抑制劑用於癌症之研究
補助單位
臺北醫學大學