李冠德(Lee, Kuan-Der) 教授

現   職
內科學科 教授
細胞治療與再生醫學國際博士學位 主任


學 歷

美國馬里蘭大學醫學院遺傳研究所 博士
國立陽明大學醫學系 學士




2019/08/01 ~
2018/08/01 ~







1. 2020 Radiotherapy Is Associated with an Accelerated Risk of Ischemic Stroke in Oral Cavity Cancer Survivors after Primary Surgery . Cancers .2020 ;(3):616-626

2. 2019 A Novel Anti-PD-L1 Vaccine for Cancer Immunotherapy and Immunoprevention. . CancersCancers (Basel). 2019 Dec 1;11(12). .2019 ;(12):1909-1923

3. 2019 Transcatheter arterial chemoembolization improves the resectability of malignant breast phyllodes tumor with angiosarcoma component: a case report. . BMC Surg .2019 ;(1):100-107

4. 2019 Accelerated Risk of Premature Ischemic Stroke in 5-Year Survivors of Nasopharyngeal Carcinoma. . Oncologist. .2019 ;(9):e891-e897

5. 2018 A Phase II study of S-1 plus oral leucovorin in heavily treated metastatic colorectal cancer patients. . Cancer Manag Res. .2018

6. 2018 Satisfaction with pain management and impact of pain on quality of life in cancer patients. . Asia Pac J Clin Oncol. .2018 ;(1):1-8

7. 2018 Chen MC,Lee KD,Lu CH,Wang TY,Huang SH,, Chen CY. The bidirectional association among female hormone-related cancers: breast, ovary, and uterine corpus . Cancer Medicine .2018

8. 2017 Chen Chih Cheng ,You Jie Yu ,Lung Jrhau ,Huang Cih En ,Chen Yi Yang ,, Lee Kuan Der. Aberrant let7a/HMGA2 signaling activity with unique clinical phenotype in JAK2-mutated myeloproliferative neoplasms . Haematologica .2017 ;(102):509-518

9. 2017 Shen Wen Chi ,Chen Jen Shi ,Shao Yu Yun ,Lee Kuan Der ,Chiou Tzeon Jye . Impact of Undertreatment of Cancer Pain With Analgesic Drugs on Patient Outcomes: A Nationwide Survey of Outpatient Cancer Patient Care in Taiwan . Journal of Pain and Symptom Management .2017 ;(54):55-65.e1

10. 2017 Lung Jrhau ,Chen Kuan Liang ,Hung Chien Hui ,Chen Chih Cheng ,Hung Ming Szu ,, Lee Kuan-Der. In silico-based identification of human α-enolase inhibitors to block cancer cell growth metabolically . Drug Design, Development and Therapy .2017 ;(11):3281-3290

11. 2017 Wu Ching Yuan ,Yang Yao Hsu ,Lin Yin Yin ,Kuan Feng Che ,Lin Yu Shin ,, Lee Kuan-Der. Anti-cancer effect of danshen and dihydroisotanshinone I on prostate cancer: Targeting the crosstalk between macrophages and cancer cells via inhibition of the STAT3/CCL2 signaling pathway . Oncotarget .2017 ;(8):40246-40263

12. 2017 Wu Ching Yuan ,Cherng Jong Yuh ,Yang Yao Hsu ,Lin Chun Liang ,Kuan Feng Che ,, Lee Kuan Der. Danshen improves survival of patients with advanced lung cancer and targeting the relationship between macrophages and lung cancer cells . Oncotarget .2017 ;(8):90925-90947

13. 2017 Chen Chih Cheng ,Chiu Chia Chen ,Lee Kuan Der ,Hsu Chia Chen ,Chen Hong Chi . JAK2V617F influences epigenomic changes in myeloproliferative neoplasms . Biochemical and Biophysical Research Communications .2017 ;(494):470-476

14. 2017 Chen Hong Chang ,Huang Hsuan Yuan ,Chen Yao Li ,Lee Kuan Der ,Chu Yi Ru . Methylation of the Tumor Suppressor Genes HIC1 and RassF1A Clusters Independently From the Methylation of Polycomb Target Genes in Colon Cancer . Annals of Surgical Oncology .2017 ;(24):578-585

15. 2017 Zhu Andrew X. ,Baron Ari David ,Malfertheiner Peter ,Kudo Masatoshi ,Kawazoe Seiji ,, Lee Kuan Der. Ramucirumab as second-line treatment in patients with advanced hepatocellular carcinoma analysis of REACH trial results by child-pugh score . JAMA oncology .2017 ;(3):235-243

16. 2017 Lin Geng Ping ,Lee Kuan Der ,Wang Jeng Yi ,Chen Jinn Shiun ,Chiang Chun Ju . Status for clinically complete remission rectal cancer after concomitant chemo-radiotherapy in Taiwan . Asian Journal of Surgery .2017

17. 2017 Lee Kuan Der ,Wang Ting Yao ,Lu Chang Hsien ,Huang Cih En ,Chen Min Chi . The bidirectional association between oral cancer and esophageal cancer: A population-based study in Taiwan over a 28-year period . Oncotarget .2017 ;(8):44567-44578

18. 2017 Huang C. E. ,Yang Y. H. ,Chen Y. Y. ,Chang J. J. ,Chen K. J. ,, Lee Kuan Der. The impact of hepatitis B virus infection and vaccination on the development of non-Hodgkin lymphoma . Journal of Viral Hepatitis .2017 ;(24):885-894

19. 2017 Kuan Feng Che ,Lai Chia Hsuan ,Ku Hsiu Ying ,Wu Chun Feng ,Hsieh Meng Chiao ,, Lee Kuan Der. The survival impact of delayed surgery and adjuvant chemotherapy on stage II/III rectal cancer with pathological complete response after neoadjuvant chemoradiation . International Journal of Cancer .2017 ;(140):1662-1669

20. 2017 Huang Cih En ,Chen Yi Yang ,Chang Jung Jung ,Kuan Feng Che ,Lee Kuan Der . Thrombopoietic cytokines in patients with hepatitis C virus-associated immune thrombocytopenia . Hematology .2017 ;(22):54-60

21. 2016 Lung Jrhau ,Lin Yu Ching ,Hung Ming Szu ,Jiang Yuan Yuan ,Lee Kuan Der . A sensitive and high throughput TaqMan-based reverse transcription quantitative polymerase chain reaction assay efficiently discriminates ALK rearrangement from overexpression for lung cancer FFPE specimens . Lung Cancer .2016 ;(94):114-120

22. 2016 Chen Yi Yang ,Huang Cih En ,Lee Kuan Der ,Chen Chih Cheng . Clinical efficacy and safety of ruxolitinib in the management of myelofibrosis: A single institution experience in Taiwan . Hematology .2016 ;(21):3-9

23. 2016 Wang Ting Yao ,Chen Wei Ming ,Yang Lan Yan ,Chen Chao Yu ,Chou Wen Chi ,, Lee Kuan Der. Score of liver ultrasonography predicts treatment-related severe neutropenia and neutropenic fever in induction chemotherapy with docetaxel for locally advanced head and neck cancer patients with normal serum transamines . Supportive Care in Cancer .2016 ;(24):4697-4703

24. 2016 Chen Miao Fen ,Chen Ping Tsung ,Chen Wen Cheng ,Lu Ming Shian ,Lin Paul Yang ,, Lee Kuan Der. The role of PD-L1 in the radiation response and prognosis for esophageal squamous cell carcinoma related to IL-6 and T-cell immunosuppression . Oncotarget .2016 ;(7):7913-7924

25. 2015 Chen J. S. ,Hsu C. ,Chiang N. J. ,Tsai C. S. ,Tsou H. H. ,, Lee Kuan Der. A KRAS mutation status-stratified randomized phase II trial of gemcitabine and oxaliplatin alone or in combination with cetuximab in advanced biliary tract cancer . Annals of Oncology .2015 ;(26):943-949

26. 2015 Chen Chih Cheng ,Lee Kuan Der ,Pai Mei Yu ,Chu Pei Yi ,Hsu Chia Chen . Changes in DNA methylation are associated with the development of drug resistance in cervical cancer cells . Cancer Cell International .2015 ;(15)

27. 2015 Hsieh Jason Chia Hsun ,Hsu Cheng Lung ,Ng Shu Hang ,Wang Cheng Hsu ,Lee Kuan Der . Gemcitabine plus cisplatin for patients with recurrent or metastatic nasopharyngeal carcinoma in Taiwan: A multicenter prospective Phase II trial . Japanese Journal of Clinical Oncology .2015 ;(45):819-827

28. 2015 Wang Ting Yao ,Lee Kuan Der ,Chen Ping Tsung ,Chen Min Chi ,Chen Yi Yang . Incidence and risk factors for central venous access port-related infection in Chinese cancer patients . Journal of the Formosan Medical Association .2015 ;(114):1055-1060

29. 2015 Lee Kuan Der ,Chen Chao Yu ,Huang Huei Jean ,Wang Ting Yao ,Teng David . Increased risk of second primary malignancies following uterine cancer: A population-based study in Taiwan over a 30-year period . BMC Cancer .2015 ;(15)

30. 2015 Kuan Feng Che ,Kuo Liang Tseng ,Chen Min Chi ,Yang Cheng Ta ,Shi Chung Sheng ,, Lee Kuan Der. Overall survival benefits of first-line EGFR tyrosine kinase inhibitors in EGFR-mutated non-small-cell lung cancers: A systematic review and meta-analysis . British Journal of Cancer .2015 ;(113):1519-1528

31. 2015 Rau Kun Ming ,Lin Yung Chang ,Chen Yen Yang ,Chen Jen Shi ,Lee Kuan Der . Pegylated liposomal doxorubicin (Lipo-Dox®) combined with cyclophosphamide and 5-fluorouracil is effective and safe as salvage chemotherapy in taxane-treated metastatic breast cancer: An open-label, multi-center, non-comparative phase II study . BMC Cancer .2015 ;(15)

32. 2015 Chen Yi Yang ,Huang Cih En ,Liang Fu Wen ,Lu Chang Hsien ,Chen Pin Tsung ,, Lee Kuan Der. Prognostic impact of hepatitis C virus infection in patients with diffuse large B-cell lymphoma treated with immunochemotherapy in the context of a novel prognostic index . Cancer Epidemiology .2015 ;(39):382-387

33. 2015 Huang Cih En ,Chen Yi Yang ,Lu Chang Hsien ,Chen Pin Tsung ,Lee Kuan Der . Validation of an enhanced International Prognostic Index (NCCN-IPI) in an Asian cohort of patients with diffuse large B cell lymphoma . Annals of Hematology .2015 ;(94):1063-1065

34. 2014 Su Ching Ching ,Lee Kuan Der ,Yeh Chung Hung ,Kao Ching Chiu ,Lin Chia Chin . Measurement of physical activity in cancer survivors: A validity study . Journal of Cancer Survivorship .2014 ;(8):205-212

35. 2013 Lee Kuan Der ,Chen Hong Hwa ,Wang Hwei Ming ,Tsao Chao Jung ,Hsu Tzu Chi . An open-label safety study of first-line bevacizumab in combination with standard chemotherapy in Chinese patients with metastatic colorectal cancer treated in an expanded access program in Taiwan . Oncology .2013 ;(84):299-304

36. 2013 Lu Chang Hsien ,Lee Kuan Der ,Chen Ping Tsung ,Chen Chih Cheng ,Kuan Feng Che . Second primary malignancies following thyroid cancer: A population-based study in Taiwan . European Journal of Endocrinology .2013 ;(169):577-585


106 新聘教師研究補助