洪君琳(Horng, Jiun-Lin) 教授

Email
jlhorng@tmu.edu.tw
現   職
斑馬魚模式核心服務實驗室 主任
解剖學暨細胞生物學科 主任
解剖學暨細胞生物學科 教授

學經歷

學 歷

畢業學校與學位[修業時間]
國防醫學院生命科學所 博士
2002/09~2007/11
陽明大學生理所 碩士
1999/09~2001/06
台灣大學動物系 學士
1995/09~1999/06

本校學術經歷

任職單位與職稱[起迄時間]
解剖學暨細胞生物學科教授
2020/08/01~
解剖學暨細胞生物學科副教授
2015/08/01~2020/07/31
解剖學暨細胞生物學科助理教授
2014/08/01~2015/07/31
解剖學科助理教授
2010/06/08~2014/07/31

本校兼職教學行政經歷

服務單位與職稱[起迄時間]
解剖學暨細胞生物學科主任
2019/08/01 ~
斑馬魚模式核心服務實驗室主任
2016/11/01 ~

其它經歷

任職單位與職稱[起迄時間]
中央研究院博士後研究
2007/11/12~2010/06/07

專長與研究領域

學門領域
動物學
生理
解剖
學術專長
電子顯微鏡學
電子顯微鏡學
毒理學
毒理學
動物行為學
動物行為學
電生理學
電生理學
漁業
漁業
實驗動物學
實驗動物學
實驗動物繁殖
實驗動物繁殖

論文著作

清冊下載


1. 2020 Su BC,Li CC,Horng JL,Chen JY. Calcium-Dependent Calpain Activation-Mediated Mitochondrial Dysfunction and Oxidative Stress Are Required for Cytotoxicity of Epinecidin-1 in Human Synovial Sarcoma SW982 Cells . Int J Mol Sci . .2020

2. 2020 Liu ST,Chou MY,Wu LC,Horng JL,Lin LY. Transient Receptor Potential Vanilloid 4 Modulates Ion Balance Through the Isotocin Pathway in Zebrafish ( Danio rerio) . Am J Physiol Regul Integr Comp Physiol .2020 ;(318):R751-R759

3. 2020 Sinusaitea L,Popova A,Antuzevicsc A,Mazeikad K,Baltrunasd D,Yange JC, Horng JL, Shig S, Sekinog T, Ishikawah K, Kareivaa A, Zarkova A. Fe and Zn co-substituted beta-tricalcium phosphate (β-TCP): Synthesis, structural, magnetic, mechanical and biological properties . Materials Science & Engineering C .2020

4. 2020 Chou CM,Mi FL,Horng JL,Lin LY,Tsai ML,Liu CL, Lu ⁠KY, Chu ⁠CY, Chen ⁠YT, Lee ⁠YLA, Cheng CH. Characterization and toxicology evaluation of low molecular weight chitosan on zebrafish . Carbohydrate Polymers .2020

5. 2020 Lin LY,Zheng JA,Huang SC,Hung GY,Horng JL. Ammonia exposure impairs lateral-line hair cells and mechanotransduction in zebrafish embryos. . Chemosphere .2020

6. 2020 Lee CY, Horng JL ,Liu ST,Lin LY. Exposure to copper nanoparticles impairs ion uptake, and acid and ammonia excretion by ionocytes in zebrafish embryos. . Chemosphere .2020

7. 2020 Yen HJ,Lin JR,Yeh YH,Horng JL,Lin LY. Exposure to colistin impairs skin keratinocytes and lateral-line hair cells in zebrafish embryos. . Chemosphere .2020

8. 2020 Fu CW,Horng JL,Tong SK,Cherng BW,Liao BK,Lin LY, Chou MY. Exposure to silver impairs learning and social behaviors in adult zebrafish. . Journal of hazardous materials. .2020

9. 2020 Hung GY,Chen PY,Horng JL,Lin LY. Vincristine exposure impairs skin keratinocytes, ionocytes, and lateral-line hair cells in developing zebrafish embryos. . Aquatic Toxicology. .2020

10. 2019 Hung GY,Wu CL,Chou YL,Chien CT,Horng JL, Lin LY. Cisplatin exposure impairs ionocytes and hair cells in the skin of zebrafish embryos. . Aquat Toxicol .2019 ;(209):168-177

11. 2019 Hung GY, Yu TY, Yen HJ, Yang CF, Lin LY,Horng JL. Systemic Epstein-Barr Virus-positive T-Cell Lymphoma of Childhood Presentation With Hemophagocytosis. . J Pediatr Hematol Oncol .2019 ;(41):319

12. 2019 Hung GY,Horng JL, Chen PC,Lin LY,Chen JY,Chuang PH, Chao TC, Yen CC. Incidence of soft tissue sarcoma in Taiwan: A nationwide population-based study (2007-2013). . Cancer Epidemiol. .2019 ;(60):185-192

13. 2019 Lee CY, Horng JL,Chen PY,Lin LY. Silver nanoparticle exposure impairs ion regulation in zebrafish embryos. . Aquat Toxicol .2019 ;(214):105263-105263

14. 2019 Yen HJ,Horng JL,Yu CH,Fang CY,Yeh YH,Lin LY.. Toxic effects of silver and copper nanoparticles on lateral-line hair cells of zebrafish embryos. . Aquat Toxicol .2019 ;(215):105273-105273

15. 2019 Lin LY,Hung GY,Yeh YH,Chen SW,Horng JL. Acidified water impairs the lateral line system of zebrafish embryos . Aquatic Toxicology .2019 ;(217):105351-105351

16. 2018 Hung GY,Lin LY,Yu TY,Lee CY,Yen HJ,Horng JL. Hepatoblastoma Incidence in Taiwan: A Population-Based Study . Journal of the Chinese Medical Association .2018 ;(81):541-547

17. 2018 Lin LY,Yeh YH,Hung GY,Lin CH,Hwang PP,Horng JL. Role of Calcium-Sensing Receptor in Mechanotransducer Channel Mediated Ca2+ Influx in Hair Cells of Zebrafish Larvae . frontiers in physiology .2018 ;(9):649-649

18. 2018 Hung Giun Yi ,Lee Chih Ying ,Yen Hsiu Ju ,Lin Li Yih ,Horng Jiun Lin . Incidence of immune thrombocytopenia in Taiwan: a nationwide population-based study . Transfusion .2018 ;(58):2712-2719

19. 2017 Horng JL,Yu LL, Liu ST,Chen PY,Lin LY. Potassium Regulation in Medaka (Oryzias latipes) Larvae Acclimated to Fresh Water: Passive Uptake and Active Secretion by the Skin Cells. . Sci Rep. .2017 ;(7):16215-1621

20. 2016 Hung GY,Chen CC,Horng JL,Lin LY. Cancer in adolescents: Incidences and trends during 1995-2009 in Taiwan. . Cancer Lett .2016 ;(372):110-117

21. 2016 Liu ST,Horng JL,Chen PY,Hwang PP,Lin LY. Salt secretion is linked to acid-base regulation of ionocytes in seawater-acclimated medaka: new insights into the salt-secreting mechanism. . Sci Rep .2016 ;(6):31433

22. 2015 Lin YH,Hung GY,Wu LC,Chen SW,Lin LY,Horng JL. Anion exchanger 1b in stereocilia is required for the functioning of mechanotransducer channels in lateral-line hair cells of zebrafish. . PLOS ONE .2015 ;(10):e01170-e0117041

23. 2015 Wu HJ,Fong TH,Chen SL,Wei JC,Wang IJ,Wen CC, Chang CY, Chen XG, Chen WY, Chen HM, Horng JL, Wang YH, Chen YH.. Perturbation of cytosolic calcium by 2-aminoethoxydiphenyl borate and caffeine affects zebrafish myofibril alignment. . J Appl Toxicol. .2015 ;(35):287-294

24. 2015 Hung GY,Horng JL,Yen HJ,Lee CY. Infant Cancer in Taiwan: Incidence and Trends (1995-2009). . PLoS One. .2015 ;(10):130444

25. 2015 Hung GY,Horng JL,Yen HJ,Lee CY,Lee YS. Geographic Variation in Cancer Incidence among Children and Adolescents in Taiwan (1995-2009). . PLoS One. .2015 ;(10):133051

26. 2015 Hung GY,Horng JL,Yen HJ,Lee CY. Pre-pubertal and adolescent germ cell neoplasms in Taiwan: time trends and geographic variation. . Andrology .2015 ;(3):895-901

27. 2015 Horng JL,Chao PL,Chen PY,Shih TH,Lin LY. Aquaporin 1 Is Involved in Acid Secretion by Ionocytes of Zebrafish Embryos through Facilitating CO2 Transport. . PLoS One .2015 ;(10):e0136440-e0136440

28. 2015 Hung GY,Yen CC,Horng JL,Liu CY,Chen WM,Chen TH, Liu CL. Incidences of Primary Soft Tissue Sarcoma Diagnosed on Extremities and Trunk Wall: A Population-Based Study in Taiwan. . Medicine .2015 ;(94):e1696

29. 2015 Hung GY,Horng JL,Yen HJ,Lee CY,Lin LY. Changing incidence patterns of hepatocellular carcinoma among age groups in Taiwan . J Hepatol .2015 ;(63):1390-1396

30. 2014 Hsu HH,Lin LY,Tseng YC,Horng JL,Hwang PP. A new model for fish ion regulation: identification of ionocytes in freshwater- and seawater-acclimated medaka (Oryzias latipes) . Cell Tissue Res .2014 ;(357):225-43

31. 2014 Hung GY,Horng JL,Yen HJ,Yen CC,Chen WM,Chen PCH, Wu HTH, Chiou HJ. Incidence Patterns of Primary Bone Cancer in Taiwan (2003–2010): A Population-Based Study . Ann Surg Oncol .2014 ;(21):2490-8

32. 2014 Hung GY,Horng JL,Lee YS,Yen HJ,Chen CC,Lee CY. Cancer incidence patterns among children and adolescents in Taiwan from 1995 to 2009: A population-based study. . Cancer- Am Cancer Soc .2014

33. 2013 Shih TH,Horng JL,Lai YT,Lin LY. Rhcg1 and Rhbg mediate ammonia excretion by ionocytes and keratinocytes in the skin of zebrafish larvae: H+-ATPase-linked active ammonia excretion by ionocytes. . Am J Physiol Regul Integr Comp Physiol. .2013 ;(304):R1130-R1138

34. 2013 Liu ST,Tsung L,Horng JL,Lin LY. Proton-facilitated ammonia excretion by ionocytes of medaka (Oryzias latipes) acclimated to seawater. . Am J Physiol Regul Integr Comp Physiol .2013 ;(305):R242-R251

35. 2013 Lin LY,Pang W,Chuang WM,Hung GY,Lin YH,Horng JL. Extracellular Ca2+ and Mg2+ modulate aminoglycoside blockade of mechanotransducer channel-mediated Ca2+ entry in zebrafish hair cells: an in vivo study with the SIET . Am J Physiol Cell Physiol. .2013 ;(305):C1060-C1068

36. 2012 Tin-Han, Shih,Jiun-Lin, Horng,Sian-Tai, Liu,Pung-Pung, Hwang,Li-Yih, Lin. Rhcg1 and NHE3b are involved in ammonium-dependent sodium uptake by zebrafish larvae acclimated to low-sodium water . Am J Physiol Regul Integr Comp Physiol .2012 ;(302):R84-93

37. 2012 Chia-Cheng, Lin,Li-Yih, Lin,Hao-Hsuan, Hsu,Violette Thermes,Patrick Prunet,Jiun-Lin Horng, Pung-Pung Hwang. Acid secretion by mitochondrion-rich cells of medaka (Oryzias latipes) acclimated to acidic freshwater. . Am J Physiol Regul Integr Comp Physiol .2012 ;(302):R283-R291

38. 2011 Shen WP,Horng JL,lin ly. Functional Plasticity of Mitochondrion-Rich Cells in the Skin of Euryhaline Medaka Larvae (Oryzias latipes) Subjected to Salinity Changes . Am J Physiol (Regul Integr Comp Physiol) .2011 ;(300):r858-68

39. 2010 Lee YC,Yan JJ,Cruz S,Horng JL,Hwang PP. Anion exchanger 1b, but not sodium-bicarbonate cotransporter 1b, plays a role in transport functions of zebrafish H+-ATPase-rich cells . Am J Physiol (Cell Physiol) .2010

40. 2010 Wu SC,Horng JL,Hwang PP,Wen ZH,Lin CS,Lin LY. Ammonium-Dependent Sodium Uptake in Mitochondrion-Rich Cells of Medaka (Oryzias latipes) Larvae . Am J Physiol (Cell Physiol) .2010 ;(298):c237-c250

41. 2009 Horng JL,Hwang PP,Shih TH,Wu SC,Lin LY. Chloride Transport in Mitochondrion-Rich Cells of Euryhaline Tilapia (Oreochromis mossambicus) Larvae . Am J Physiol (Cell Physiol) .2009 ;(297):c845-c854

42. 2009 Horng JL,Lin LY,Hwang PP. Functional regulation of H+-ATPase-rich cells in zebrafish embryos acclimated to an acidic environment . Am J Physiol (Cell Physiol) .2009 ;(296):c682-c692

43. 2009 Chang WJ,Horng JL,Yan JJ,Hsiao CD,Hwang PP. The transcription factor, glial cell missing 2, is involved in differentiation and functional regulation of H+-ATPase rich cells in zebrafish (Danio rerio) . Am J Physiol (Regul Integr Comp Physiol) .2009 ;(296):r1192-r1201

44. 2008 Shih TH,Horng JL,Hwang PP,Lin LY. Ammonia secretion in skin of zebrafish larvae (Danio rerio) . Am J Physiol (Cell Physiol) .2008 ;(295):c1625-c1632

45. 2008 Horng JL,Lin LY. Expression of the Na-K-2Cl Cotransporter in Branchial Mitochondrion-Rich Cells of Tilapia (Oreochromis mossambicus) Responding to Ambient Chloride Levels . Zoological Studies .2008 ;(47):733-740

46. 2008 Lin TY,Liao BK,Horng JL,Yan JJ,Hsiao CD,Hwang PP. Carbonic anhydrase 2-like a and 15a are involved in acid-base regulation and Na+ uptake in zebrafish H+-ATPase-rich cells . Am J Physiol (Cell Physiol) .2008 ;(294):c1250-c1260

47. 2007 Horng JL,Lin LY,Huang CJ,Katoh F,Kaneko T,Hwang PP. Knockdown of V-ATPase subunit A (atp6v1a) impairs acid secretion and ion balance in zebrafish (Danio rerio). . Am J Physiol (Regul Integr Comp Physiol) .2007 ;(292):r2068-r2076

48. 2006 Lin LY,Horng JL,Kunkel JG,Hwang PP. Proton pump-rich cell secretes acid in skin of zebrafish larvae . Am J Physiol (Cell Physiol) .2006 ;(290):c371-c378

49. 2005 Shiao JC,Lin LY,Horng JL,Hwang PP,Kaneko T. How can teleostean inner ear hair cells maintain the proper association with the accreting otolith? . J Comp Neurol. .2005 ;(488):331-341


1. 2018 Horng JL, ,Lin LY.. Using Scanning Ion-Electrode Technique (SIET) for functional study of mechanotransducer channel in zebrafish neuromast hair cells. . In 13th International Congress on Biology of Fish. Calgary, Canada. .2018

2. 2017 Horng JL, ,Yeh YH, ,Lin LY.. Scanning Ion-Electrode Technique (SIET) for functionally assaying mechanotransducer channel in hair cells of zebrafish. . 10th European Zebrafish Meeting.Budapest, Hungary .2017

3. 2015 Horng JL, ,Yeh YH,,Lin LY. Plasma membrane Ca2+ ATPase in stereocilia is required for the functioning of mechanotransducer channels in lateral-line hair cells of zebrafish. . 9th international congress of comparative physiology and biochemistry. Krakow. Poland. .2015

4. 2014 Horng JL,Lin LY. Effect of acidic environment on mechanotransducer channel-mediated Ca2+ entry in zebrafish neuromast hair cells . 11th international congress on the biology of fish. Edinburgh. UK. Aug. 3-7. Poster presentation. .2014

5. 2013 Horng jl,Lin LY. Extracellular Ca2+ and Mg2+ modulate aminoglycoside blockade of mechanotransducer channel-mediated Ca2+ entry in zebrafish hair cells: an in vivo study with SIET . In 8th European zebrafish meeting. Barcelona. Spain. Jul.9-13. Poster. .2013

6. 2012 Horng JL,Lin LY. Properties of the mechanotransduction channel in lateral line hair cells of zebrafish larvae. . In 10th international congress on the biology of fish. Madison. USA. Jul. 15-19. Oral presentation. .2012

7. 2010 Horng JL,Lin LY,Hwang PP. Concanavalin A-Mediated Endocytosis in Zebrafish H+-ATPase-Rich Cell is Regulated by H+-ATPase and Actin . 9th international congress on the biology of fish. Barcelona, Spain. Jul.5-9. Oral presentation. .2010

研究計畫

計畫名稱
109 環境酸化對魚類側線感覺毛細胞的傷害機制
補助單位
科技部

計畫名稱
108 k-kit在生物醫學電鏡樣本製備的應用與技術開發研究計畫
補助單位
閎康科技股份有限公司

計畫名稱
107 環境pH值對於毛細胞機械性感測傳導機制的影響--鈣離子感應接受器所扮演的角色(3/3)
補助單位
科技部

計畫名稱
106 環境pH值對於毛細胞機械性感測傳導機制的影響--鈣離子感應接受器所扮演的角色(2/3)
補助單位
科技部

計畫名稱
105 新型包埋劑在電顯的應用與技術開發
補助單位
益新儀器有限公司

計畫名稱
105 環境pH值對於毛細胞機械性感測傳導機制的影響--鈣離子感應接受器所扮演的角色(1/3)
補助單位
科技部

計畫名稱
105 環境pH值對於毛細胞機械性感測傳導機制的影響--鈣離子感應接受器所扮演的角色(1/3)
補助單位

計畫名稱
105 環境pH值對於毛細胞機械性感測傳導機制的影響--鈣離子感應接受器所扮演的角色-林家豪
補助單位
科技部

計畫名稱
104 鈣離子感應接受器在毛細胞機械性感測傳導機制中所扮演的角色
補助單位
科技部

計畫名稱
103 毛細胞機械性感測傳導機制之研究
補助單位
科技部

計畫名稱
101 以改良式放大器偵測順鉑對於毛細胞機械性感測傳導通道功能的影響
補助單位
臺灣科技大學

計畫名稱
100 斑馬魚毛細胞機械性感測傳導通道之研究
補助單位
行政院國家科學委員會