劉俊仁(Liu, Jun-Jen) 副教授

Email
jjliu_96@tmu.edu.tw
現   職
醫學檢驗暨生物技術學系 副教授

學經歷

學 歷

畢業學校與學位[修業時間]
國立臺灣大學生物化學暨分子生物學研究所 博士
1995/09~2003/06
國立陽明大學微生物及免疫學研究所 碩士
1991/09~1993/06
私立淡江大學化學系 學士
1987/09~1991/06

本校學術經歷

任職單位與職稱[起迄時間]
醫學檢驗暨生物技術學系副教授
2016/02/01~
醫學檢驗暨生物技術學系助理教授
2011/02/01~2016/01/31
醫學檢驗暨生物技術學系(舊)助理教授
2007/08/20~2011/01/31

本校兼職教學行政經歷

服務單位與職稱[起迄時間]
食品安全學系副教授
2017/12/01 ~
生技醫療產業研發博士學位學程副教授
2017/06/01 ~
食品安全碩士學位學程副教授
2016/08/01 ~
醫學生物科技博士學位學程籌備處助理教授
2015/02/01 ~
共同儀器中心主任
2011/05/01 ~ 2012/10/31
研究推動中心主任
2010/02/01 ~ 2011/04/30
醫學科學研究所助理教授
2007/08/20 ~

其它經歷

任職單位與職稱[起迄時間]
台灣微脂體股份有限公司副理
2006/01~2007/08
台灣微脂體股份有限公司主任
2002/12~2006/01

專長與研究領域

學門領域
微脂體藥物包覆劑型及抗癌藥物研究(Liposomes formulation and Anticancer Study)
藥物發展相關動物模式實驗 (Animal models for Drug Development)
分子生物及細胞生物學相關研究 (Molecular & Cell Biology)
血管新生相關疾病研究 (Angiogenesis Related Disease)-
中草藥與免疫調控相關研究 (Immunomodulation of herbal medicine)
學術專長

論文著作

清冊下載


1. 2019 Effects of dietary exposure to chlorpyrifos on immune cell populations and inflammatory responses in mice with dextran sulfate sodium-induced colitis . Food Chem Toxicol .2019 ;(131):1105

2. 2018 Expression and Regulation of Thymic Stromal Lymphopoietin and Thymic Stromal Lymphopoietin Receptor Heterocomplex in the Innate-Adaptive Immunity of Pediatric Asthma. . Int J Mol Sci .2018 ;(19)

3. 2018 Su CY, ,Liu JJ,, Ho YS, ,Huang YY, ,Chang VH, ,Liu DZ, Chen LC, Ho HO, Sheu MT.. Development and characterization of docetaxel-loaded lecithin-stabilized micellar drug delivery system (LsbMDDs) for improving the therapeutic efficacy and reducing systemic toxicity. . Eur J Pharm Biopharm. .2018 ;(123):9-19

4. 2018 Lin LC,, Chen CF, ,Ho CT, , Liu JJ, ,Liu TZ,, Chern CL.. γ-Glutamylcysteine synthetase (γ-GCS) as a target for overcoming chemo- and radio-resistance of human hepatocellular carcinoma cells. . Life Sci .2018 ;(198):25-31

5. 2018 Chuang LT,Tsai TH, Lien TJ,Huang WC, Liu JJ, Chang H, Chang ML, Tsai PJ.. Ethanolic Extract of Origanum vulgare Suppresses Propionibacterium acnes-Induced Inflammatory Responses in Human Monocyte and Mouse Ear Edema Models. . molecules .2018 ;(23):1987

6. 2018 Ciou Jheng Ming,Wang Bo Cheng,Su Chie Shaan,Liu Jun Jen,Sheu Ming Thau. Measurement of solid solubility of warfarin in supercritical carbon dioxide and recrystallization study using supercritical antisolvent process . Advanced Powder Technology .2018 ;(29):479-487

7. 2017 Kuo Peng Hsuan,Zhang Bo Cong,Su Chie Shaan,Liu Jun Jen,Sheu Ming Thau. Application of two-level factorial design to investigate the effect of process parameters on the sonocrystallization of sulfathiazole . Journal of Crystal Growth .2017 ;(471):8-14

8. 2017 Chang TS, Chen CL, Wu YC,Liu JJ , Kuo YC, Lee KF, Lin SY, Lin SE, Tung SY, Kuo LM, Tsai YH, Huang YH.. Inflammation Promotes Expression of Stemness-Related Properties in HBV-Related Hepatocellular Carcinoma. . PLoS One .2017 ;(12):171176

9. 2017 Lai KG,, Chen CF, ,Ho CT, ,Liu JJ,, Liu TZ, ,Chern CL.. Novel roles of folic acid as redox regulator: Modulation of reactive oxygen species sinker protein expression and maintenance of mitochondrial redox homeostasis on hepatocellular carcinoma. . Tumour Biol. .2017 ;(39)

10. 2017 Chang YF,Hou YC,Pai MH,Yeh, SL,Liu JJ. Effects of n-3 polyunsaturated fatty acids on the homeostasis of CD4+ T cells and lung injury in mice with polymicrobial sepsis. . Journal of Parenteral and Enteral Nutrition .2017 ;(41):805-814

11. 2016 Pai MH,Liu JJ,Hou YC,Yeh CL. A Soybean and Fish Oil Mixture With Different ω-6/ω-3 PUFA Ratios Modulates DSS-Induced Changes in Small Intestinal Intraepithelial γδT-Lymphocyte Expression in Mice. . Journal of Parenteral and Enteral Nutrition .2016 ;(40):383-391

12. 2016 Chiang CS, ,Shen YS, ,Liu JJ, ,Shyu WC, ,Chen SY. Synergistic Combination of Multistage Magnetic Guidance and Optimized Ligand Density in Targeting a Nanoplatform for Enhanced Cancer Therapy. . Adv Healthc Mater. .2016 ;(5):2131-41

13. 2015 Ho CT, Chang YJ,, Yang LX,, Wei PL, ,Liu TZ,, Liu JJ.. A Novel Microtubule-Disrupting Agent Induces Endoplasmic Reticular Stress-Mediated Cell Death in Human Hepatocellular Carcinoma Cells. . PLoS One. .2015 ;(10)::e0136340

14. 2015 Fang Kuan Min,Liu Jun Jen,Li Chun Chun,Cheng Chih Chi,Hsieh Yun Ti,Chai Kit Man,Lien Yu An,Tzeng Shun Fen. Colchicine derivative as a potential anti-glioma compound . Journal of Neuro-Oncology .2015 ;(124):403-412

15. 2015 Jhan HJ,,Liu JJ,Chen YJ,Liu DZ,Sheu MT,Ho HO. Novel injectable thermosensitive hydrogels for delivering hyaluronic acid-doxorubicin nanocomplexes to locally treat tumors. . Nanomedicine .2015 ;(10):1263-1274

16. 2015 Jun-Jen Liu,Hsueh-Hsia Wu,Tzu-Ho Chen,Wan Leung,Yu-Chih Liang. 15,16-Dihydrotanshinone I from the functional food Salvia miltiorrhiza exhibits anticancer activity in human leukemia cells: in vitro and in vivo studies. . Int. J. Mol. Sci. .2015 ;(16):19387-19400

17. 2015 Hung-Hsin Chen,Chie-Shaan Su,Jun-Jen Liu,Ming-Thau Sheu. Solid-state property modification and dissolution rate enhancement of tolfenamic acid by supercritical antisolvent process . The Journal of Supercritical Fluids .2015 ;(101):17-23

18. 2015 Chun-Te Ho,Hung-Sheng Shang,Jin-Biou Chang,Jun-Jen Liu,Tsan-Zon Liu. Folate deficiency-triggered redox pathways confer drug resistance in hepatocellular carcinomaV . oncotarget .2015 ;(6):26104-26118

19. 2014 Pai MH,Liu JJ,Yeh SL,,Chen WJ,Yeh CL. Glutamine modulates acute DSS-induced changes to small-intestinal intraepithelial γδT lymphocyte expression in mice . Br J Nutr .2014

20. 2014 Hsiung YC,Liu JJ,Hou YC,Yeh CL,Yeh SL. Effects of dietary glutamine on the homeostasis of CD4+ T cells in mice with dextran sulfate sodium-induced acute colitis . Plos One .2014

21. 2013 Jun-Jen Liu,Sami Nazzal,Tzu-Shan Chang,Tsuimin Tsai. Preparation and characterization of cosmeceutical liposomes loaded with avobenzone and arbutin . J. Cosmet. Sci .2013 ;(64):1-9

22. 2013 Wei PL,Tu CC,Chen CH,Ho YS,Wu CT,Su HY,Chen WY, Liu JJ, Chang YJ.. Shikonin Suppresses the Migratory Ability of Hepatocellular Carcinoma Cells. . J Agric Food Chem. .2013 ;(61):8191-8197

23. 2013 Fang KM,Lin TC,Chan TC,Ma SZ,Tzou BC,Chang WR, Liu JJ, Chiou SH, Yang CS, Tzeng SF. Enhanced cell growth and tumorigenicity of rat glioma cells by stable expression of human CD133 through multiple molecular actions . Glia .2013 ;(61):1402-1417

24. 2013 Hou YC,Liu JJ,Pai MH,Tsou SS,Yeh SL.. Alanyl-glutamine administration suppresses Th17 and reduces inflammatory reaction in dextran sulfate sodium-induced acute colitis. . Int Immunopharmacol .2013 ;(17):1-8

25. 2013 Hou YC,Pai MH,Liu JJ,Yeh SL. Alanyl-glutamine resolves lipopolysaccharide-induced lung injury in mice by modulating the polarization of regulatory T cells and T helper 17 cells . J Nutr Biochem .2013 ;(24):1555-1563

26. 2012 Ying-Chen Chen,Hsiu-O Ho,Der-Zen Liu,Jun-jen Liu,Tsung-Wei Chang,Ming-Thau Sheu. Development of terbinafine solid lipid nanoparticles as a topical delivery system. . International journal of nanomedicine .2012 ;(7):4409-4418

27. 2012 Chin-Sheng Hung,Hui-Hsiung Liu,Jun-Jen Liu,Chi-Tai Yeh,Tung-Cheng Chang,Chih-Hsiung Wu, Yuan-Soon Ho, Po-Li Wei, and Yu-Jia Chang. MicroRNA-200a and -200b Mediated Hepatocellular Carcinoma Cell Migration Through the Epithelial to Mesenchymal Transition Markers . Annals of surgical oncology .2012

28. 2012 Pei-Hsuan Tsai,Chui-Li Yeh,Jun-Jen Liu,Wan-Chun Chiu,,Sung-Ling Yeh. Effects of dietary glutamine on inflammatory mediator gene expressions in rats with streptozotocin-induced diabetes . Nutrition .2012 ;(28):288

29. 2012 Ya-Mei Hu,Chiu-Li Yeh,Man-Hui Pai,Cheng-Chung Li,Jun-Jen Liu,Sung-Ling Yeh. Effects of Arginine Supplementation on Exogenous Advanced Glycation End Product-induced Renal Inflammatory Mediator Expression in Rats . Journal of Experimental & Clinical Medicine .2012 ;(4):24-29

30. 2012 Meng LM,Pai MH,Liu JJ,Yeh SL. Polysaccharides from extracts of Antrodia camphorata mycelia and fruiting bodies modulate inflammatory mediator expression in mice with polymicrobial sepsis. . nutrition .2012

31. 2012 Yeh CL,Hu YM,Liu JJ,Chen WJ,Yeh SL. Effects of supplemental dietary arginine on the exogenous advanced glycosylation end product (AGE)-induced IL-23/IL-17 immune response in rats. . nutrition .2012

32. 2011 Pei-Hsuan Tsai,Jun-Jen Liu,Chui-Li Yeh,Wan-Chun Chiu,Sung-Ling Yeh. Effects of glutamine supplementation on oxidative stress-related gene expression and antioxidant properties in rats with streptozotocin-induced type 2 diabetes . Br J Nutr .2011

33. 2011 Kuan-Hsun Huang,Man-Hui Pai,Ching-Hsiang Wu,Jun-Jen Liu,Sung-Ling Yeh. Supplemental dietary arginine reduces renal RAGE expression and oxidative damage in rats with streptozotocin-induced type 2 diabetes . Clinical Nutrition and Metabolism .2011 ;(30):124-129

34. 2011 Huang MT,Wei PL,Liu JJ,Liu DZ,Huey-Chun H,An J, Wu CC, Wu CH, Ho YS, Yang YY, Chang YJ. Knockdown of thrombomodulin enhances HCC cell migration through increase of ZEB1 and decrease of E-cadherin gene expression. . Ann Surg Oncol. .2011 ;(17):3379-3385

35. 2011 Tsai PH,Liu JJ,Chiu WC,Pai MH,Yeh SL. Effects of dietary glutamine on adhesion molecule expression and oxidative stress in mice with streptozotocin-induced type 1 diabetes. . Clin Nutr. .2011 ;(30):124-129

36. 2011 Lien YC,Wang W,Kuo LJ,Liu JJ,Wei PL,Yuan-Soon H, Wen-Chien Ting, Yu-Jia Chang. Nicotine Promotes Cell Migration Through Alpha7 Nicotinic Acetylcholine Receptor in Gastric Cancer Cells . Ann Surg Oncol .2011

37. 2009 Tsai PH,Liu JJ,Chou SY,Chang YG,Yeh SL. Effect of lower-extremity bypass surgery on inflammatory reaction and endothelial dysfunction in type 2 diabetic patients . mediator of inflammation .2009

38. 2004 Liu,J.J,Huang,T.S,Hsu,M.L,Chen,C.C,Lin,W.S.,Lu,F.J. and Chang,W.H.. Antitumor effects of the partially purified polysaccharides from Antrodia camphorata and the mechanism of its action . Toxicol.Appl.Pharmacol. .2004 ;(201):186-193

39. 2003 Liu,J.J.,Huang,T.S.,Cheng,W.F.,Lu,F.J.. Baicalein and baicalin are potent inhibitors of angiogenesis: Inhibition of endothelial cell proliferation, migration and differentiation . Int.J.Cancer .2003 ;(106):559-563

40. 2003 Liao, H.J.,Chen, Y.J,Liu, J.J,Hsu, M.L.,Shieh, H.J,Shieh, C.J., Shiao, M.S.. Inhibitory effect of caffeic acid phenethyl ester on angiogenesis, tumor invasion, and metastasis . J Agric Food Chem .2003 ;(51):7907-7912

41. 2002 Liu,J.J.,Hong,R.L,Cheng,W.F,Hong,K.,Chang,F.H,Tseng,Y.L. Simple and efficient liposomal encapsulation of topotecan by ammonium sulfate gradient: stability, pharmacokinetic and therapeutic evaluation . Anticancer Drugs .2002 ;(13):709-717

42. 2002 Tseng,Y.L.,Liu,J.J.,Hong,R.L. Translocation of liposomes into cancer cells by cell-penetrating peptides penetratin and tat: a kinetic and efficacy study . Mol.Pharmacol. .2002 ;(62):864-872

43. 2002 Chen, C.H,Liu, J.J.,Lu, F.J.,Yang, M.L,Lee, Y.S,Huang, T.S. The effect of humic acid on the adhesibility of neutrophils. . Thromb Res. 108:67-76, 2002. .2002 ;(108):67-72

44. 1999 Hong,R.L.,Huang,C.J,Tseng,Y.L,Pang,V.F,Chen,S.T,Liu,J.J. and Chang,F.H.. Direct comparison of liposomal doxorubicin with or without polyethylene glycol coating in C-26 tumor-bearing mice: is surface coating with polyethylene glycol beneficial? . Clin.Cancer Res. .1999 ;(5):3645-3652

45. 1996 Au,L.C,Liu,T.J.,,Shen,H.D,Choo,K.B.,Wang,S.Y. Secretory production of bioactive recombinant human granulocyte-macrophage colony-stimulating factor by a baculovirus expression system . J.Biotechnol .1996

研究計畫

計畫名稱
108 脂質代謝體分析方法開發及檢測
補助單位
世翔國際有限公司

計畫名稱
106 組織再生材料-動物試驗研究計畫
補助單位
瀚醫生技股份有限公司

計畫名稱
105 苦瓜葉抽取物對於腸胃道免疫提昇與降低畜產養殖業抗生素使用模式評估研究
補助單位
行政院農業委員會

計畫名稱
105 新型式茶品製備方法-高含量兒茶素評估計劃
補助單位
丨龍團茶品有限公司

計畫名稱
105 TDI-1701奈米劑型前臨床試驗研究計畫
補助單位
東曜藥業股份有限公司

計畫名稱
104 利用牛樟芝合併化療藥物改善化療藥物抗藥性評估
補助單位
科技部

計畫名稱
104 鹽酸多柔比星脂質體學名藥分析方法開發
補助單位
東曜藥業有限公司

計畫名稱
104 磁操控複方藥物載體材料設計及技術開發(2/2)
補助單位
科技部

計畫名稱
104 蝦紅素臨床應用劑型開發
補助單位
科技部

計畫名稱
104 蝦紅素臨床應用劑型開發
補助單位
聿新生物科技股份有限公司新竹科學園區分公司

計畫名稱
104 開發抗癌用新穎性秋水仙素衍生物
補助單位
科技部

計畫名稱
102 Method development for SB identification
補助單位
STEMBIOSTECHNOLOGIES,INC.

計畫名稱
102 利用體外藥物致敏性標的分子篩選結合抗大腸直腸癌藥物之Lipid-base奈米劑型開發
補助單位
衛生福利部

計畫名稱
102 產學合作計畫-磁操控複方藥物載體材料設計及技術開發(1/2)
補助單位
國立交通大學

計畫名稱
102 以α9-型尼古丁乙醯膽鹼受體為標的乳癌防治新藥之篩選
補助單位
臺北醫學大學

計畫名稱
102 烏苓蔘萃取物毒性試驗
補助單位
康建生物科技股份有限公司

計畫名稱
102 微脂體藥物開發研究諮詢計畫
補助單位
台灣東洋藥品工業股份有限公司

計畫名稱
102 樟芝萃取物急毒性試驗
補助單位
中華兩岸科技人文學術交流協會

計畫名稱
101 利用體外藥物致敏性標的分子篩選結合抗大腸直腸癌藥物之Lipid-base奈米劑型開發
補助單位
衛生福利部

計畫名稱
101 以α9-型尼古丁乙醯膽鹼受體為標的乳癌防治新藥之篩選
補助單位
臺北醫學大學

計畫名稱
100 微脂體藥物製備
補助單位
財團法人生物技術開發中心

計畫名稱
100 利用體外藥物致敏性標的分子篩選結合抗大腸直腸癌藥物之Lipid-base奈米劑型開發
補助單位
行政院衛生署

計畫名稱
100 微脂體藥物傳輸系統發展及其應用在治療脈絡膜新生血管相關眼睛疾病
補助單位
行政院國家科學委員會

計畫名稱
99 微脂體藥物傳輸系統發展及其應用在治療脈絡膜新生血管相關眼睛疾病
補助單位
行政院國家科學委員會

計畫名稱
98 微脂體藥物傳輸系統發展及其應用在治療脈絡膜新生血管相關眼睛疾病
補助單位
行政院國家科學委員會

計畫名稱
98 不同脂肪乳劑對腦部創傷引致之血管內皮細胞發炎反應之影響
補助單位
童綜合醫療社團法人童綜合醫院

計畫名稱
96 The therapy effect of human umbilical cord blood (hUCB)-derived mesenchymal stem cells in lung caner progression and metastasis
補助單位
臺北醫學大學附設醫院

計畫名稱
96 α2-腎上腺素受體促進劑dexmedetomidine對內皮細胞的影響
補助單位
新光醫療財團法人新光吳火獅紀念醫院

計畫名稱
96 利用具不同釋放速度微脂體藥物進行抗癌藥物毒性與療效評估-釋放速度可調式微脂體劑型發展
補助單位
臺北醫學大學新聘教師計畫