莊健盈(Chuang, Jian-Ying) 副教授

Email
chuangcy@tmu.edu.tw
現   職
神經再生醫學博士學位學程 副教授

學經歷

學 歷

畢業學校與學位[修業時間]
國立成功大學基礎醫學研究所 博士
2005/07~2010/07
長庚大學基礎醫學研究所 碩士
2002/08~2004/06
高雄醫學大學生物系 學士
1998/09~2002/06

本校學術經歷

任職單位與職稱[起迄時間]
神經再生醫學博士學位學程副教授
2017/08/01~
神經再生醫學博士學位學程助理教授
2013/08/08~2017/07/31

本校兼職教學行政經歷

服務單位與職稱[起迄時間]
無資料!

其它經歷

任職單位與職稱[起迄時間]
NIDA/NIHVisiting Fellow
2011/08~2013/07
成功大學博士後研究
2010/08~2011/07
NIDA/NIHVisiting Scholar
2009/06~2009/09

專長與研究領域

學門領域
藥理及毒理
醫學之生化及分子生物
幹細胞/再生生物醫學
學術專長
IP
ChIP
Reporter assay

論文著作

清冊下載


1. 2020 Chen TC#,Chuang JY#,Ko CY,Kao TJ,Yang PY,Yu CH, Liu MS, Hu SL, Tsai YT, Chan H, Chang WC*, Hsu TI*. AR ubiquitination induced by the curcumin analog suppresses growth of temozolomide-resistant glioblastoma through disrupting GPX4-Mediated redox homeostasis . Redox Biol .2020 ;(30):101413-101413

2. 2020 Huang YH,Wu YW,Chuang JY,Chang YC,Chang HF,Tao PL, Loh HH, Yeh SH*. Morphine produces potent antinociception, sedation, and hypothermia in humanized mice expressing human mu-opioid receptor splice variants. . Pain .2020

3. 2020 Limanjaya I,Hsu TI,Chuang JY,Kao TJ*. L-selectin activation regulates Rho GTPase activity via Ca+2 influx in Sertoli cell line, ASC-17D cells . Biochem Biophys Res Commun .2020

4. 2020 Lo WL,Hsu TI,Yang WB,Kao TJ,Wu MH,Huang YN, Yeh SH, Chuang JY*. Betulinic acid-mediated tuning of PERK/CHOP signaling by Sp1 inhibition as a novel therapeutic strategy for glioblastoma . Cancers .2020 ;(12)

5. 2020 Yang WB,Hsu CC,Hsu TI,Liou JP,Chang KY,Chen PY, Liu JJ, Yang ST, Wang JY, Yeh SH, Chen RM, Chang WC*, Chuang JY*. Increased activation of HDAC1/2/6 and Sp1 underlies therapeutic resistance and tumor growth in glioblastoma . Neuro-Oncology .2020

6. 2020 Chao PK,Chang HF,Chang WT,Yeh TK,Ou LC,Chuang JY, Tsu-An Hsu J, Tao PL, Loh HH, Shih C, Ueng SH, Yeh SH. BPR1M97, a dual mu opioid receptor/nociceptin-orphanin FQ peptide receptor agonist, produces potent antinociceptive effects with safer properties than morphine. . Neuropharmacology .2020 ;(166):107678

7. 2020 Hung CY,Hsu TI,Chuang JY,Su TP,Chang WC,Hung JJ*. Sp1 in Astrocyte Is Important for Neurite Outgrowth and Synaptogenesis . Mol Neurobiol .2020 ;(57):261-277

8. 2019 Lin HY,Ko CY,Kao TJ,Yang WB,Tsai YT,Chuang JY, Hu SL, Yang PY, Lo WL, Hsu TI*. CYP17A1 Maintains the Survival of Glioblastomas by Regulating SAR1-Mediated Endoplasmic Reticulum Health and Redox Homeostasis . Cancers (Basel) .2019 ;(11):pii: E1378

9. 2019 Chien CH,Chuang JY,Yang ST,Yang WB,Chen PY,Hsu TI, Huang CY, Lo WL, Yang KY, Liu MS, Chu JM, Chung PH, Liu JJ, Chou SW, Chen SH, Chang KY*. Enrichment of superoxide dismutase 2 in glioblastoma confers to acquisition of temozolomide resistance that is associated with tumor-initiating cell subsets . J Biomed Sci .2019 ;(26):77

10. 2019 Tsai YT,Wu AC,Yang WB,Kao TJ,Chuang JY,Chang WC*, Hsu TI*. ANGPTL4 Induces TMZ Resistance of Glioblastoma by Promoting Cancer Stemness Enrichment via the EGFR/AKT/4E-BP1 Cascade . Int J Mol Sci .2019 ;(20):pii: E5625

11. 2019 Chao PK,Chang HF,Ou LC,Chuang JY,Lee PT,Chang WT, Chen SC, Ueng SH, Hsu JT, Tao PL, Law PY, Loh HH, Yeh SH*. Convallatoxin enhance the ligand-induced mu-opioid receptor endocytosis and attenuate morphine antinociceptive tolerance in mice . Sci Rep .2019 ;(9):2405

12. 2019 Wang SM,Lin HY,Chen YL,Hsu TI,Chuang JY,Kao TJ, Ko CY*. CCAAT/enhancer-binding protein delta regulates the stemness of glioma stem-like cells through activating PDGFA expression upon inflammatory stimulation . J Neuroinflammation .2019 ;(16):146

13. 2018 Chio CC,Chen KY,Chang CK,Chuang JY ,Liu CC,Liu SH, Chen RM. Improved effects of honokiol on temozolomide-induced autophagy and apoptosis of drug-sensitive and -tolerant glioma cells . BMC Cancer .2018 ;(18)

14. 2018 Chang CJ,Chang MY,Chou SY,Huang CC,Chuang JY,Hsu TI, Chang HF, Wu YH, Wu CC, Morales D, Kania A, Kao TJ. Ephexin1 is required for Eph-Mediated limb trajectory of spinal motor axons . Journal of Neuroscience .2018 ;(38):2043-2056

15. 2018 Ko CY,Lin CH,Chuang JY,Chang WC,Hsu TI. MDM2 Degrades Deacetylated Nucleolin Through Ubiquitination to Promote Glioma Stem-Like Cell Enrichment for Chemotherapeutic Resistance . Molecular Neurobiology .2018 ;(55):3211-3223

16. 2018 Lin CY,Yang ST,Shen SC,Hsieh YC,Hsu FT,Chen CY, Chiang YH, Chuang JY, Chen KY, Hsu TI, Leong WC, Su YK, Lo WL, Yeh YS, Patria YN, Shih HM, Chang CC, Chou SY. Serum amyloid A1 in combination with integrin αVβ3 increases glioblastoma cells mobility and progression . Molecular Oncology .2018 ;(12):756-771

17. 2018 Chang CJ,Chang MY,Lee YC,Chen KY,Hsu TI,Wu YH, Chuang JY*, Kao TJ*. Nck2 is essential for limb trajectory selection by spinal motor axons . Developmental Dynamics .2018 ;(247):1043-1056

18. 2018 Yang WB,Chuang JY,Ko CY,Chang WC,Hsu TI. Dehydroepiandrosterone induces temozolomide resistance through modulating phosphorylation and acetylation of Sp1 in glioblastoma . Mol Neurobiol .2018

19. 2018 Wu CC,Lee PT,Kao TJ,Chou SY,Su RY,Lee YC, Yeh SH, Liou JP, Hsu TI, Su TP, Chuang CK, Chang WC*, Chuang JY*. Upregulation of Znf179 acetylation by SAHA protects cells against oxidative stress . Redox Biol .2018 ;(19):74-80

20. 2017 Chang KY,Huang CT,Hsu TI,Hsu CC,Liu JJ,Chuang CK, Hung JJ, Chang WC, Tsai KK, Chuang JY*. Stress stimuli induce cancer-stemness gene expression via Sp1 activation leading to therapeutic resistance in glioblastoma. . Biochem Biophys Res Commun .2017 ;(493):14-19

21. 2017 Chuang JY,Kao TJ,Lin SH,Wu AC,Lee PT,Su TP, Yeh SH, Lee YC, Wu CC, Chang WC. Specificity protein 1-zinc finger protein 179 pathway is involved in the attenuation of oxidative stress following brain injury . Redox Biology .2017 ;(11):135-143

22. 2017 Ke YY,Huang YH,Chien WC,Loh HH,Chuang JY*,Yeh SH*. Mapping the naloxone binding sites on the mu-opioid receptor using cell-based photocrosslinkers . Biochim Biophys Acta .2017 ;(1865):336-343

23. 2017 Chao PK,Ueng SH,Ou LC,Yeh TK,Chang WT,Chang HF, Chen SC, Tao PL, Law PY, Loh H, Cheng MF, Chuang JY, Chen CT, Shih C, Yeh SH. 1-(2,4-Dibromophenyl)-3,6,6-trimethyl-1,5,6,7-tetrahydro-4H-indazol-4-one: A Novel Opioid Receptor Agonist with Less Accompanying Gastrointestinal Dysfunction than Morphine. . Anesthesiology .2017 ;(126):952-966

24. 2017 Chuang JY,Lo WL,Ko CY,Chou SY,Chen RM,Chang KY, Hung JJ, Su WC, Chang WC*, Hsu TI*.. Upregulation of CYP17A1 by Sp1-mediated DNA Demethylation Confers Temozolomide Resistance through DHEA-Mediated Protection in Glioma. . Oncogenesis .2017 ;(6):e339

25. 2017 Chang KY,Hsu TI,Hsu CC,Tsai SY,Liu JJ,Chou SW, Liu MS, Liou JP, Ko CY, Chen KY, Hung JJ, Chang WC, Chuang CK, Kao TJ, Chuang JY. Specificity protein 1-modulated superoxide dismutase 2 enhances temozolomide resistance in glioblastoma, which is independent of O6-methylguanine-DNA methyltransferase . Redox Biol .2017 ;(13):655-664

26. 2017 Hung CY,Wang YC,Chuang JY,Young MJ,Liaw H,Chang WC, and Hung JJ. Nm23-H1-stabilized hnRNPA2/B1 promotes internal ribosomal entry site (IRES)-mediated translation of Sp1 in the lung cancer progression . Sci Rep .2017 ;(7):9166

27. 2016 Su TC,Lin SH,Lee PT,Yeh SH,Hsieh TH,Chou SY, Su, TP Hung JJ, Chang WC, Lee YC*, Chuang JY*. The sigma-1 receptor-Zinc finger protein 179 pathway protects against hydrogen peroxide-induced cell injury . Neuropharmacology .2016 ;(105):1-9

28. 2016 Hsu CC,Chang WC,Hsu TI,Liu JJ,Yeh SH,Wang JY, Liou JP, Ko CY, Chang KY, Chuang JY. Suberoylanilide hydroxamic acid represses glioma stem-like cells . Journal of Biomedical Science .2016 ;(23):81

29. 2015 Tsai SA#,Chuang JY#,Tsai MS,Wang XF,Xi ZX,Hung JJ, Chang WC, Bonci A, Su TP*. Sigma-1 receptor mediates cocaine-induced transcriptional regulation by recruiting chromatin-remodeling factors at the nuclear envelope. . Proc Natl Acad Sci U S A .2015 ;(112):E6562-E6570

30. 2014 Wang SA,Hung CY,Chuang JY,Chang WC,Hsu TI,Hung JJ. Phosphorylation of p300 increases its protein degradation to enhance the lung cancer progression . Biochim Biophys Acta .2014 ;(1843):1135-1149

31. 2014 Lee PT,Chao PK,Ou LC,Chuang JY,Lin YC,Chen SC, Chang HF, Law PY, Loh HH, Chao YS, Su TP, Yeh SH*. Morphine drives internal ribosome entry site-mediated hnRNP K translation in neurons through opioid receptor-dependent signaling. . Nucleic Acids Res .2014 ;(42):13012-13025

32. 2014 Yang HC,Chuang JY,Jeng WY,Liu CI,Wang AH,Lu PJ, Chang WC, Hung JJ*. Pin1-mediated Sp1 phosphorylation by CDK1 increases Sp1 stability and decreases its DNA-binding activity during mitosis. . Nucleic Acids Res .2014 ;(42):13573-13587

33. 2013 Kourrich S,Hayashi T#,Chuang JY#,Tsai SY,Su TP,Bonci A. Dynamic interaction between Sigma-1 receptor and Kv1.2 shapes neuronal and behavioral responses to cocaine . Cell .2013 ;(152):236-247

34. 2012 Chuang JY,Wang SA,Yang WB,Hung CY,Su TP,Chang WC, Hung JJ. Sp1 phosphorylation by cyclin-dependent kinase 1/cyclin B1 represses its DNA-binding activity during mitosis in cancer cells . Oncogene .2012 ;(31):2946-4959

35. 2011 Chuang JY,Chang WC,Hung JJ. Hydrogen peroxide induces Sp1 methylation and thereby suppresses cyclin B1 via recruitment of Suv39H1 and HDAC1 in cancer cells . Free Radic Biol Med .2011 ;(51):2309-2318

36. 2011 Chuang JY,Hung JJ. Overexpression of HDAC1 induces cellular senescence by Sp1/PP2A/pRb pathway . Biochem Biophys Res Commun .2011 ;(407):587-592

37. 2010 Chang LK,Chuang JY,Nakao M,Liu ST. MCAF1 and synergistic activation of the transcription of Epstein-Barr virus lytic genes by Rta and Zta . Nucleic Acids Res .2010 ;(38):4687-700

38. 2009 Chuang JY,Wu CH,Lau MD,Chang WC,Hung JJ. Overexpression of Sp1 leads to p53-dependent apoptosis in cancer cells . Int J Cancer .2009 ;(125):2066-2079

39. 2009 Wang SA,Chuang JY,Yeh SH,Wang YT,Liu YW,Chang WC, Hung JJ. Heat shock protein 90 is important for Sp1 stability during mitosis . J Mol Biol .2009 ;(387):1106-1119

40. 2008 Wang YT,Chuang JY,Shen MR,Yang WB,Chang WC,Hung JJ. Sumoylation of specificity protein 1 augments its degradation by changing the localization and increasing the specificity protein 1 proteolytic process . J Mol Biol .2008 ;(380):869-885

41. 2008 Chang LK,Liu ST,Kao CE,Wang WH,Chuang JY,Bianchi E, Hong YR. Enhancement of transactivation activity of Rta of Epstein-Barr virus by RanBPM . J Mol Biol .2008 ;(379):231-242

42. 2008 Chuang JY,Wang YT,Yeh SH,Liu YW,Chang WC,Hung JJ. Phosphorylation by c-Jun NH2-terminal kinase 1 regulates the stability of transcription factor Sp1 during mitosis . Mol Biol Cell .2008 ;(19):1139-1151

43. 2006 Liu ST,Wang WH,Hong YR,Chuang JY,Lu PJ,Chang LK. Sumoylation of Rta of Epstein-Barr virus is preferentially enhanced by PIASxbeta . Virus Res .2006 ;(119):163-170

44. 2005 Chang LK,Chuang JY,Honh YR,Ichimura T,Nakao M,Liu ST. Activation of Sp1-mediated transcription by Rta of Epstein-Barr virus via an interaction with MCAF1 . Nucleic Acids Res .2005 ;(33):6528-6539

45. 2003 Chang LK,Wei TT,Chiu YF,Tung CP,Chuang JY,Hung SK, Li C, Liu ST. Inhibition of Epstein–Barr virus lytic cycle by (−)-epigallocatechin gallate . Biochem Biophys Res Commun .2003 ;(301):1062-1068

研究計畫

計畫名稱
108 調整PERK-eIF2a-CHOP信號可作為膠質母細胞瘤的新治療策略
補助單位
奇美醫療財團法人奇美醫院

計畫名稱
108 腦創傷後的神經再生研究(1/5)
補助單位
科技部

計畫名稱
107 “愛憶欣-伏立諾他”聯合藥物MPT0G604對惡性腦瘤幹細胞的抗增生作用
補助單位
阮綜合醫療社團法人阮綜合醫院

計畫名稱
107 轉錄因子Sp1在癌症形成之基礎及轉譯研究-研究Sp1在化療藥物抗性的作用(3/3)
補助單位
科技部

計畫名稱
106 篩選一有效“愛憶欣-伏立諾他”聯合藥物用於治療膠質母細胞瘤
補助單位
阮綜合醫療社團法人阮綜合醫院

計畫名稱
106 轉錄因子Sp1在癌症形成之基礎及轉譯研究-研究Sp1在化療藥物抗性的作用(2/3)
補助單位
科技部

計畫名稱
106 研究腦癌發展獲得性抗藥能力過程中-HDAC6調節Sp1去乙醯化所扮演的角色
補助單位
科技部

計畫名稱
105 研究辛二醯基苯胺羥胺酸提升神經保護因子Znf179表達的作用
補助單位
阮綜合醫療社團法人阮綜合醫院

計畫名稱
105 可卡因促使Sig-1R局部化於核膜與emerin-HDACs抑制因子複合物結合來調節MAOB表達(3/3)
補助單位
科技部

計畫名稱
105 可卡因促使Sig-1R局部化於核膜與emerin-HDACs抑制因子複合物結合來調節MAOB表達(3/3)
補助單位
科技部

計畫名稱
105 轉錄因子Sp1在癌症形成之基礎及轉譯研究-研究Sp1在化療藥物抗性的作用(1/3)
補助單位

計畫名稱
104 可卡因促使Sig-1R局部化於核膜與emerin-HDACs抑制因子複合物結合來調節MAOB表達(2/3)
補助單位
科技部

計畫名稱
104 可卡因促使Sig-1R局部化於核膜與emerin-HDACs抑制因子複合物結合來調節MAOB表達(2/3)
補助單位
科技部

計畫名稱
103 篩選一個具有保護神經而且可能發展為腦創傷治療藥物的Sigma 1受體促效劑
補助單位
臺北醫學大學附設醫院

計畫名稱
103 可卡因促使Sig-1R局部化於核膜與emerin-HDACs抑制因子複合物結合來調節MAOB表達(1/3)
補助單位
科技部

計畫名稱
103 可卡因促使Sig-1R局部化於核膜與emerin-HDACs抑制因子複合物結合來調節MAOB表達(1/3)
補助單位
科技部

計畫名稱
102 在過氧化氫誘導細胞死亡模式中ZNF179與 Sp1 所扮演的神經保護功能研究
補助單位
國泰醫療財團法人國泰綜合醫院

計畫名稱
102 TMU102-AE1-B25
補助單位
臺北醫學大學新聘教師計畫