王智揚(Wang, Chih-Yang) 助理教授

現   職
癌症生物學與藥物研發博士學位學程 助理教授


學 歷

國立成功大學基礎醫學研究所 博士
國立陽明大學傳統醫藥研究所 碩士
中國醫藥大學中國醫藥暨中藥資源學系 學士








Biological Biochemistry and Molecular Biology



1. 2020 Hsu HP,Wang CY,Hsieh PY,Fang JH,Chen YL. Knockdown of serine/threonine-protein kinase 24 promotes tumorigenesis and myeloid-derived suppressor cell expansion in an orthotopic immunocompetent gastric cancer animal model . Journal of Cancer .2020

2. 2020 Chih-Yang Wang,Chung-Chieh Chiao, Nam Nhut Phan,Chung-Yen Li,Zheng-Da Sun,Jia-Zhen Jiang, Jui-Hsiang Hung, Yi-Ling Chen, Meng-Chi Yen, Tzu-Yang Weng, Wei-Ching Chen, Hui-Ping Hsu, Ming-Derg Lai. Gene signatures and potential therapeutic targets of amino acid metabolism in estrogen receptor-positive breast cancer . American Journal of Cancer Research .2020

3. 2020 Phan NN,Liu S,Wang CY,Hsu HP,Lai MD,Li CY,Chen CF, Chiao CC, Yen MC, Sun Z, Jiang JZ.. Overexpressed gene signature of EPH receptor A/B family in cancer patients-comprehensive analyses from the public high-throughput database. . International Journal of Clinical and Experimental Pathology .2020

4. 2020 Hagerling C,Owyong M,Sitarama V,Wang CY,Lin C,van den Bijgaart RJE, Koopman CD, Brenot A, Nanjaraj A, Wärnberg F, Jirström K, Klein OD, Werb Z, Plaks V.. LGR5 in breast cancer and ductal carcinoma in situ: a diagnostic and prognostic biomarker and a therapeutic target. . BMC Cancer .2020

5. 2020 Gene signatures of SARS-CoV/SARS-CoV-2-infected ferret lungs in short- and long-term models. . Infection, Genetics and Evolution .2020

6. 2020 Liu HL,Yeh IJ,Phan NN,Wu YH,Yen MC,Hung JH, Chiao CC, Chen CF, Sun Z, Jiang JZ, Hsu HP, Wang CY, Lai MD.. Gene signatures of SARS-CoV/SARS-CoV-2-infected ferret lungs in short- and long-term models. . Infection, Genetics and Evolution .2020

7. 2020 Lin YY,Wang CY,Phan NN,Chiao CC,Li CY,Sun Z, Hung JH, Chen YL, Yen MC, Weng TY, Hsu HP, Lai MD.. PODXL2 maintains cellular stemness and promotes breast cancer development through the Rac1/Akt pathway. . International Journal of Medical Sciences .2020

8. 2020 Cheng LC,Chao YJ,Wang CY,Phan NN,Chen YL,Wang TW, Hsu HP, Lin YJ, Shan YS, Lai MD.. Cancer-Derived Transforming Growth Factor-β Modulates Tumor-Associated Macrophages in Ampullary Cancer. . OncoTargets and Therapy .2020

9. 2020 Cheng LC,Chao YJ,Overman MJ,Wang CY,Phan NN,Chen YL, Wang TW, Hsu HP, Shan YS, Lai MD.. Increased expression of secreted frizzled related protein 1 (SFRP1) predicts ampullary adenocarcinoma recurrence. . Scientific Reports .2020

10. 2020 Wu CC,Ekanem TI,Phan NN,Loan DTT,Hou SY,Lee KH, Wang CY.. Gene signatures and prognostic analyses of the Tob/BTG pituitary tumor-transforming gene (PTTG) family in clinical breast cancer patients. . International Journal of Medical Sciences .2020

11. 2020 Wang CY,Chao YJ,Chen YL,Wang TW,Phan NN,Hsu HP, Shan YS, Lai MD. Upregulation of peroxisome proliferator-activated receptor-α and lipid metabolism pathway promotes carcinogenesis of ampullary cancer . International Journal of Medical Sciences .2020

12. 2020 Chen PS,Hsu HP,Phan NN,Yen MC,Chen FW,Liu YW, Lin FP, Feng SY, Cheng TL, Yeh PH, Omar HA, Sun Z, Jiang JZ, Chan YS, Lai MD, Wang CY, Hung JH. CCDC167 as a potential therapeutic target and regulator of cell cycle-related networks in breast cancer . Aging .2020

13. 2020 Wu PS,Yen JH,Wang CY,Chen PY,Hung JH,Wu MJ. 8-Hydroxydaidzein, an Isoflavone from Fermented Soybean, Induces Autophagy, Apoptosis, Differentiation, and Degradation of Oncoprotein BCR-ABL in K562 Cells . Biomedicines .2020

14. 2019 Chang CP,Phan NN,Shen MR,Hsu HP. Mutation of the PTCH1 gene predicts recurrence of breast cancer. . Scientific Reports .2019

15. 2019 van GM,Dejmek A, Jirström K,Werb Z. Immune effector monocyte-neutrophil cooperation induced by the primary tumor prevents metastatic progression of breast cancer. . Proceedings of the National Academy of Sciences .2019

16. 2019 Barras D,Matli M,Miao Y,Garcia KC,Tejpar S,Delorenzi M, Venook AP, Nixon AB, Warren RS, Roose JP, Depeille P. RasGRP1 is a potential biomarker to stratify anti-EGFR therapy response in colorectal cancer. . JCI Insight .2019

17. 2019 Owyong M,Chou J,Van den Bijgaart,RJ,Kong N,Efe G, Maynard C, Talmi-Frank D, Solomonov I, Koopman C, Hadler-Olsen E, Headley M, Lin C, Wang CY, Sagi I, Werb Z, Plaks V. MMP9 modulates the metastatic cascade and immune landscape for breast cancer anti-metastatic therapy . Life Science Alliance .2019

18. 2018 Weng TY,Wu HF,Li CY,Hung YH,Chang YW,Chen YL, Hsu HP, Chen YH, Wang CY, Chang JY, Lai MD. Homoharringtonine induced immune alteration for an Efficient Anti-tumor Response in Mouse Models of Non-small Cell Lung Adenocarcinoma Expressing Kras Mutation. . Scientific Reports .2018

19. 2018 Phan NN,Wang CY,Li KL,Chen CF,Chiao CC,Yu HG, Huang PL, Lin YC. Distinct expression of CDCA3, CDCA5, and CDCA8 leads to shorter relapse free survival in breast cancer patient. . Oncotarget .2018

20. 2017 Wang CY,Li CY,Hsu HP,Cho CY,Yen MC, Weng TY,Chen WC, Hung YH, Lee KT, Hung JH, Chen YL, Lai MD. PSMB5 plays a dual role in cancer development and immunosuppression. . American Journal of Cancer Research .2017

21. 2017 Shan YS,Hsu HP, Lai MD,Hung YH, Wang CY,Yen MC, Chen YL. Cyclin D1 overexpression correlates with poor tumor differentiation and prognosis in gastric cancer. . Oncology Letters .2017

22. 2017 Cooke DL,McCoy DB,Halbach VV, Hetts SW,Amans MR,Dowd CF, Higashida RT, Lawson D, Nelson J, Wang CY, Kim H, Werb Z, McCulloch C, Hashimoto T, Su H, Sun Z.. Endovascular Biopsy: In Vivo Cerebral Aneurysm Endothelial Cell Sampling and Gene Expression Analysis. . Translational Stroke Research .2017

23. 2017 Phan NN,Wang CY,Chen CF,Sun Z,Lai MD,Lin YC. Voltage-gated calcium channels: Novel targets for cancer therapy. . Oncology Letters .2017

24. 2017 Shahi P, Wang CY, Chou J,Hagerling C,Gonzalez Velozo ,Ruderisch A, Yu Y, Lai MD, Werb Z. GATA3 targets semaphorin 3B in mammary epithelial cells to suppress breast cancer progression and metastasis. . Oncogene .2017

25. 2017 Sun Z,Wang CY,Lawson DA,Kwek S,Velozo HG,Owyong M,Lai MD, Fong L, Wilson M, Su H, Werb Z, Cooke DL. Single-cell RNA sequencing reveals gene expression signatures of breast cancer-associated endothelial cells. . Oncotarget .2017

26. 2017 Thuy TD,Phan NN,Wang C,Yu HG, Wang SY,Huang PL, Do YY, Lin YC. Novel therapeutic effects of sesamin on diabetes-induced cardiac dysfunction . Molecular Medicine Reports .2017

27. 2017 Shahi P,Wang CY,Lawson DA,Slorach EM,Lu A, Yu Y, Lai MD, Gonzalez Velozo H, Werb Z. ZNF503/Zpo2 drives aggressive breast cancer progression by down-regulation of GATA3 expression . Proceedings of the National Academy of Sciences .2017

28. 2017 Wang CY,Shahi P,Huang JT,Phan NN,Sun Z,Lin YC, Lai MD, Werb Z. Systematic analysis of the achaete-scute complex-like gene signature in clinical cancer patients . Molecular and Clinical Oncology .2017

29. 2016 Hung YH,Huang HL,Chen WC,Yen MC,Cho CY,Weng TY, Wang CY, Chen YL, Chen LT, Lai MD. Argininosuccinate lyase interacts with cyclin A2 in cytoplasm and modulates growth of liver tumor cells . Oncology Reports .2016

30. 2016 Huang HL,Chen WC,Hsu HP,Cho CY,Hung YH,Wang CY, Lai MD. Silencing of argininosuccinate lyase inhibits colorectal cancer formation . Oncology Reports .2016

31. 2016 Chen WC,Hsu HP,Li CY,Yang YJ,Hung YH,Cho CY, Wang CY, Weng TY, Lai MD. Cancer stem cell marker CD90 inhibits ovarian cancer formation via β3 integrin . International Journal of Oncology .2016

32. 2016 Thi Do D,Phan NN,Wang CY, Sun Z,Lin YC. Novel regulations of MEF2-A, MEF2-D, and CACNA1S in the functional incompetence of adipose-derived mesenchymal stem cells by induced indoxyl sulfate in chronic kidney disease . Cytotechnology .2016

33. 2016 Weng TY,Wang CY,Hung YH,Chen WC,Chen YL, Lai MD. Differential Expression Pattern of THBS1 and THBS2 in Lung Cancer: Clinical Outcome and a Systematic-Analysis of Microarray Databases . PLoS One .2016

34. 2016 Chen WC,Wang CY,Hung YH,Weng TY, Yen MC,Lai MD. Systematic Analysis of Gene Expression Alterations and Clinical Outcomes for Long-Chain Acyl-Coenzyme A Synthetase Family in Cancer . PLoS One .2016

35. 2016 Cho CY,Lee KT,Chen WC,Wang CY,Chang YS,Huang HL, Hsu HP, Yen MC, Lai MZ, Lai MD. MST3 promotes proliferation and tumorigenicity through the VAV2/Rac1 signal axis in breast cancer . Oncotarget .2016

36. 2015 Chen WC,Chang YS,Hsu HP,Yen MC,Huang HL,Cho CY, Wang CY, Weng TY, Lai PT, Chen CS, Lin YJ, Lai MD. Therapeutics targeting CD90-integrin-AMPK-CD133 signal axis in liver cancer . Oncotarget .2015

37. 2015 Huang HL,Chen WC,Hsu HP,Cho CY,Hung YH,Wang CY, Lai MD. Argininosuccinate lyase is a potential therapeutic target in breast cancer . Oncology Reports .2015

38. 2015 Lai MD. Argininosuccinate lyase is a potential therapeutic target in breast cancer . Oncology Reports .2015

39. 2015 Wang CY,Lai MD,Phan NN,Sun Z,Lin YC. Meta-Analysis of Public Microarray Datasets Reveals Voltage-Gated Calcium Gene Signatures in Clinical Cancer Patients . PLoS One .2015

40. 2015 Kessenbrock K, Wang CY,Werb Z. Matrix metalloproteinases in stem cell regulation and cancer . Matrix Biology .2015

41. 2015 Lawson DA,Bhakta NR,Kessenbrock K,Prummel KD,Yu Y,Takai K, Zhou A, Eyob H, Balakrishnan S, Wang CY, Goga A, Werb Yaswen P, . Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells . Nature .2015

42. 2015 Depeille P,Henricks LM,Van de Ven RA,Lemmens E,Wang CY,Matli M, Werb Z, Haigis KM, Donner D, Warren R, Roose JP. RasGRP1 opposes proliferative EGFR-SOS1-Ras signals and restricts intestinal epithelial cell growth . Nature Cell Biology .2015

43. 2015 Sun Z,Lawson DA,Sinclair E,Wang CY,Lai MD,Hetts SW, Higashida RT, Dowd CF, Halbach VV, Werb Z, Su H, Cooke DL. Endovascular biopsy: Strategy for analyzing gene expression profiles of individual endothelial cells obtained from human vessels . Biotechnology Reports .2015

44. 2014 Shahi P,Slorach EM,Wang CY,Chou J,Lu A,Ruderisch A, Werb Z. The Transcriptional Repressor ZNF503/Zeppo2 Promotes Mammary Epithelial Cell Proliferation and Enhances Cell Invasion . The Journal of Biological Chemistry .2014

45. 2014 Ou KC,Wang CY,Liu KT,Chen YL,Chen YC,Lai MD, Yen MC. Optimization protein productivity of human interleukin-2 through codon usage, gene copy number and intracellular tRNA concentration in CHO cells . Biochemical and Biophysical Research Communications .2014

46. 2014 Phan NN,Wang CY,Lin YC. The novel regulations of MEF2A, CAMKK2, CALM3, and TNNI3 in ventricular hypertrophy induced by arsenic exposure in rats . Toxicology .2014

47. 2014 Hung YH,Chan YS,Chang YS, Lee KT,Hsu HP,Yen MC, Chen WC, Wang CY, Lai MD. Fatty acid metabolic enzyme acyl-CoA thioesterase 8 promotes the development of hepatocellular carcinoma . Oncology Reports .2014

48. 2014 Weng TY,Yen MC,Huang CT,Hung JJ,Chen YL,Chen WC, Wang CY, Chang JY, Lai MD. DNA vaccine elicits an efficient antitumor response by targeting the mutant Kras in a transgenic mouse lung cancer model . Gene Therapy .2014

49. 2013 Weng TY,Huang SS,Yen MC, Lin CC,Chen YL,Lin CM, Chen WC, Wang CY, Chang JY, Lai MD. A novel cancer therapeutic using thrombospondin 1 in dendritic cells . Molecular Therapy .2013

50. 2012 Kuo JJ,Wang CY,Lee TF,Huang YT,Lin YL. Paeoniae radix reduces PDGF-stimulated hepatic stellate cell migration . Planta Medica .2012


109 探討胺基酸代謝基因標誌及其在雌激素高表達乳癌病人之治療機制(2/2)

108 新聘教師研究補助

108 探討胺基酸代謝基因標誌及其在雌激素高表達乳癌病人之治療機制(1/2)