吳介信(Wu, Chieh-Hsi) 教授

Email
chhswu@tmu.edu.tw
現   職
副校長室 副校長
藥物科學學科 教授

學經歷

學 歷

畢業學校與學位[修業時間]
俄亥俄州立大學藥理學研究所 博士
1989/09~1994/04
臺北醫學大學藥學系 學士
1982/09~1986/06

本校學術經歷

任職單位與職稱[起迄時間]
藥物科學學科教授
2013/08/01~

本校兼職教學行政經歷

服務單位與職稱[起迄時間]
跨領域學院院長
2018/02/01 ~ 2018/12/31
副校長室副校長
2017/08/01 ~
跨領域學院籌備處院長
2017/08/01 ~ 2018/01/31
臨床藥物基因體學暨蛋白質體學碩
2014/08/01 ~
生藥學研究所
2014/08/01 ~
中草藥臨床藥物研發博士學位學程
2013/08/01 ~
藥學院院長
2013/08/01 ~ 2017/07/31

其它經歷

任職單位與職稱[起迄時間]
中國醫藥大學藥學系教授
2006/03/01~2013/07/31
中國醫藥大學藥學系副教授
1997/01/01~2006/02/28

專長與研究領域

學門領域
藥理學
基因治療學
心血管疾病學
分子生物學
藥理及毒理
學術專長
氣球擴張之血管再阻塞動物模型
粥狀動脈硬化之評估
血管新生之功能性評估
蛋白質體學
SNP基因突變之分析

論文著作

清冊下載


1. 2019 Pan CH,Chen CJ,Shih CM,Wang MF,Wang JY,Wu CH. Oxidative stress-induced cellular senescence desensitizes cell growth and migration of vascular smooth muscle cells through down-regulation of platelet-derived growth factor receptor-beta . Aging .2019 ;(11)

2. 2018 Wu CH,Liu FC,Pan CH,Lai MT,Lan SJ,Wu CH, Sheu MJ*. Suppression of Cell Growth, Migration and Drug Resistance by Ethanolic Extract of Antrodia cinnamomea in Human Lung Cancer A549 Cells and C57BL/6J Allograft Tumor Model . International Journal of Molecular Sciences .2018 ;(19):791-805

3. 2017 Liao HF,Pan CH,Chou PY,Chen YF,Wu TS,Sheu MJ, Wu CH. Toxicological effects of NCKU-21, a phenanthrene derivative, on cell growth and migration of A549 and CL1-5 human lung adenocarcinoma cells . PLoS One .2017 ;(12)

4. 2017 Hsieh CH,Pai P,Wu JP,Ho TJ,Wu CH,Shibu MA, Day CH, Viswanadha VP, Chuang HL, Huang CY. Activation of IGF-I Survival Signaling and Its Compensative Inhibition of the Cardiac Apoptosis on Carotid Arteries Balloon-Injured Rat Hearts . Chinese Journal of Physiology .2017 ;(60):166-173

5. 2017 Xu W,Li X,Lin N,Zhang X,Huang X ,Wu T, Tai Y, Chen S, Wu CH, Huang M, Wu S. Pharmacokinetics and tissue distribution of five major triterpenoids after oral administration of Rhizoma Alismatis extract to rats using ultra high-performance liquid chromatography-tandem mass spectrometry . Journal of pharmaceutical and biomedical analysis .2017 ;(146):314-323

6. 2017 Li PC,Siddiqi IN,Mottok A,Loo EY,Wu CH,Cozen W, Steidl C, Shih JC. Monoamine oxidase A is highly expressed in classical Hodgkin lymphoma . Journal of Pathology .2017 ;(243):220-229

7. 2017 Pan CH,Li PC,Chien YC,Yeh WT,Liaw CC,Sheu MJ, Wu CH*. Suppressive activities and mechanisms of ugonin J on vascular smooth muscle cells and balloon angioplasty‐induced neointimal hyperplasia . Phytotherapy Research .2017

8. 2016 Wu CH,Pan CH,Lee CK,Sheu MJ,Liu FC,Wang GJ, Wu CH. Antiobesity and antihyperlipidaemic effects of Yan-Sheng-Yin in animals and humans . Journal of Functional Foods .2016 ;(24):173-182

9. 2016 Yun-Lung Chung,Chun-Hsu Pan,Charles C.-N. Wang,Kai-Cheng Hsu,Ming-Jyh Sheu,Hai-Feng Chen, Chieh-Hsi Wu. Methyl Protodioscin, a Steroidal Saponin, Inhibits Neointima Formation in Vitro and in Vivo . Journal of natural products .2016

10. 2015 Li PC,Sheu MJ,Ma WF,Pan CH,Sheu JH,Wu CH. Anti-Restenotic Roles of Dihydroaustrasulfone Alcohol Involved in Inhibiting PDGF-BB-Stimulated Proliferation and Migration of Vascular Smooth Muscle Cells . Marine drugs .2015 ;(13):3046-3060

11. 2015 Lin WL,Hsieh YW,Lin CL,Sung FC,Wu CH,Kao CH. A population-based nested case-control study: the use of 5-alpha-reductase inhibitors and the increased risk of osteoporosis diagnosis in patients with benign prostate hyperplasia . Clinical Endocrinology .2015 ;(82):503-508

12. 2014 Chen SC,Chien YC,Pan CH,Sheu JH*,Chen CY*,Wu CH*. Inhibitory effect of Dihydroaustrasulfone alcohol on the migration of human non-small cell lung carcinoma A549 cells and the antitumor effect on a Lewis lung carcinoma-bearing tumor model in C57BL/6J mice . Marine Drugs .2014 ;(12):196-213

13. 2014 Pei-Chuan Li,Chun-Hsu Pan,Ming-Jyh Sheu,Chin-Ching Wu,Wei-Fen Ma,Chieh-Hsi Wu. Deep Sea Water Prevents Balloon Angioplasty-Induced Hyperplasia through MMP-2: An In Vitro and In Vivo Study . PLOS One .2014 ;(9):e96927

14. 2014 Hsiu-Mei Chiang*,Yin-Chih Chien,Chieh-Hsi Wu,Yueh-Hsiung Kuo,Wan-Chen Wu,Yu-Yun Pan, Yu-Han Su, Kuo-Ching Wen*. Hydroalcoholic extract of Rhodiola rosea L. (Crassulaceae) and its hydrolysate inhibit melanogenesis in B16F0 cells by regulating the CREB/MITF/tyrosinase pathway . Food and Chemical Toxicology .2014 ;(65):129-139

15. 2014 Chun-Hsu Pan,Wen-Hsin Lin,Yi-Chung Chien,Fon-Chang Liu,Ming-Jyh Sheu,Yueh-Hsiung Kuo*, Chieh-Hsi Wu*. K20E, an oxidative-coupling compound of methyl caffeate, exhibits anti-angiogenic activities through down-regulations of VEGF and VEGF receptor-2 . Toxicology and Applied Pharmacology .2014 ;(282):215-226

16. 2014 Chung YL†,Pan CH†,Liou WH,Sheu MJ,Lin WH,Tsung-Chih Chen, Hsu-Shan Huang, Chieh-Hsi Wu*. NSC746364, a G-Quadruplex Stabilizing Agent, Suppresses Cell Growth of A549 Human Lung Cancer Cells through Activation of ATR/Chk1-Dependent Pathway . Journal of Pharmacological Sciences .2014 ;(124):7-17

17. 2013 Wang YJ,Lo TY,Wu CH,Liu DM*. Electrophoretic coating of amphiphilic chitosan colloids on regulating cellular behaviour . Journal of the Royal Society Interface .2013 ;(10):201304

18. 2013 Liu FC,Lai MT,Chen YY,Lin WH,Chang SJ,Sheu MJ, Wu CH*. Elucidating the inhibitory mechanisms of the ethanolic extract of the fruiting body of Antrodia cinnamomea on the proliferation and migration of murine leukemia WEHI-3 cells and their tumorigenicity in a BALB/c Allograft Tumor Model . Phytomedicine .2013 ;(20):874-882

19. 2013 Sheu MJ,Chou PY,Lin WH,Pan CH,Chien YC,Chung YL, Liu FC, Wu CH*. Deep Sea Water Modulates Blood Pressure and Exhibits Hypolipidemic Effects via AMPK-ACC Pathway: an in vivo Study . Marine drugs .2013 ;(11):2183-2202

20. 2013 Liu FC,Pan CH,Lai MT,Chang SJ,Chung JG,Wu CH*. Gan-Lu-Yin Inhibits Proliferation and Migration of Murine WEHI-3 Leukemia Cells and Tumor Growth in BALB/C Allograft Tumor Model . Evidence-based Complementary and Alternative Medicine .2013 ;(2013):684071

21. 2013 Sheu MJ,Lin HY,Yang YH,Chou CJ,Chien YC,Wu TS, Wu CH*. Demethoxycurcumin, a major active curcuminoid from Curcuma longa, suppresses balloon injury-induced vascular smooth muscle cell migration and neointima formation: an in vitro and in vivo study . Molecular Nutrition & Food Research .2013 ;(57):1586-1597

22. 2013 Pan CH,Tsai CH,Liu FC,Fan MJ,Sheu MJ,Hsieh WT, Wu CH*. Influence of different particle processing on hypocholesterolemic and antiatherogenic activities of yam (Dioscorea pseudojaponica) in cholesterol-fed rabbit model . Journal of the Science of Food and Agriculture .2013 ;(93):1278-1283

23. 2012 Chien YC,Sheu MJ*,Wu CH,Lin WH,Chen YY,Cheng PL, Cheng HC*. A Chinese herbal formula . BMC Complementary and Alternative Medicine .2012 ;(12):137-148

24. 2012 Chien YC,Huang GJ,Cheng HC,Wu CH,Sheu MJ*. Hispolon Attenuates Balloon-Injured Neointimal Formation and Modulates Vascular Smooth Muscle Cell Migration via AKT and ERK Phosphorylation . Journal of Natural Products .2012 ;(75):1524-1533

25. 2012 Pan CH,Tsai CH,Lin WH,Chen GY,Wu CH*. Ethanolic extract of Vitis thunbergii exhibits lipid lowering properties via modulation of the AMPK-ACC pathway in hypercholesterolemic rabbits . Evidence-Based Complementary and Alternative Medicine .2012 ;(2012):436786

26. 2012 Huang GJ,Pan CH,Liu FC,Wu TS,Wu CH*. Anti-inflammatory effects of ethanolic extract of Antrodia salmonea in the lipopolysaccharide-stimulated RAW246.7 macrophages and the λ-carrageenan-induced paw edema model . Food and chemical toxicology .2012 ;(50):1485-1493

27. 2012 Huang GJ,Pan CH,Wu CH*. Sclareol Exhibits Anti-inflammatory Activity in both Lipopolysaccharide-stimulated Macrophages and the λ-Carrageenan-induced Paw Edema Model . Journal of Natural Products .2012 ;(75):54-59

28. 2012 Pan CH,Chen CW,Sheu MJ,Wu CH*. Salvianolic acid B inhibit SDF-1α-stimulated cell proliferation and migration of vascular smooth muscle cells by suppressing CXCR4 receptor . Vascular Pharmacology .2012 ;(56):98-105

29. 2012 Wang HH,Pan CH,Wu PP,Luo SF,Lin HJ,Wu CH*. Alteration of the Tongue Manifestation Reflects Clinical Outcomes of Peptic Ulcer Disease . Journal of Alternative and Complementary Medicine .2012 ;(18):1038-1044

30. 2012 Huang GJ,Deng JS,Chiu CS,Liao JC,Hsieh WT,Sheu MJ, Wu CH*. Hispolon Protects against Acute Liver Damage in the Rat by Inhibiting Lipid Peroxidation, Proinflammatory Cytokine, and Oxidative Stress and Downregulating the Expressions of iNOS, COX-2, and MMP-9 . Evidence-Based Complementary and Alternative Medicine .2012 ;(2012):480714

31. 2011 Huang GJ*,Lu TL,Chiu CS,Chen HJ,Wu CH,Lin YC, Hsieh WT, Liao JC, Sheu MJ, Lin YH*. Sweet potato storage root defensin and its tryptic hydrolysates exhibited angiotensin converting enzyme inhibitory activity in vitro . Botanical Studies .2011 ;(52):257-264

32. 2011 Chen PY,Hsu WT,Jhuo MD,Ou CY,Cheng TH,Shih TC, Wu CH, Wu RSC, Hsia TC, Chung JG*. Computational analysis of de novo evolution of hepatitis C virus NS5B polymerase inhibitors . In Vivo .2011 ;(25):219-228

33. 2011 Huang MH,Huang SS,Wang BS,Wu CH,Sheu MJ,Hou WC, Lin SS, Huang GJ*. Antioxidant and anti-inflammatory properties of Cardiospermum halicacabum and its reference compounds ex vivo and in vivo . Journal of Ethnopharmacology .2011 ;(133):743-750

34. 2011 Wu RSC,Huang CC,Pan CH,Wu KC,Chen CC,Liu SK, Tang CL, Wu CH*. Total sleep deprivation augments balloon angioplasty-induced neointimal hyperplasia in rats . Experimental Physiology .2011 ;(96):239-1247

35. 2011 Wang YJ,Chien YC,Wu CH,Liu DM*. Magnolol-Loaded Core–Shell Hydrogel Nanoparticles: Drug Release, Intracellular Uptake, and Controlled Cytotoxicity for the Inhibition of Migration of Vascular Smooth Muscle Cells . Molecular Pharmaceutic .2011 ;(8):2339-2349

36. 2011 Chang TM,Shi GY,Wu HL,Wu CH,Su YD,Wang HL, Wen HY, Huang HC*. Effects of Salvianolic Acid B on Protein Expression in Human Umbilical Vein Endothelial Cells . Evidence-based Complementary and Alternative Medicine .2011 ;(2011):213050

37. 2011 Chou PY,Huang GJ,Pan CH,Chien YC,Chen YY,Wu CH, Sheu MJ, Cheng HC*. Trilinolein inhibits proliferation of human non-small cell lung carcinoma A549 through the modulation of PI3K/Akt pathway . American Journal of Chinese Medicine .2011 ;(39):803-815

38. 2010 Kuo WW,Weng JR,Huang CY,Tsai CH,Liu WH,Wen CH, Tsai SC, Wu CH*. Exploring the molecular mechanisms of OSU-03012 on vascular smooth muscle cell proliferation . Molecular and Cellular Biochemistry .2010 ;(344):81-89

39. 2010 Pan CH,Hsieh IC,Liu FC,Hsieh WT,Sheu MJ,Koizumi A, Wu CH*. Effects of a Chinese Herbal Health Formula, “Gan-Lu-Yin”, on Angiogenesis . Journal of Agriculture and Food Chemistry .2010 ;(58):7685-7692

40. 2010 Sheu MJ,Chou PY,Huang CS,Tsai IC,Chien YC,Lin SY, Tsai HY, Cheng HC, Wu CH*. Pipoxolan inhibits proliferation of HL-60 human leukemia cancer cells by arresting the cell cycle at the G0/G1 phase . Clinical and Experimental Pharmacological and Physiology .2010 ;(37):605-612

41. 2010 Chen PY*,Jhuo MD,Lai MC,Lin JG,Kuo YH,Kao CS, Shih TC, Wu CH. Organism Specific BlAST Web-Based Search Engine - A Framework of Nucleotide Similarity Analysis . Biomedical Engineering-Applications Basis Communications .2010 ;(22):47-52

42. 2010 Chou PY,Huang GJ,Cheng HC,Wu CH,Chien YC,Chen JS, Huang MH, Hsu KJ, Sheu MJ*. Analgesic and Anti-inflammatory Activities of an Ethanol Extract of Dunaliella Salina Teod. (Chlorophyceae) . Journal of Food Biochemistry .2010 ;(34):1288-1302

43. 2010 Huang GJ,Chiu CS,Wu CH,Huang SS,Amegaya S,Hou WC, Sheu MJ, Liao JC, Chen YC, Lin YH*. Redox status of Bowman-Birk inhibitor from soybean influence its in vitro antioxidant activities . Botanical Studies .2010 ;(51):431-437

44. 2010 Huang GJ,Lu TL,Chiu CS,Chen HJ,Wu CH,Lin YC, Hsieh WT, Liao JC, Sheu MJ, Lin YH*. Sweet potato storage root thioredoxin h2 and their peptic hydrolysates exhibited angiotensin converting enzyme inhibitory activity in vitro . Botanical Studies .2010 ;(52):15-22

45. 2009 Lu TL,Huang GJ,Lu TJ,Wu JB,Wu CH,Yang TC, Iizuka A, Chen YF*. Hispolon from Phellinus linteus Has Antiproliferative Effects via MDM2-recruited ERK1/2 Activity in Breast and Bladder Cancer Cells . Food and Chemical Toxicology .2009 ;(47):2013-2021

46. 2009 Cheng YC,Kuo WW,Wu CH,Shu WT,Kuo CH,Hwang JM, Hsu HH, Chen LM, Huang CY, Lee SD*. Iron status and cardiovascular risk factors in patients with haemodialysis versus patients with ischaemic heart disease . Nephrology .2009 ;(14):65-69

47. 2009 Way TD,Lin HY,Kuo DH,Tsai SJ,Shieh JC,Wu CH, Lee MR, Lin JK*. Pu-erh Tea Attenuates Hyperlipogenesis and Induces Hepatoma Cells Growth Arrest through Activating AMPK in Human HepG2 Cells . Journal of Agricultural and Food Chemistry .2009 ;(57):5257-5264

48. 2009 Sheu MJ,Chou PY,Cheng HC,Wu CH,Huang GJ,Wang BS, Chen JS, Chien YC, Huang MH. Analgesic and Anti-inflammatory Activities of a water extract of Trachelospermum jasminoides . Journal of Ethnopharmacology .2009 ;(126):332-338

49. 2008 Chao HH*,Liu JC,Lin JW,Chen CH,Wu CH,Cheng TH. Uric acid stimulates endothelin-1 gene expression associated with NADPH oxidase in human aortic smooth muscle cells . Acta Pharmacologica Sinica .2008 ;(29):1301-1312

50. 2008 Sheu MJ,Huang GJ,Wu CH,Chen JS,Chang HY,Chang SJ, Chung JG*. Ethanol extract of Dunaliella salina induces cell cycle arrest and apoptosis in A549 Human non-small cell lung cancer cells . In vivo .2008 ;(22):369-378

51. 2008 Chen CYC§,Wu CH§. Magnolol Encapsulated by Liposome in Inhibiting Smooth Muscle Cell Proliferation . Journal of the Chinese Chemical Society .2008 ;(55):517-521

52. 2008 Chen CYC§,Chen YF§,Wu CH§,Tsai HY. What is the Effective Component in Suanzaoren Decoction for Curing Insomnia? Discovery by Virtual Screening and Molecular Dynamic Simulation . Journal of Biomolecular Structure and Dynamics .2008 ;(26):57-64

53. 2008 Hwang JM,Weng YJ,Lin JA,Bau DT,Ko FY,Tsai FJ, Tsai CH, Wu CH, Lin PC, Huang CY, Kuo WW*. Hypoxia-induced compensatory effect as related to Shh and HIF-1 alpha in ischemia embryo rat heart . Molecular and Cellular Biochemistry .2008 ;(311):178-187

54. 2008 Hsu YM,Lai CH,Chang CY,Fan CT,Chen CT,Wu CH*. Characterizing the Lipid-lowering Effects and Antioxidant Mechanisms of Tomato Pastes . Bioscience Biotechnology and Biochemistry .2008 ;(72):677-685

55. 2007 Chao HH,Hong HJ,Liu JC,Lin JW,Chen YL,Chiu WT, Wu CH, Shyu KG, Cheng TH. Leptin stimulates endothelin-1 expression via extracellular signal-regulated kinase by epidermal growth factor receptor transactivation in rat aortic smooth muscle cells . European Journal of Pharmacology .2007 ;(573):49-54

56. 2007 Chen YC*,Chang CH,Yang YM,Maa JR,Lin JL,Wu CH. Interaction of dipalmitoyl phosphatidylcholine with n-hexadecanol in monolayer and liposome . Journal of the Chinese Chemical Society .2007 ;(54):317-322

研究計畫

計畫名稱
108 109年度「生醫產業與新農業跨領域人才培育計畫」之B類「生醫產業與新農業創新創業人才培育計畫」
補助單位
教育部

計畫名稱
108 生醫與醫材轉譯加值人才培訓-ANCHOR UNIVERSITY計畫(TMU)
補助單位
科技部

計畫名稱
108 Kruppel-like Factor 2為標的之介入策略應用於非小細胞肺癌治療的功效評估與機制探討(1/3)
補助單位
科技部

計畫名稱
107 108年度「生醫產業與新農業跨領域人才培育計畫」之B類「生醫產業與新農業創新創業人才培育計畫」
補助單位
教育部

計畫名稱
107 生醫與醫材轉譯加值人才培訓-ANCHOR UNIVERSITY計畫(TMU)
補助單位
科技部

計畫名稱
107 開發海芙蓉作?改善血管再阻塞藥物之可行性評估及其藥理機轉之探討
補助單位
科技部

計畫名稱
106 107年度「生醫產業與新農業跨領域人才培育計畫」之B類「生醫產業與新農業創新創業人才培育計畫」
補助單位
教育部

計畫名稱
106 「107年度馬祖地區農特產品發表計畫」委託專業服務
補助單位
連江縣政府

計畫名稱
106 生醫與醫材轉譯加值人才培訓- ANCHOR UNIVERSITY計畫
補助單位
科技部

計畫名稱
105 SSRI藥物Paroxetine調控心血管平滑肌細胞增生與遷移之藥理影響與機制探討
補助單位
科技部

計畫名稱
105 「深層海水濃縮礦物質液」健康食品功效研究計劃案
補助單位
台灣海洋深層水股份有限公司

計畫名稱
105 HTC藥典合作計畫
補助單位
宏達國際電子股份有限公司

計畫名稱
105 牛樟芝預防粥狀動脈硬化之功效評估研究計畫
補助單位
吉亞生物科技有限公司

計畫名稱
105 社區健康促進的新解方:人文社會x健康管理+黑客松x參與式預算
補助單位
教育部

計畫名稱
105 老化對血管再阻塞形成的研究:建構具抑制血小板衍生生長因子乙型受體之藥物標的篩選平台
補助單位

計畫名稱
104 養生飲之降血脂與不易形成體脂肪功能功效評估和安定性試驗研究計畫
補助單位
友華生技醫藥股份有限公司

計畫名稱
104 台肥產業技術提升研究諮詢計畫
補助單位
台灣肥料股份有限公司

計畫名稱
104 探討ApoE於肺癌中之病理角色與早期預後指標之應用評估
補助單位
科技部

計畫名稱
104 赴美國聖地牙哥參加生物醫學年會-陳詩茵
補助單位
科技部

計畫名稱
104 赴美國聖地牙哥參加2016EB生醫年會-陳昌蕊
補助單位
科技部

計畫名稱
104 赴美國聖地牙哥參加2016實驗生物年會-王婕伃
補助單位
科技部

計畫名稱
103 血管支架再阻塞患者基因性生物標誌的鑑定與病理研究
補助單位
臺北醫學大學附設醫院

計畫名稱
103 台肥產業技術提升研究諮詢計畫
補助單位
台灣肥料股份有限公司

計畫名稱
103 103年度「國際中醫藥產業發展趨勢探討與對策研析」
補助單位
衛生福利部

計畫名稱
103 香紫蘇醇應用於Cisplatin抗藥性非小細胞肺癌的輔助性治療之臨床前評估
補助單位
科技部

計畫名稱
103 單胺氧化酶(MAO)於血管內膜增生中之病理角色與機制探討
補助單位
科技部

計畫名稱
103 台肥產業技術提升研究諮詢計畫
補助單位
台灣肥料股份有限公司

計畫名稱
102 TMU102-AE1-B15
補助單位
學校

計畫名稱
102 台肥產業技術提升研究諮詢計畫
補助單位
台灣肥料股份有限公司