吳駿翃(Wu, Alexander Jun-Hong) 副教授

現   職
轉譯醫學博士學位學程 副教授


學 歷

皇后大學解剖及細胞生物學 博士
皇后大學生化 學士




2020/05/01 ~
2019/11/01 ~
2014/11/19 ~ 2017/07/31
2014/08/01 ~ 2014/11/18


Ottana Health Research Institute博士後研究員


Bioluminescence imaging IVIS 200 system 活體影像造影
Western blotting, immunohistochemistry
Molecular cloning
Cell culture
Small animal experimentation 小鼠實驗
small animal bone marrow transplation
gene modifications - transfection, infection
flow cytometry
real-time PCR
Patient-derived xenograft model establishment



1. 2021 Pharmacoinformatics and Preclinical Studies of NSC765690 and NSC765599, Potential STAT3/CDK2/4/6 Inhibitors with Antitumor Activities against NCI60 Human Tumor Cell Lines . biomedicines .2021 ;(9):1-22

2. 2021 Multi-Omics Data Analysis of Gene Expressions and Alterations, Cancer-Associated Fibroblast and Immune Infiltrations, Reveals the Onco-Immune Prognostic Relevance of STAT3/CDK2/4/6 in Human Malignancies . Cancers .2021 ;(13):1-26

3. 2020 Ovatodiolide, isolated from Anisomeles indica, suppresses bladder carcinogenesis through suppression of mTOR/β-catenin/CDK6 and exosomal miR-21 derived from M2 tumor-associated macrophages . Toxicol Appl Pharmacol . .2020

4. 2020 Preclinical investigation of ovatodiolide as a potential inhibitor of colon cancer stem cells via downregulating sphere-derived exosomal β-catenin/STAT3/miR-1246 cargoes . Am J Cancer Res .2020 ;(1):2237-2354

5. 2020 HNC0014, a Multi-Targeted Small-Molecule, Inhibits Head and Neck Squamous Cell Carcinoma by Suppressing c-Met/STAT3/CD44/PD-L1 Oncoimmune Signature and Eliciting Antitumor Immune Responses . Cancers .2020 ;(12):1-18

6. 2019 ATP Synthase Subunit Epsilon Overexpression Promotes Metastasis by Modulating AMPK Signaling to Induce Epithelial-to-Mesenchymal Transition and Is a Poor Prognostic Marker in Colorectal Cancer Patients . J. Clin. Med .2019 ;(8):1070-1083

7. 2019 In silico identification of thiostrepton as an inhibitor of cancer stem cell growth and an enhancer for chemotherapy in non-small-cell lung cancer . J Cell Mol Med. .2019 ;(8):1-13

8. 2019 The Development and Applications of a Dual Optical Imaging System for Studying Glioma Stem Cells . Mol Imaging .2019 ;(18):1-13

9. 2019 Ovatodiolide Suppresses Oral Cancer Malignancy by Down-Regulating Exosomal Mir-21/STAT3/β-Catenin Cargo and Preventing Oncogenic Transformation of Normal Gingival Fibroblasts . Cancers .2019 ;(12):1-16

10. 2019 Wen YT,Wu AT,Bamodu OA,Wei Li,Lin CM,Yen Y, Chao TY, Mukhopadhyay D, Hsiao M, Huang HS. A Novel Multi-Target Small Molecule, LCC-09, Inhibits Stemness and Therapy-Resistant Phenotypes of Glioblastoma Cells by Increasing miR-34a and Deregulating the DRD4/Akt/mTOR Signaling Axis . Cancers .2019 ;(11):1-18

11. 2018 Destruxin B Suppresses Drug-Resistant Colon Tumorigenesis and Stemness Is Associated with the Upregulation of miR-214 and Downregulation of mTOR/β-Catenin Pathway . Cancers .2018 ;(10):1-10

12. 2018 Chen JH,Wu A TH,Tzeng D TW,Huang CC,Tzeng YM,Chao TY. Antrocin, a bioactive component from Antrodia cinnamomea, suppresses breast carcinogenesis and stemness via downregulation of β-catenin/Notch1/Akt signaling . phytomedicine .2018 ;(52):70-78

13. 2018 Intensity-modulated radiotherapy with systemic chemotherapy improves survival in patients with nonmetastatic unresectable pancreatic adenocarcinoma: A propensity score-matched, nationwide, population-based cohort study. . Radiother Oncol .2018 ;(129):326-332

14. 2017 Hung YW, Wang WC, Chu CY, Hung CL, Changou CA, Yen Y, Kung HJ. Long noncoding RNA LncHIFCAR/MIR31HG is a HIF-1α co-activator driving oral cancer progressio . Nature communications .2017 ;(22):15874-15890

15. 2017 Feedback regulation of ALDOA activates the HIF-1α/MMP9 axis to promote lung cancer progression . Cancer Letter .2017 ;(403):28-36

16. 2017 Huang TH,Wu SY,Huang YJ,Wei PL,Wu AT(,Chao TY. The identification and validation of Trichosstatin A as a potential inhibitor of colon tumorigenesis and colon cancer stem-like cells . Am J Cancer Res .2017 ;(7):1227-1237

17. 2017 Chang YC,Chi LH,Chang WM,Su CY,Lin YF,Chen CL, Chen MH, Chang PM, Wu AT, Hsiao M. Glucose transporter 4 promotes head and neck squamous cell carcinoma metastasis through the TRIM24-DDX58 axis . Journal of hematology and oncology .2017 ;(10):0-0

18. 2017 Huang YJ,Yang CK,Wei PL,Huynh TT,Whang-Peng J,Meng TC, Hsiao M, Tzeng YM, Wu AT, Yen Y. Ovatodiolide suppresses colon tumorigenesis and prevents polarization of M2 tumor-associated macrophages through YAP oncogenic pathways . Journal of Hematology and Oncology .2017 ;(10):0-0

19. 2016 Su YH,Huang WC,Huang TH,Huang YJ,Sue YK,Huynh TT, Hsiao M, Liu TZ, Wu ATH, Lin CM. Folate deficient tumor microenvironment promotes epithelial-to-mesenchymal transition and cancer stem-like phenotypes . Oncotarget .2016 ;(0):0-0

20. 2016 Wei Li,Su YK,Lin CM,Chao TY,Huang SP,Huynh TT, Jan HJ, Whang-Peng, Chiou JF, Wu AT, Hsiao M. Preclinical investigation of ibrutinib, a Bruton's kinase tyrosine (Btk) inhibitor, in suppressing glioma tumorigenesis and stem cell phenotypes . Oncotarget .2016 ;(0):0-0

21. 2016 Hsiao YW,Lai TC,Lin YH,Su CY,Lee JJ,Liao AT, Lin YF, Hsieh SC, Wu AT, Hsiao M. Granulysin expressed in a humanized mouse model induces apoptotic cell death and suppresses tumorigenicity. . Oncotarget .2016 ;(0):0-0

22. 2015 Lin CS,Lin YC,Adebayo BO,Wu A,Chen JH,Peng YJ, Cheng MF, Lee WH, Hsiao M, Chao TY, Yeh CT. Silencing JARID1B suppresses oncogenicity, stemness and increases radiation sensitivity in human oral carcinoma . Cancer Lett .2015 ;(368):36-45

23. 2015 Chang TC,Yeh CT,Adebayo BO,Lin YC,Deng L,Rao YK, Huang CC, Lee WH, Wu AT, Hsiao M, Wu CH, Wa. 4-Acetylantroquinonol B inhibits colorectal cancer tumorigenesis and suppresses cancer stem-like phenotype . Toxicol Appl Pharmacol. .2015 ;(288):258-268

24. 2015 Huang CC,Lin CM,Huang YJ,Wei L,Ting LL,Kuo CC, Hsu C, JFC, Wu AT, Lee WH.. Garcinol downregulates Notch1 signaling via modulating miR-200c and suppresses oncogenic properties of PANC-1 cancer stem-like cells . Biotechnol Appl Biochem. .2015 ;(0):0-0

25. 2015 Bamodu OA,Huang WC,Tzeng DT,Wu A,Wang LS,Yeh CT, Chao TY. Ovatodiolide sensitizes aggressive breast cancer cells to doxorubicin, eliminates their cancer stem cell-like phenotype, and reduces doxorubicin-associated toxicity. . Cancer Letter .2015 ;(364):125-134

26. 2015 Su CM,Lee WH,Wu AT,Lin YK,Wang LS,Wu CH, Yeh CT. Pterostilbene inhibits triple-negative breast cancer metastasis via inducing microRNA-205 expression and negatively modulates epithelial-to-mesenchymal transition . J Nutr Biochem .2015 ;(26):675-685

27. 2015 Zucha MA,Wu AT,Lee WH,Wang LS,Lin WW,Yuan CC, Yeh CT. Bruton's tyrosine kinase (Btk) inhibitor ibrutinib suppresses stem-like traits in ovarian cancer . Oncotarget .2015 ;(6):13255-13268

28. 2015 Huynh TT,Lin CM,Lee WH,Wu AT,Lin YK,Lin YF, Yeh CT, Wang LS. Pterostilbene suppressed irradiation-resistant glioma stem cells by modulating GRP78/miR-205 axis . J Nutr Biochem .2015 ;(26):466-475

29. 2014 Huynh TT,Rao YK,Lee WH,Chen HA,Le TD,Tzeng DT, Wang LS, Wu AT, Lin YF, Tzeng YM, Yeh CT. Destruxin B inhibits hepatocellular carcinoma cell growth through modulation of the Wnt/B-catenin signaling pathway and epithelial-mesenchymal transition . Toxicol in Vitro .2014 ;(28):552-561

30. 2013 Mak KK, Wu ATH,Lee WH,Chang TC,Chiou JF,Wang LS,Wu CH, Huang CYF, Shieh YS, Chao TY, Ho CT, Yen GC, Yeh CT. Pterostilbene, a bioactive component of blueberries, suppresses the generation of breast cancer stem cells within tumor microenvironment and metastasis via modulating NF-κB/microRNA448 circuit. . Mol Nutr Food Res. .2013 ;(0):0-0

31. 2013 Yeh CT, Su CL,Huang CY,Lin JKY,Lee WH,Chang PMH,Kuo YL, Liu YW, Wang LS, Wu CH, Shieh YS, Jan YH, Chuang YJ, Hsiao M, Wu ATH. A preclinical evaluation of antimycin A as a potential anti-lung cancer stem cell agent. . Evidence-Based Complementary and Alternative Medicine .2013 ;(0):0-0

32. 2013 Lee CM, Wu ATH,Su YH,Lee WH,Chiou JF,Lin YK,Hsiao M, Wu CH, Yeh CT. Blue berry isolate, Pterostilbene, functions as a potential anti-cancer stem cell agent in suppressing irradiation-mediated enrichment of hepatoma stem cells. . Evidence-Based Complementary and Alternative Medicine .2013 ;(0):0-0

33. 2012 Yeh CT,Rao YK,Ye M,Wu WS,Chang TC,Wang LS, Wu CH, Wu AT, Tzeng YM. Preclinical evaluation of destruxin B as a novel Wnt signaling target suppressing proliferation and metastasis of colorectal cancer using non-invasive bioluminescence imaging . Toxicol Appl Pharmacol .2012 ;(0):0-0

34. 2012 Lu HY, Chiou JF,Wu ATH,Tsai CY,Leu JD,Ting LL,Wang MF, Chen HY, Lin CT, Williams DF, Deng WP. The Effect of Diminished Osteogenic Signals on Reduced Osteoporosis Recovery in Aged Mice and . Biomaterials .2012 ;(0):0-0

35. 2012 Lin LC, Yeh CT,Kuo CC,Lee CM,Yen GC,Wang LS,Wu CH, Yang WC, Wu ATH. Sulforaphane Potentiates the Efficacy of Imatinib against Chronic Leukemia Cancer . J Agric Food .2012 ;(60):7031-7039

36. 2012 Cheng PW,Wu AT,Lu PJ,Yang YC,Ho WY,Lin HC, Hsiao M, Tseng CJ. Modulation of Central Control of Hypotensive Effects by Neuropeptide Y is Mediated through RSK Induced Activation of Endothelial Nitric Oxide Synthase . British Journal of Pharmacology .2012 ;(167):1148-1160

37. 2012 Yeh CT, Wu AT,Chang PM,Chen KY,Yang CN,Ho CC,Chen CC, Kuo YL, Lee PY, Liu YW, Yen CC, Hsiao M, Lu PJ, Lai JM, Wang LS, Wu CH, Chiou JF, Yang PC,. Trifluoperazine, an Antipsychotic Agent, Inhibits Cancer Stem Cell . Am J Respir Crit Care Med. .2012 ;(0):0-0

38. 2012 Liu YP,Yang CJ,Hung MS,Yeh CT,Wu AT,Lee YC, Lai TC, Lee CH, Hsiao YW, Lu. Cisplatin selects for multidrug-resistant CD133+ . Cisplatin selects for multidrug-resistant CD133+ .2012 ;(0):0-0

39. 2011 Liu HY,Wu ATH,Tsai CY,Chou KR,Zeng R,Wang MF, Chang WC, Hwang SM, Su CH, Deng WP. The Balance between Adipogenesis and Osteogenesis in Bone Regeneration by Platelet–Rich Plasma for Age-related Osteoporosis . Biomaterials .2011 ;(0):0-0

40. 2011 wei hj, wu at,hsu ch,lin hp,cheng wf,su ch,chiu wt,whang-peng j, douglas fl, deng wp. The Development of a Novel Cancer Immunotherapeutic Platform Using Tumor-targeting Mesenchymal Stem Cells and a Protein Vaccine . molecular therapy .2011 ;(19):2249-2257

41. 2011 Chiou JF, Wu AT,Wang WT,Kuo TH,Gelovani JG,Lin IH,Wu CH, Chiu WT, Deng WP. A Preclinical Evaluation of Antrodia Camphorata Alcohol Extracts in the Treatment of Non-Small Cell Lung Cancer Using Non-Invasive Molecular Imaging . Evid Based Complement Alternat Med .2011 ;(0):0-0

42. 2010 Tai CR,Wu AT,Chiou JF,Jan HJ,Wei HJ,Hsu CH, Lin CT, Chiu WT, Wu CW, Lee HM, Deng WP. The investigation of mitogen-activated protein kinase phosphatase-1 as a potential pharmacological target in non-small cell lung carcinomas, assisted by non-invasive molecular imaging . BMC Cancer .2010

43. 2010 Rao YK,Wu AT,Geethangili M,Huang MT,Chao WJ,Wu CH, Deng WP, Yeh CT, Tzeng YM. Identification of Antrocin from Antrodia camphorata as a Selective and Novel . Chemical Research in Toxicology .2010

44. 2010 Tung JN,Chen YW,Hsu CH,Liu TZ,Hsieh PY,Ting LL, Ko HL, Chang YJ, Chiou JF, Wu AT. Normoxically Overexpressed Hypoxia Inducible Factor 1-alpha is Involved in Arsenic Trioxide Resistance Acquisition in Hepatocellular Carcinoma. . annals of surgical oncology .2010

45. 2009 Chen WH,Lai MT,Wu ATH,Wu CC,Gelovani JG,Lin CT, Hung SC, Chiu WT, Deng WP. In Vitro Stage-Specific Chondrogenesis of Mesenchymal Stem Cells Committed to Chondrocytes . Arthritis Rheum-US .2009 ;(60):450-459

46. 2008 Anupriwan A,Schenk M,Kongmanas K,Vanichviriyakit R,Santos DC,Yaghoubian A, Liu F, Wu A, Berger T, Faull KF, Saitongdee P, Sretarugsa P, Tanphaichitr N. Presence of Arylsulfatase A and Sulfogalactosylglycerolipid in Mouse Ovaries: Localization to the Corpus Luteum . Endocrinology .2008 ;(149):3942-3951

47. 2008 Lo WC,Hsu CH,Wu AT,Yang LY,Chen WH,Chiu WT, Lai WF, Wu CH, Gelovani JG, Deng WP. A novel cell-based therapy for contusion spinal cord injury using GDNF-delivering NIH3T3 cells with dual reporter genes monitored by molecular imaging . J Nucl Med .2008 ;(49):1512-1519

48. 2007 Wu AT,Sutovsky P,Xu W,van der Spoel AC,Platt FM,Oko R. The postacrosomal assembly of sperm head protein, PAWP, is independent of acrosome formation and dependent on microtubular manchette transport . Dev Biol .2007 ;(312):471-483

49. 2007 Wu A,Anupriwan A,Iamsaard S,Charkrabandhu K,Santos DC,Rupar T, Tsang BK, Carmona E, Tanphaichitr N. Sperm surface arylsulfatase A can disperse the cumulus matrix of cumulus oocyte complexes . J Cell Physiol .2007 ;(213):201-211

50. 2007 Wu AT,Sutovsky P,Manandhar G,Xu W,Katayama M,Day BN, Park KW, Yi YJ, Xi YW, Prather RS, Oko R. PAWP, a sperm-specific WW domain-binding protein, promotes meiotic resumption and pronuclear development during fertilization . J Biol Chem .2007 ;(282):12164-12175

51. 2003 Sutovsky P,Manandhar G,Wu A,Oko R. Interactions of sperm perinuclear theca with the oocyte: implications for oocyte activation, anti-polyspermy defense, and assisted reproduction . Microsc Res Tech .2003 ;(61):362-378

1. 2005 Wu A,Sutovsky P,Manandhar G,Katayama M,Day BN,Prather RS, Oko R. The involvement of a sperm specific WW domain binding protein in pronuclear formation during mammalian fertilization . XVIII North American Testis Workshop, Seattle, Washington, USA .2005

2. 2005 Wu A,Sutovsky P,Oko R. The postacrosomal assembly of sperm head protein, PAWP, is independent of acrosome formation and dependent on microtubular manchette transport . 38th Annual meeting, Society for the study of reproduction, Quebec City, Canada .2005

3. 2002 Mountjoy JR,Wu ATH,Oko R. A RAB2 variant (PT24) is a prominent component of the bull sperm perinuclear theca . Queen's university 5th annual meeting for basic and clinical research trainees faculty of health sciences .2002

4. 2002 Sutovsky P,Wu A,Park KW,Prather RS,Carter DB,Takahashi D, Dominko T, Sutovsky M, Oko R. PT32: sperm perinuclear theca protein with protperties of the sperm-borne oocyte activating factor . 35th annual meeting, Society for the study of reproduction, Baltimore MD, USA .2002

5. 2001 Wu A,Oko R. PT32. A potential candidate for sperm borne oocyte activating factor . 7th international congress of Andrology, Montreal Quebec, Canada .2001

6. 2001 Wu A,Oko R. A potential sperm borne oocyte activating factor or cofactor . Queen's University 4th Annual meeting for basic and clinical research trainees faculty of health sciences .2001

7. 2000 Oko R,Sutovsky P,Tovich R,Wu A. The composition and role of the sperm perinuclear theca . French-Czech-Slovak Colloquium, international conference of reproductive biology, Slovak Academy of Sciences at Stara Lesna .2000

8. 1999 Wu ATH,Oko R. The characterization of a novel 32 kDa sperm perinuclear theca protein . Queen's University 2nd Anuunal Meeting for basic and clinical research trainees faculty of health sciences .1999

9. 1999 Wu ATH,Oko R. The characterization of a novel 32kDa sperm perinuclear theaca protein . The 39th American Society for Cell biology annual meeting, Washington DC, USA .1999

10. 1998 Oko R,Aul R,Wu A. The identity and possible role of sperm perinuclear theca proteins . Candadian Federation of Biological Societies 41st Anuunal Meeting, Edmonton, Canada .1998

11. 1997 Lawson V,Wu TH,Schalles U,Oko R. The molecular cloning and developmental expression of two novel mRNAs encoding putative 14kDa ODF and FS proteins of the rat sperm tail . The American Society for Cell Biology, Washington D.C .1997

12. 1997 Gong J,Wu TH,Oko R. A novel testicular protein, with sequence similarities to WW domain binding protein, is the major component of the bull sperm subacrosomal layer . The American Society for Cell Biology, Washington D.C .1997


105 化學全合成牛樟芝天然物安卓幸(Antrocin)以及其衍生物抗癌機制實驗研究計畫

105 探討牛樟芝萃取物在提高肝臟對於酒精分解功能以及保護肝臟的生物機制之研究計畫

104 2016第二屆史丹佛-台灣 ALDH2基因與人類疾病研討會

103 臨床前FGFR抑制劑對於抗藥性胰臟癌療效之評估

103 BLCFA1對於抑制惡性三陰性乳癌轉移功效之研究

103 化學全合成牛樟芝天然物安卓幸(ANTROCIN)抗癌動物試驗研究計畫

103 探討BLCFA01在小鼠模式抗老話功能之研究

102 探討LncRNA MALAT1 在惡性乳癌幹細胞生成之角色以及pterostilbene 對於透過抑制MALAT1而抑制乳癌幹細胞功能之研究

102 BLCFA1對於抑制惡性腫瘤生長功效之研究

101 探討樟芝萃取物antrocin在抑制大直腸癌細胞轉移的效用及機制

101 應用分子造影模式探討蛋白疫苗結合幹細胞趨癌特性做為廣效性癌 症基因合併疫苗療法之臨床前研究評估

101 探討Hscube2對於抑制乳癌幹細胞的機制及以其作為新藥開發之潛能

100 探討氧化壓力在抗藥性乳癌幹細胞所扮演之角色及利用調控自由基藥物提高化療功效的可能性

100 探討以植物化學成分抑制β-catenin/PIN1訊息傳道路徑於肝癌幹細胞的發生

100 應用分子造影模式探討蛋白疫苗結合幹細胞趨癌特性做為廣效性癌 症基因合併疫苗療法之臨床前研究評估

100 探討Hscube2對於抑制乳癌幹細胞的機制及以其作為新藥開發之潛能

99 應用分子造影模式探討蛋白疫苗結合幹細胞趨癌特性做為廣效性癌 症基因合併疫苗療法之臨床前研究評估

98 葉酸缺乏引發之氧化/氮化壓力在調控肝癌SK-Hep-1細胞的轉移傾向所扮演之角色

97 應用分子造影模式探討基因及細胞治療方法於非小細胞肺癌動物模式的研究