李宜達(Lee, I-Ta) 助理教授

Email
itlee0128@tmu.edu.tw
現   職
牙醫學系 助理教授

學經歷

學 歷

畢業學校與學位[修業時間]
長庚大學生物醫學研究所生理暨藥理學組 博士
2005/09~2010/06
國立陽明大學解剖學暨細胞生物學研究所 碩士
2003/09~2005/06
輔仁大學生命科學系 學士
1999/09~2003/06

本校學術經歷

任職單位與職稱[起迄時間]
牙醫學系助理教授
2019/03/08~

本校兼職教學行政經歷

服務單位與職稱[起迄時間]
無資料!

其它經歷

任職單位與職稱[起迄時間]
弘光科技大學護理系(所)兼任助理教授
2018/08/01~2019/01/31
臺中榮民總醫院醫學研究部博士後研究員
2018/01/01~2019/03/07
中國醫藥大學生物醫學研究所分子化學暨細胞生物學組合聘助理教授
2015/12~2017/10/06
中國醫藥大學醫學系解剖學科專任助理教授
2014/10/01~2017/10/06
長庚大學醫學系生理暨藥理學科博士後研究員
2013/09/06~2014/06/30
林口長庚醫院麻醉科博士後研究員
2012/08/01~2013/09/05
長庚大學醫學系麻醉科博士後研究員
2011/08/01~2012/07/31

專長與研究領域

學門領域
藥理及毒理
Pharmacology and Toxicology
細胞生物及解剖
Cell Biology and Anatomy
學術專長
細胞及分子生物學
細胞及分子生物學
細胞訊息傳遞學
細胞訊息傳遞學
氧化與抗氧化醫學
氧化與抗氧化醫學
抗發炎
抗發炎
口腔胚胎組織學
口腔胚胎組織學
口腔解剖
口腔解剖

論文著作

清冊下載


1. 2020 Lee CW,Su YH,Chiang YC,Lee IT,Li SY,Lee HC, Hsu LF, Yan YL, Li HY, Chen MC, Peng KT, Lai CH. Glycofullerenes inhibit particulate matter induced inflammation and loss of barrier proteins in HaCaT human keratinocytes . Biomolecules .2020 ;(10):514

2. 2020 Tsai MH,Chi MC,Hsu JF,Lee IT,Lin KM,Fang ML, Lee MH, Lee CW, Liu JF . Urban particulate matter enhances ROS/IL-6/COX-II production by inhibiting MicroRNA-137 in synovial fibroblast of rheumatoid arthritis . Cells .2020 ;(9):1378

3. 2020 Cheng CY,Vo TTT,Lin WN,Huang HW,Chuang CC,Chu PM, Lee IT. Nrf2/HO-1 partially regulates cytoprotective effects of carbon monoxide against urban particulate matter-induced inflammatory responses in oral keratinocytes . Cytokine .2020 ;(133):155185

4. 2019 Lee CW,Chi MC,Hsu LF,Yang CM,Hsu TH,Chuang CC, Lin WN, Chu PM, Lee IT. Carbon monoxide releasing molecule-2 protects against particulate matter-induced lung inflammation by inhibiting TLR2 and 4/ROS/NLRP3 inflammasome activation . Molecular Immunology .2019 ;(112):163-174

5. 2019 Lee CW,Chi MC,Peng KT,Chiang YC,Hsu LF,Yan YL, Li HY, Chen MC, Lee IT, Lai CH. Water-soluble fullerenol C60(OH)36 toward effective anti-air pollution induced by urban particulate matter in HaCaT cell . International Journal of Molecular Sciences .2019 ;(20):4259-4278

6. 2019 Chang JF,Yeh JC,Ho CT,Liu SH,Hsieh CY,Wang TM, Chang SW, Lee IT, Huang KY, Wang JY, Lin WN . Targeting ROS and cPLA2/COX2 expressions ameliorated renal damage in obese mice with endotoxemia . International Journal of Molecular Sciences .2019 ;(20):4393

7. 2019 Hsu PS,Lin CM,Chang JF,Wu CS,Sia KC,Lee IT, Huang KY, Lin WN. Participation of NADPH oxidase-related reactive oxygen species in leptin-promoted pulmonary inflammation: regulation of cPLA2alpha and COX-2 expression . International Journal of Molecular Sciences .2019 ;(20):1078

8. 2019 Lee IT,Lin CF,Huang YL,Chong KY,Hsieh MF,Huang TH, Cheng CY. Protective mechanisms of resveratrol derivatives against TNF-alpha-induced inflammatory responses in rat mesangial cells . Cytokine .2019 ;(113):380-392

9. 2018 Lee IT,Lin CC,Yang CC,Hsiao LD,Wu MY,Yang CM. Resveratrol attenuates Staphylococcus aureus-induced monocyte adhesion through downregulating PDGFR/AP-1 activation in human lung epithelial cells . International Journal of Molecular Sciences .2018 ;(19):3058-3073

10. 2018 Tsai MH,Wu CH,Lin WN,Cheng CY,Chuang CC,Chang KT, Jiang RS, Hsu JF, Lee IT. Infection with Staphylococcus aureus elicits COX-2/PGE2/IL-6/MMP-9-dependent aorta inflammation via the inhibition of intracellular ROS production . Biomedicine & Pharmacotherapy .2018 ;(107):889-900

11. 2018 Tsai MH,Yang CM,Chang KT,Chuang CC,Lin WN,Jiang RS, Wu CH, Lee IT. Carbon monoxide ameliorates Staphylococcus aureus-elicited COX-2/IL-6/MMP-9-dependent human aortic endothelial cell migration and inflammatory responses . Immunology Letters .2018 ;(203):40-49

12. 2018 Lee CW,Wu CH,Chiang YC,Chen YL,Chang KT,Chuang CC, Lee IT. Carbon monoxide releasing molecule-2 attenuates Pseudomonas aeruginosa-induced ROS-dependent ICAM-1 expression in human pulmonary alveolar epithelial cells . Redox Biology .2018 ;(18):93-103

13. 2018 Lee CW,Hsu LF,Lee MH,Lee IT,Liu JF,Chiang YC, Tsai MH. Extracts of Artocarpus communis induce mitochondriaon-associated apoptosis via pro-oxidative activity in human glioblastoma cells . Frontiers in Pharmacology .2018 ;(9):411

14. 2018 Hsu JF,Lai MY,Lee CW,Chu SM,Wu IH,Huang HR, Lee IT, Chiang MC, Fu RH, Tsai MH. Comparison of the incidence, clinical features and outcomes of invasive candidiasis in children and neonates . BMC Infectious Diseases .2018 ;(18):194

15. 2017 Chiang MH,Liang CJ,Liu CW,Pan BJ,Chen WP,Yang YF, Lee IT, Tsai JS, Lee CW, Chen YL. Aliskiren improves ischemia- and oxygen glucose deprivation-induced cardiac injury through activation of autophagy and AMP-activated protein kinase . Frontiers in Pharmacology .2017 ;(8):819

16. 2017 Tsai MH,Hsu LF,Lee CW,Chiang YC,Lee MH,How JM, Wu CM, Huang CL, Lee IT. Resveratrol inhibits urban particulate matter-induced COX-2/PGE2 release in human fibroblast-like synoviocytes via the inhibition of activation of NADPH oxidase/ROS/NF-kappaB . International Journal of Biochemistry & Cell Biology .2017 ;(88):113-123

17. 2017 Liu CW,Sung HC,Lin SR,Wu CW,Lee CW,Lee IT, Yang YF, Yu IS, Lin SW, Chiang MH, Liang CJ, Chen YL. Resveratrol attenuates ICAM-1 expression and monocyte adhesiveness to TNF-alpha-treated endothelial cells: evidence for an anti-inflammatory cascade mediated by the miR-221/222/AMPK/p38/NF-kappaB pathway . Scientific Reports .2017 ;(7):44689

18. 2017 Lai MY,Hsu JF,Chu SM,Wu IH,Huang HR,Lin CC, Lee IT, Chiang MC, Fu RH, Tsai MH. Breakthrough candidemia in children: clinical and microbiological characteristics, therapeutic strategies and impact on outcomes . Future Microbiology .2017 ;(12):695-705

19. 2017 Tsai MH,Lee CW,Hsu LF,Li SY,Chiang YC,Lee MH, Chen CH, Liang HF, How JM, Chang PJ, Wu CM, Lee IT. CO-releasing molecules CORM2 attenuates angiotensin II-induced human aortic smooth muscle cell migration through inhibition of ROS/IL-6 generation and matrix metalloproteinases-9 expression . Redox Biology .2017 ;(12):377-388

20. 2017 Lee CW,Hu SC,Yen FL,Hsu LF,Lee IT,Lin ZC, Tsai MH, Huang CL, Liang CJ, Chiang YC. Magnolol nanoparticles exhibit improved water solubility and suppress TNF-alpha-induced VCAM-1 expression in endothelial cells . Journal of Biomedical Nanotechnology .2017 ;(13):255-268

21. 2016 Cho RL,Yang CC,Lee IT,Lin CC,Chi PL,Hsiao LD, Yang CM. Lipopolysaccharide induces ICAM-1 expression via a c-Src/NADPH oxidase/ROS-dependent NF-kappaB pathway in human pulmonary alveolar epithelial cells . American Journal of Physiology-Lung Cellular and Molecular Physiology .2016 ;(310):L639-L657

22. 2016 Hu SC,Lee IT,Yen MH,Lin CC,Lee CW,Yen FL. Anti-melanoma activity of Bupleurum chinense, Bupleurum kaoi and nanoparticle formulation of their major bioactive compound saikosaponin-d . Journal of Ethnopharmacology .2016 ;(179):432-442

23. 2016 Tsai MH,Lee CW,Chu SM,Lee IT,Lien R,Huang HR, Chiang MC, Fu RH, Hsu JF, Huang YC. Infectious complications and morbidities after neonatal bloodstream infections: An observational cohort study . Medicine .2016 ;(95):e3078

24. 2016 Tsai MH,Lee IT,Chu SM,Lien R,Huang HR,Chiang MC, Fu RH, Hsu JF, Huang YC. Clinical and molecular characteristics of neonatal extended-spectrum beta-lactamase-producing Gram-negative bacteremia: A 12-year case-control-control study of a referral center in Taiwan . PLOS ONE .2016 ;(11):e0159744

25. 2016 Lee CW,Lin ZC,Hu SC,Chiang YC,Hsu LF,Lin YC, Lee IT, Tsai MH, Fang JY. Urban particulate matter down-regulates filaggrin via COX2 expression/PGE2 production leading to skin barrier dysfunction . Scientific Reports .2016 ;(6):27995

26. 2016 Lee CW,Lin ZC,Hsu LF,Fang JY,Chiang YC,Tsai MH, Lee MH, Li SY, Hu SC, Lee IT, Yen FL. Eupafolin ameliorates COX-2 expression and PGE2 production in particulate pollutants-exposed human keratinocytes through ROS/MAPKs pathways . Journal of Ethnopharmacology .2016 ;(189):300-309

27. 2015 Hsu CK,Lee IT,Lin CC,Hsiao LD,Yang CM. Sphingosine-1-phosphate mediates COX-2 expression and PGE2 /IL-6 secretion via c-Src-dependent AP-1 activation . Journal of Cellular Physiology .2015 ;(230):702-715

28. 2015 Lee IT,Liu SW,Chi PL,Lin CC,Hsiao LD,Yang CM. TNF-alpha mediates PKCdelta/JNK1/2/c-Jun-dependent monocyte adhesion via ICAM-1 induction in human retinal pigment epithelial cells . PLOS ONE .2015 ;(10):e0117911-e0117924

29. 2015 Lin CC,Lee IT,Hsu CH,Hsu CK,Chi PL,Hsiao LD, Yang CM. Sphingosine-1-phosphate mediates ICAM-1-dependent monocyte adhesion through p38 MAPK and p42/p44 MAPK-dependent Akt activation . PLOS ONE .2015 ;(10):e0118473

30. 2015 Tsai CP,Wang KC,Hwang CS,Lee IT,Lee CT. Incidence, prevalence, and medical expenditures of classical amyotrophic lateral sclerosis in Taiwan, 1999-2008 . Journal of the Formosan Medical Association .2015 ;(114):612-619

31. 2015 Yang CM,Lin CC,Lee IT,Hsu CK,Tai YC,Hsieh HL, Chi PL, Hsiao LD. c-Src-dependent transactivation of EGFR mediates CORM-2-induced HO-1 expression in human tracheal smooth muscle cells . Journal of Cellular Physiology .2015 ;(230):2351-2361

32. 2014 Tsai CL,Chen WC,Lee IT,Chi PL,Cheng SE,Yang CM. c-Src-dependent transactivation of PDGFR contributes to TNF-alpha-induced MMP-9 expression and functional impairment in osteoblasts . Bone .2014 ;(60):186-197

33. 2014 Hsu CK,Lee IT,Lin CC,Hsiao LD,Yang CM. Nox2/ROS-dependent human antigen R translocation contributes to TNF-alpha-induced SOCS-3 expression in human tracheal smooth muscle cells . American Journal of Physiology-Lung Cellular and Molecular Physiology .2014 ;(306):L521-L533

34. 2014 Yang CM,Lee IT,Chi PL,Cheng SE,Hsiao LD,Hsu CK. TNF-alpha induces cytosolic phospholipase A2 expression via Jak2/PDGFR-dependent Elk-1/p300 activation in human lung epithelial cells . American Journal of Physiology-Lung Cellular and Molecular Physiology .2014 ;(306):L543-L551

35. 2014 Cheng SE,Lee IT,Lin CC,Hsiao LD,Yang CM. Thrombin induces ICAM-1 expression in human lung epithelial cells via c-Src/PDGFR/PI3K/Akt-dependent NF-kappaB/p300 activation . Clinical Science .2014 ;(127):171-183

36. 2014 Chi PL,Liu CJ,Lee IT,Chen YW,Hsiao LD,Yang CM. HO-1 induction by CO-RM2 attenuates TNF-alpha-induced cytosolic phospholipase A2 expression via inhibition of PKCalpha-dependent NADPH oxidase/ROS and NF-kappaB . Mediators of Inflammation .2014 ;(2014):279171

37. 2014 Lee IT,Lin CC,Hsu CK,Wu MY,Cho RL,Yang CM. Resveratrol inhibits Staphylococcus aureus-induced TLR2/MyD88/NF-kappaB-dependent VCAM-1 expression in human lung epithelial cells . Clinical Science .2014 ;(127):375-390

38. 2014 Lin CC,Lee IT,Chi PL,Hsieh HL,Cheng SE,Hsiao LD, Liu CJ, Yang CM. c-Src/Jak2/PDGFR/PKCdelta-dependent MMP-9 induction is required for thrombin-stimulated rat brain astrocytes migration . Molecular Neurobiology .2014 ;(49):658-672

39. 2013 Lee IT,Lin CC,Cheng SE,Hsiao LD,Hsiao YC,Yang CM. TNF-alpha induces cytosolic phospholipase A2 expression in human lung epithelial cells via JNK1/2- and p38 MAPK-dependent AP-1 activation . PLOS ONE .2013 ;(8):e72783

40. 2013 Lee IT,Lin CC,Lee CY,Hsieh PW,Yang CM. Protective effects of (-)-epigallocatechin-3-gallate against TNF-alpha-induced lung inflammation via ROS-dependent ICAM-1 inhibition . Journal of Nutritional Biochemistry .2013 ;(24):124-136

41. 2013 Lee CT,Chiu YW,Wang KC,Hwang CS,Lin KH,Lee IT, Tsai CP. Riluzole and prognostic factors in amyotrophic lateral sclerosis long-term and short-term survival: a population-based study of 1149 cases in Taiwan . Journal of Epidemiology .2013 ;(23):35-40

42. 2013 Lee IT,Lin CC,Wang CH,Cherng WJ,Wang JS,Yang CM. ATP stimulates PGE2/cyclin D1-dependent VSMCs proliferation via STAT3 activation: role of PKCs-dependent NADPH oxidase/ROS generation . Biochemical Pharmacology .2013 ;(85):954-964

43. 2013 Cheng SE,Lee IT,Lin CC,Wu WL,Hsiao LD,Yang CM. ATP mediates NADPH oxidase/ROS generation and COX-2/PGE2 expression in A549 cells: role of P2 receptor-dependent STAT3 activation . PLOS ONE .2013 ;(8):e54125

44. 2013 Yang CM,Lee IT,Lin CC,Wang CH,Cherng WJ,Hsiao LD. c-Src-dependent MAPKs/AP-1 activation is involved in TNF-alpha-induced matrix metalloproteinase-9 expression in rat heart-derived H9c2 cells . Biochemical Pharmacology .2013 ;(85):1115-1123

45. 2013 Tseng HC,Lee IT,Lin CC,Chi PL,Cheng SE,Shih RH, Hsiao LD, Yang CM. IL-1beta promotes corneal epithelial cell migration by increasing MMP-9 expression through NF-kappaB- and AP-1-dependent pathways . PLOS ONE .2013 ;(8):e57955

46. 2013 Lin CC,Lee IT,Wu WB,Liu CJ,Hsieh HL,Hsiao LD, Yang CC, Yang CM. Thrombin mediates migration of rat brain astrocytes via PLC, Ca2+, CaMKII, PKCalpha, and AP-1-dependent matrix metalloproteinase-9 expression . Molecular Neurobiology .2013 ;(48):616-630

47. 2013 Lee IT,Lin CC,Lin WN,Wu WL,Hsiao LD,Yang CM. Lung inflammation caused by adenosine-5'-triphosphate is mediated via Ca2+/PKCs-dependent COX-2/PGE2 induction . International Journal of Biochemistry & Cell Biology .2013 ;(45):1657-1668

48. 2013 Lee IT,Yang CM. Inflammatory signalings involved in airway and pulmonary diseases . Mediators of Inflammation .2013 ;(2013):791231

49. 2013 Yang CM,Lee IT,Hsu RC,Chi PL,Hsiao LD. NADPH oxidase/ROS-dependent PYK2 activation is involved in TNF-alpha-induced matrix metalloproteinase-9 expression in rat heart-derived H9c2 cells . Toxicology and Applied Pharmacology .2013 ;(272):431-442

50. 2012 Lee IT,Shih RH,Lin CC,Chen JT,Yang CM. Role of TLR4/NADPH oxidase/ROS-activated p38 MAPK in VCAM-1 expression induced by lipopolysaccharide in human renal mesangial cells . Cell Communication and Signaling .2012 ;(10):33

51. 2012 Yang CM,Lin CC,Lee IT,Lin YH,Yang CM,Chen WJ, Jou MJ, Hsiao LD. Japanese encephalitis virus induces matrix metalloproteinase-9 expression via a ROS/c-Src/PDGFR/PI3K/Akt/MAPKs-dependent AP-1 pathway in rat brain astrocytes . Journal of Neuroinflammation .2012 ;(9):12

52. 2012 Lee IT,Yang CM. Role of NADPH oxidase/ROS in pro-inflammatory mediators-induced airway and pulmonary diseases . Biochemical Pharmacology .2012 ;(84):581-590

53. 2012 Lin CC,Lee IT,Wu WL,Lin WN,Yang CM. Adenosine triphosphate regulates NADPH oxidase activity leading to hydrogen peroxide production and COX-2/PGE2 expression in A549 cells . American Journal of Physiology-Lung Cellular and Molecular Physiology .2012 ;(303):L401-L412

54. 2011 Tung WH,Hsieh HL,Lee IT,Yang CM. Enterovirus 71 modulates a COX-2/PGE2/cAMP-dependent viral replication in human neuroblastoma cells: role of the c-Src/EGFR/p42/p44 MAPK/CREB signaling pathway . Journal of Cellular Biochemistry .2011 ;(112):559-570

55. 2011 Cheng SE,Lin CC,Lee IT,Hsu CK,Kou YR,Yang CM. Cigarette smoke extract regulates cytosolic phospholipase A2 expression via NADPH oxidase/MAPKs/AP-1 and p300 in human tracheal smooth muscle cells . Journal of Cellular Biochemistry .2011 ;(112):589-599

56. 2011 Tung WH,Hsieh HL,Lee IT,Yang CM. Enterovirus 71 induces integrin beta1/EGFR-Rac1-dependent oxidative stress in SK-N-SH cells: role of HO-1/CO in viral replication . Journal of Cellular Physiology .2011 ;(226):3316-3329

57. 2011 Lee CW,Lin CC,Lee IT,Lee HC,Yang CM. Activation and induction of cytosolic phospholipase A2 by TNF-alpha mediated through Nox2, MAPKs, NF-kappaB, and p300 in human tracheal smooth muscle cells . Journal of Cellular Physiology .2011 ;(226):2103-2114

58. 2011 Chi PL,Luo SF,Hsieh HL,Lee IT,Hsiao LD,Chen YL, Yang CM. Cytosolic phospholipase A2 induction and prostaglandin E2 release by interleukin-1beta via the myeloid differentiation factor 88-dependent pathway and cooperation of p300, Akt, and NF-kappaB activity in human rheumatoid arthritis synovial fibroblasts . Arthritis & Rheumatism .2011 ;(63):2905-2917

59. 2010 Lin CC,Lee IT,Yang YL,Lee CW,Kou YR,Yang CM. Induction of COX-2/PGE2/IL-6 is crucial for cigarette smoke extract-induced airway inflammation: Role of TLR4-dependent NADPH oxidase activation . Free Radical Biology & Medicine .2010 ;(48):240-254

60. 2010 Lee CW,Lee IT,Lin CC,Lee HC,Lin WN,Yang CM. Activation and induction of cytosolic phospholipase A2 by IL‐1beta in human tracheal smooth muscle cells: Role of MAPKs/p300 and NF‐kappaB . Journal of Cellular Biochemistry .2010 ;(109):1045-1056

61. 2010 Lee IT,Lee CW,Tung WH,Wang SW,Lin CC,Shu JC, Yang CM. Cooperation of TLR2 with MyD88, PI3K, and Rac1 in lipoteichoic acid-induced cPLA2/COX-2-dependent airway inflammatory responses . American Journal of Pathology .2010 ;(176):1671-1684

62. 2010 Cheng SE,Lee IT,Lin CC,Kou YR,Yang CM. Cigarette smoke particle-phase extract induces HO-1 expression in human tracheal smooth muscle cells: role of the c-Src/NADPH oxidase/MAPK/Nrf2 signaling pathway . Free Radical Biology & Medicine .2010 ;(48):1410-1422

63. 2010 Tung WH,Lee IT,Hsieh HL,Yang CM. EV71 induces COX-2 expression via c-Src/PDGFR/PI3K/Akt/p42/p44 MAPK/AP-1 and NF-kappaB in rat brain astrocytes . Journal of Cellular Physiology .2010 ;(224):376-386

64. 2010 Lee IT,Lin CC,Wu YC,Yang CM. TNF-alpha induces matrix metalloproteinase-9 expression in A549 cells: role of TNFR1/TRAF2/PKCalpha-dependent signaling pathways . Journal of Cellular Physiology .2010 ;(224):454-464

65. 2010 Shih RH,Lee IT,Hsieh HL,Kou YR,Yang CM. Cigarette smoke extract induces HO-1 expression in mouse cerebral vascular endothelial cells: involvement of c-Src/NADPH oxidase/PDGFR/JAK2/STAT3 pathway . Journal of Cellular Physiology .2010 ;(225):741-750

66. 2010 Tung WH,Tsai HW,Lee IT,Hsieh HL,Chen WJ,Chen YL, Yang CM. Japanese encephalitis virus induces matrix metalloproteinase-9 in rat brain astrocytes via NF-kappaB signalling dependent on MAPKs and reactive oxygen species . British Journal of Pharmacology .2010 ;(161):1566-1583

67. 2009 Cheng SE,Luo SF,Jou MJ,Lin CC,Kou YR,Lee IT, Hsieh HL, Yang CM. Cigarette smoke extract induces cytosolic phospholipase A2 expression via NADPH oxidase, MAPKs, AP-1, and NF-kappaB in human tracheal smooth muscle cells . Free Radical Biology & Medicine .2009 ;(46):948-960

68. 2009 Luo SF,Chang CC,Lee IT,Lee CW,Lin WN,Lin CC, Yang CM. Activation of ROS/NF-kappaB and Ca2+/CaM kinase II are necessary for VCAM-1 induction in IL-1beta-treated human tracheal smooth muscle cells . Toxicology and Applied Pharmacology .2009 ;(237):8-21

69. 2009 Lee IT,Luo SF,Lee CW,Wang SW,Lin CC,Chang CC, Chen YL, Chau LY, Yang CM. Overexpression of HO-1 protects against TNF-alpha-mediated airway inflammation by down-regulation of TNFR1-dependent oxidative stress . American Journal of Pathology .2009 ;(175):519-532

70. 2009 Lin CC,Kuo CT,Cheng CY,Wu CY,Lee CW,Hsieh HL, Lee IT, Yang CM. IL-1beta promotes A549 cell migration via MAPKs/AP-1- and NF-kappaB-dependent matrix metalloproteinase-9 expression . Cellular Signalling .2009 ;(21):1652-1662

71. 2009 Yang CM,Lee IT,Lin CC,Yang YL,Luo SF,Kou YR, Hsiao LD. Cigarette smoke extract induces COX-2 expression via a PKCalpha/c-Src/EGFR, PDGFR/PI3K/Akt/NF-kappaB pathway and p300 in tracheal smooth muscle cells . American Journal of Physiology-Lung Cellular and Molecular Physiology .2009 ;(297):L892-L902

72. 2008 Lee CW,Lin CC,Luo SF,Lee HC,Lee IT,Aird WC, Hwang TL, Yang CM. Tumor necrosis factor-alpha enhances neutrophil adhesiveness: induction of vascular cell adhesion molecule-1 via activation of Akt and CaM kinase II and modifications of histone acetyltransferase and histone deacetylase 4 in human tracheal smooth muscle cells . Molecular Pharmacology .2008 ;(73):1454-1464

73. 2008 Luo SF,Lin CC,Chen HC,Lin WN,Lee IT,Lee CW, Hsiao LD, Yang CM. Involvement of MAPKs, NF-kappaB and p300 co-activator in IL-1beta-induced cytosolic phospholipase A2 expression in canine tracheal smooth muscle cells . Toxicology and Applied Pharmacology .2008 ;(232):396-407

74. 2008 Lee IT,Wang SW,Lee CW,Chang CC,Lin CC,Luo SF, Yang CM. Lipoteichoic acid induces HO-1 expression via the TLR2/MyD88/c-Src/NADPH oxidase pathway and Nrf2 in human tracheal smooth muscle cells . Journal of Immunology .2008 ;(181):5098-5110

75. 2007 Lin SJ,Lee IT,Chen YH,Lin FY,Sheu LM,Ku HH, Shiao MS, Chen JW, Chen YL. Salvianolic acid B attenuates MMP-2 and MMP-9 expression in vivo in apolipoprotein-E-deficient mouse aorta and in vitro in LPS-treated human aortic smooth muscle cells . Journal of Cellular Biochemistry .2007 ;(100):372-384


1. 2019 Lee IT. Carbon monoxide releasing molecule-2 attenuates Pseudomonas aeruginosa-induced ROS-dependent ICAM-1 expression in human pulmonary alveolar epithelial cells . 臺北醫學大學107學年度師生聯合學術研究發表會 .2019

2. 2019 Lee IT. Carbon monoxide releasing molecule-2 protects against particulate matter-induced lung inflammation by inhibiting TLR2 and 4/ROS/NLRP3 inflammasome activation . 台灣毒物學學會第一屆墾丁冬令營 .2019

3. 2019 Lee IT. Carbon monoxide releasing molecule-2 protects against particulate matter-induced lung inflammation by inhibiting TLR2 and 4/ROS/NLRP3 inflammasome activation . 第34屆生物醫學聯合學術年會 .2019

4. 2019 Lee IT. Extracts of Artocarpus communis promotes mitochondria-related apoptosis through pro-oxidative activity in glioblastoma cells . 2019 Southeast Asia Symposium of Traditional Medicine .2019

5. 2018 Zeng CL,Lee IT. Carbon monoxide releasing molecule-2 inhibits Pseudomonas aeruginosa-induced lung inflammatory responses . 第33屆生物醫學聯合學術年會 .2018

6. 2018 Li SY,Lee IT. Artocarpin induces mitochondria-associated cell death through reactive oxygen species signaling in human glioblastoma cells . 第33屆生物醫學聯合學術年會 .2018

7. 2018 Lee IT. CO-releasing molecules-2 attenuates angiotensin II-induced human aortic smooth muscle cell migration through inhibition of ROS/IL-6 generation and matrix metalloproteinases-9 expression . 第33屆生物醫學聯合學術年會 .2018

8. 2018 How JM,Lee IT. The protective mechanisms of resveratrol on particulate matter-induced COX-2 expression in human fibroblast-like synoviocytes . 第33屆生物醫學聯合學術年會 .2018

9. 2018 Zeng CL,Lee IT. Carbon monoxide releasing molecule-2 inhibits Pseudomonas aeruginosa-induced lung inflammatory responses . 2018年中國醫藥大學暨亞洲大學生物科技研討會 .2018

10. 2018 Lee IT. CO attenuates angiotensin II-induced human aortic smooth muscle cell migration through inhibition of ROS/IL-6 generation and matrix metalloproteinases-9 expression . 2018年中國醫藥大學暨亞洲大學生物科技研討會 .2018

11. 2018 Zeng CL,Lee IT. 一氧化碳釋放分子-2抑制綠膿桿菌所誘發的肺部發炎反應 . 2018年生物醫學國際研討會 .2018

12. 2018 Lee IT. 一氧化碳透過抑制ROS/IL-6產生和基質金屬蛋白酶-9表現來減少血管收縮素II誘導的人主動脈平滑肌細胞移行作用 . 2018年生物醫學國際研討會 .2018

13. 2018 Lee IT. Resveratrol protects against Staphylococcus aureus-induced lung inflammation through reduction of VCAM-1 expression . 第33屆天然藥物國際研討會 .2018

14. 2018 Chuang CC,Lee IT. Infection with Staphylococcus aureus elicits COX-2/PGE2/IL-6/MMP-9-dependent aorta inflammation via the inhibition of intracellular ROS production . 2018 NHRI/IBMS Joint International Conference on Inflammation & Disease .2018

15. 2018 Lee IT. Carbon monoxide releasing molecule-2 attenuates Pseudomonas aeruginosa-induced ROS-dependent ICAM-1 expression in human pulmonary alveolar epithelial cells . 2018 NHRI/IBMS Joint International Conference on Inflammation & Disease .2018

16. 2017 Li SY,Lee IT. Artocarpin induces mitochondria-associated cell death through reactive oxygen species signaling in human glioblastoma cells . 第32屆生物醫學聯合學術年會 .2017

17. 2017 Lee IT. Exogenous carbon monoxide attenuates angiotensin II-induced migration of human aortic smooth muscle cells through inactivation of AT1R/NADPH oxidase/ROS/IL-6/MMP-9 . 第32屆生物醫學聯合學術年會 .2017

18. 2017 How JM,Lee IT. 研究白藜蘆醇對抗細懸浮微粒PM2.5誘發人類滑液膜中纖維母細胞發炎之保護機轉 . 第32屆生物醫學聯合學術年會 .2017

19. 2017 Lee IT. CORM2 attenuates angiotensin II-induced human aortic smooth muscle cell migration through inhibition of ROS/IL-6 generation and matrix metalloproteinases-9 expression . 第十屆生物科技研討會 .2017

20. 2017 Li SY,Lee IT. Artocarpin induces mitochondria-associated cell death through reactive oxygen species signaling in human glioblastoma cells . 第十屆生物科技研討會 .2017

21. 2017 How JM,Lee IT. Resveratrol inhibits urban particulate matter-induced COX-2/PGE2 release in human fibroblast-like synoviocytes via the inhibition of activation of NADPH oxidase/ROS/NF-kappaB . 第十屆生物科技研討會 .2017

22. 2017 Zeng CL,Lee IT. Resveratrol inhibits Staphylococcus aureus-induced TLR2/MyD88/NF-kappaB-dependent VCAM-1 expression in human lung epithelial cells . 第32屆天然藥物研討會 .2017

23. 2017 Li SY,Lee IT. Artocarpin induces mitochondria-associated cell death through reactive oxygen species signaling in human glioblastoma cells . 第32屆天然藥物研討會 .2017

24. 2017 How JM,Lee IT. The protective mechanisms of resveratrol on particulate matter-induced COX-2 expression in human fibroblast-like synoviocytes . 第32屆天然藥物研討會 .2017

25. 2016 Lee IT. 探討麵包樹活性成分artocarpin誘發神經膠質瘤細胞凋亡之抗癌機轉 . 第三十一屆生物醫學聯合學術年會 .2016

26. 2016 Lee IT. 白藜蘆醇對金黃色葡萄球菌引起肺部發炎的保護作用 . 第三十一屆生物醫學聯合學術年會 .2016

27. 2016 How JM,Lee IT. 探討白藜蘆醇減緩空氣污染粒子引發人類風濕性關節炎之滑液膜纖維母細胞表現COX-2之保護機轉 . 第三十一屆生物醫學聯合學術年會 .2016

28. 2016 Li SY,Lee IT. The anticancer mechanisms of Artocarpin-induced apoptosis of glioblastoma cells . 第九屆中國醫藥大學暨亞洲大學生物科技研討會 .2016

29. 2016 Chang CM,Lee IT. ATP stimulates PGE2/cyclin D1-dependent VSMCs proliferation via STAT3 activation . 第九屆中國醫藥大學暨亞洲大學生物科技研討會 .2016

30. 2016 Zeng CL,Lee IT. Resveratrol protects against Staphylococcus aureus-induced lung inflammation through reduction of VCAM-1 expression . 第九屆中國醫藥大學暨亞洲大學生物科技研討會 .2016

31. 2016 How JM,Lee IT. The protective mechanisms of resveratrol on PM2.5-induced COX-2 expression in human rheumatoid arthritis synovial fibroblasts . 第九屆中國醫藥大學暨亞洲大學生物科技研討會 .2016

32. 2016 Wu CM,Lee IT. Thrombin enhances NF-kappaB/p300-dependent ICAM-1 expression in human pulmonary alveolar epithelial cells . 第九屆中國醫藥大學暨亞洲大學生物科技研討會 .2016

33. 2016 Wu CM,Lee IT. Thrombin enhances NF-kappaB/p300-dependent ICAM-1 expression in human pulmonary alveolar epithelial cells . 2016年生物醫學國際研討會 .2016

34. 2016 How JM,Lee IT. The protective mechanisms of resveratrol on PM2.5-induced COX-2 expression in human rheumatoid arthritis synovial fibroblasts . 2016年生物醫學國際研討會 .2016

35. 2016 Li SY,Lee IT. Artocarpin induces mitochondria-associated cell death through reactive oxygen species signaling in human glioblastoma cells . 2016年生物醫學國際研討會 .2016

36. 2016 Zeng CL,Lee IT. LPS induces ICAM-1 expression in human pulmonary alveolar epithelial cells via a TLR4/MyD88/TRAF6/NADPH oxidase-dependent pathway . 2016年生物醫學國際研討會 .2016

37. 2016 Chang CM,Lee IT. ATP stimulates PGE2/cyclin D1-dependent VSMCs proliferation via STAT3 activation . 2016年生物醫學國際研討會 .2016

38. 2016 Wu CM,Lee IT. 白藜蘆醇對金黃色葡萄球菌引起肺部發炎的保護作用 . 2016發炎新知國際研討會 .2016

39. 2016 Lee IT. 探討白藜蘆醇減緩空氣污染粒子引發人類風濕性關節炎之滑液膜纖維母細胞表現COX-2之保護機轉 . 2016發炎新知國際研討會 .2016

40. 2015 How JM,Lee IT. 探討白藜蘆醇減緩空氣污染粒子引發類風濕性關節炎之保護機轉 . 中國醫藥大學104年度暑期科學研習營暨精進學習群成果發表會 .2015

41. 2015 How JM,Lee IT. 探討白藜蘆醇減緩空氣污染粒子引發類風濕性關節炎之保護機轉 . 財團法人健康科學文教基金會第十屆醫學系學生暑期研究計畫研究成果發表會 .2015

42. 2014 Lee IT,Yang CM. Resveratrol inhibits Staphylococcus aureus-induced TLR2/MyD88/NF-kappaB-dependent VCAM-1 expression in human lung epithelial cells . The 29th Joint Annual Conference of Biomedical Science .2014

43. 2013 Lee IT,Yang CM. ATP stimulates PGE2/cyclin D1-dependent VSMCs proliferation via STAT3 activation: role of PKCs-dependent NADPH oxidase/ROS generation . The 28th Joint Annual Conference of Biomedical Science .2013

44. 2013 Lee IT,Yang CM. ATP stimulates PGE2/cyclin D1-dependent VSMCs proliferation via STAT3 activation: role of PKCs-dependent NADPH oxidase/ROS generation . Biennial Meeting of Society for Free Radical Research-Asia .2013

45. 2012 Lee IT,Yang CM. Protective effects of (-)-epigallocatechin-3-gallate against TNF-alpha-induced lung inflammation via ROS-dependent ICAM-1 inhibition . The 27th Joint Annual Conference of Biomedical Science .2012

46. 2010 Lee IT,Yang CM. Induction of COX-2/PGE2/IL-6 is crucial for cigarette smoke extract-induced airway inflammation: Role of TLR4-dependent NADPH oxidase activation . The 25th Joint Annual Conference of Biomedical Science .2010

47. 2009 Lee IT,Yang CM. Overexpression of HO-1 protects against TNF-alpha-mediated airway inflammation by down-regulation of TNFR1-dependent oxidative stress . The 24th Joint Annual Conference of Biomedical Science .2009

48. 2009 Lee IT,Yang CM. Overexpression of HO-1 protects against TNF-alpha-mediated airway inflammation by down-regulation of TNFR1-dependent oxidative stress . The American Society for Cell Biology 2009 Annual Meeting .2009

49. 2008 Lee IT,Yang CM. Lipoteichoic acid induces HO-1 expression via the TLR2/MyD88/c-Src/NADPH oxidase pathway and Nrf2 in human tracheal smooth muscle cells . The 23th Joint Annual Conference of Biomedical Science .2008

50. 2008 Lee IT,Yang CM. Lipoteichoic acid induces HO-1 expression via the TLR2/MyD88/c-Src/NADPH oxidase pathway and Nrf2 in human tracheal smooth muscle cells . Experimental Biology 2008 .2008

51. 2007 Lee IT,Yang CM. Lipoteichoic acid-induced expression of cytosolic phospholipase A2 in human tracheal smooth muscle cells . The 22th Joint Annual Conference of Biomedical Science .2007

52. 2005 Lee IT,Chen YL. Salvianolic acid B attenuates MMP-2 and MMP-9 expression in vivo in apolipoprotein-E-deficient mouse aorta and in vitro in LPS-treated human aortic smooth muscle cells . The 20th Joint Annual Conference of Biomedical Science .2005


1. 2016 朱培銘,吳政訓,柯妙華,張綺芬,李宜達,楊美芳, 蔡孟宏, 魏一華. 實用解剖實習指引 . 力大圖書有限公司 .2016

研究計畫

計畫名稱
108 新聘教師研究補助
補助單位
臺北醫學大學