張育嘉(Chang, Yu-Jia) 教授

Email
r5424012@tmu.edu.tw
現   職
臨床醫學研究所 教授

學經歷

學 歷

畢業學校與學位[修業時間]
國立成功大學基礎醫學研究所 博士
1998/09~2003/10
國立臺灣大學醫事技術學系 碩士
1996/09~1998/08
國立臺灣大學醫事技術學系 學士
1989/09~1994/08

本校學術經歷

任職單位與職稱[起迄時間]
臨床醫學研究所教授
2013/02/01~
臨床醫學研究所副教授
2010/02/01~2013/01/31
外科學科助理教授
2007/02/01~2010/01/31

本校行政經歷

服務單位與職稱[起迄時間]
國際醫學研究碩士學位學程教授
2018/02/01 ~
國際醫學研究博士學位學程教授
2018/02/01 ~
細胞治療與再生醫學國際博士學位教授
2018/02/01 ~
國際醫學研究博士學位學程教授
2016/11/01 ~ 2017/10/31
國際醫學研究碩士學位學程教授
2016/11/01 ~ 2017/10/31
實驗動物中心主任
2011/10/01 ~ 2012/10/31

其它經歷

任職單位與職稱[起迄時間]
羅徹斯特大學pathology博士後研究
2004/11~2006/08
成功大學生化所博士後研究
2003/11~2004/10

專長與研究領域

學門領域
Molecular Biology(分生)
Protein Chemistry(蛋白質化學)
Emzymology(酵素學)
Hematology(血液學)
Cancer Biology (癌症生物學)
Biochemistry (生化學)
學術專長
Cloning
Xenograft animal model
portein expression and purification

論文著作

清冊下載


1. 2020 Kao WY, ,Chang IW, ,Chen CL, ,Su CW, ,Fang SU, ,Tang JH, Chang CC, Chang YJ, Wang W. Fibroscan-Based Score to Predict Significant Liver Fibrosis in Morbidly Obese Patients with Nonalcoholic Fatty Liver Disease . Obes Surg .2020 ;(0):00-00

2. 2019 Huang CY, ,Wei PL, ,Wang JW, ,Makondi PT, ,Huang MT, ,Chen HA, Chang YJ. Glucose-Regulated Protein 94 Modulates the Response of Osteosarcoma to Chemotherapy. . Dis Markers. .2019 ;(0):4569718-4569718

3. 2019 Chang TC, ,Wei PL, ,Makondi PT, ,Chen WT, ,Huang CY, ,Chang YJ. Bromelain inhibits the ability of colorectal cancer cells to proliferate via activation of ROS production and autophagy. . PLoS One .2019 ;(14):e0210274-e0210274

4. 2019 Wei PL, ,Huang CY, ,Chang YJ. Propyl gallate inhibits hepatocellular carcinoma cell growth through the induction of ROS and the activation of autophagy. . PLoS One. .2019 ;(14):e0210513-e0210513

5. 2019 Makondi PT, ,Wei PL, ,Huang CY, ,Chang YJ.. Development of novel predictive miRNA/target gene pathways for colorectal cancer distance metastasis to the liver using a bioinformatic approach. . PLoS One .2019 ;(14):e0211968-e0211968

6. 2019 Hsu HM, ,Chu CM, ,Chang YJ, ,Yu JC, ,Chen CT, ,Jian CE, Lee CY, Chiang YT, Chang CW, Chang YT.. Six novel immunoglobulin genes as biomarkers for better prognosis in triple-negative breast cancer by gene co-expression network analysis. . Sci Rep. .2019 ;(9):4484-4495

7. 2019 Yu CC, ,Chen LC, ,Chiou CY, ,Chang YJ, ,Lin VC, ,Huang CY, Lin IL, Chang TY, Lu TL, Lee CH, Huang SP, Bao BY.. Genetic variants in the circadian rhythm pathway as indicators of prostate cancer progression. . Cancer Cell Int. .2019 ;(19):87

8. 2019 Hung CS, ,Huang CY, ,Hsu YW, ,Makondi PT, ,Chang WC, ,Chang YJ, Wang JY, Wei PL. . HSPB1 rs2070804 polymorphism is associated with the depth of primary tumor. . J Cell Biochem .2019

9. 2019 Li CL, ,Lin YK, ,Chen HA, ,Huang CY, ,Huang MT, ,Chang YJ. Smoking as an Independent Risk Factor for Hepatocellular Carcinoma Due to the α7-Nachr Modulating the JAK2/STAT3 Signaling Axis. . J Clin Med. .2019 ;(8):E1391-E1391

10. 2018 Makondi PT,Lee CH,Huang CY,Chu CM,Chang YJ,Wei PL. Prediction of the novel target genes and pathways involved in bevacizumab-resistant colorectal cancer . PLOS ONE .2018 ;(13):e0189582

11. 2018 WAN-LI CHENG,CHIEN-YU HUANG,CHENG-JENG TAI,YU-JIA CHANG,CHIN-SHENG HUNG. Maspin Enhances the Anti-Cancer Activity of Curcumin in Hormone-Refractory Prostate Cancer Cells . Anticancer Res. 2018 .2018 ;(2):863-870

12. 2018 Chien-Yu Huang,Chia-Hwa Lee,Chao-Chiang Tu, Chih-Hsiung Wu,MingTe Huang,Po-Li Wei and Yu-Jia Chang. Glucose-regulated protein 94 mediates progression and metastasis of esophageal squamous cell carcinoma via mitochondrial function and the NFkb/COX-2/VEGF axis . Oncotarget. .2018 ;(10):9425-9441

13. 2018 Shih CM, ,Huang CY, ,Wang KH, ,Huang CY, ,Wei PL,,Chang YJ, Hsieh CK, Liu KT, Lee AW.. Oxidized Low-Density Lipoprotein-Deteriorated Psoriasis Is Associated with the Upregulation of Lox-1 Receptor and Il-23 Expression In Vivo and In Vitro. . Int J Mol Sci. .2018 ;(9):E2610

14. 2018 Shih CM, ,Huang CY, ,Huang CY, ,Wang KH, ,Wei PL, ,Chang YJ, Fong TH, Pan JL, Lee AW.. A dipeptidyl peptidase-4 inhibitor promotes wound healing in normoglycemic mice by modulating keratinocyte activity. . Exp Dermatol. .2018

15. 2018 Kan PC, ,Chang YJ, ,Chien CS, ,Su CY, ,Fang HW.. Coupling Dichloroacetate Treatment with Curcumin Significantly Enhances Anticancer Potential. . Anticancer Res. .2018

16. 2018 Hsu KW, ,Huang CY, ,Tam KW, ,Lin CY, ,Huang LC, ,Lin CL, Hsieh WS, Chi WM, Chang YJ, Wei PL, Chen ST, Lee CH.. The Application of Non-Invasive Apoptosis Detection Sensor (NIADS) on Histone Deacetylation Inhibitor (HDACi)-Induced Breast Cancer Cell Death. . Int J Mol Sci. .2018 ;(2):E452

17. 2018 Liang HH, ,Huang CY, ,Chou CW, ,Makondi PT, ,Huang MT, ,Wei PL, Chang YJ.. Heat shock protein 27 influences the anti-cancer effect of curcumin in colon cancer cells through ROS production and autophagy activation. . Life Sci. .2018

18. 2018 Huang EY, Chang YJ, Huang SP, ,Lin VC, ,Yu CC, ,Huang CY, ,Yin HL, ,Chang TY, Lu TL, Bao BY.. A common regulatory variant in SLC35B4 influences the recurrence and survival of prostate cancer. . J Cell Mol Med. 2018 Jul;22(7):-. doi: . .2018 ;(7):3661-3670

19. 2018 Chien-Yu Huang, Po-Li Wei ,Wei-Yu Chen,Wei-Chiao Chang ,Yu-Jia Chang. Silencing Heat Shock Protein 27 Inhibits the Progression and Metastasis of Colorectal Cancer (CRC) by Maintaining the Stability of Stromal Interaction Molecule 1 (STIM1) Proteins . Cells .2018

20. 2017 Hung Chin Sheng ,Huang Chien Yu ,Lee Chia Hwa ,Chen Wei Yu ,Huang Ming Te ,Wei PL, Chang YJ. IGFBP2 plays an important role in heat shock protein 27-mediated cancer progression and metastasis . Oncotarget .2017 ;(8):54978-54992

21. 2017 Makondi Precious Takondwa ,Chu Chi Ming ,Wei Po Li ,Chang Yu Jia . Prediction of novel target genes and pathways involved in irinotecan-resistant colorectal cancer . PLOS ONE .2017 ;(7):e0180616

22. 2017 Lin RK, ,Hung WY, ,Huang YF, ,Chang YJ, ,Lin CH, ,Chen WY, Chiu SF, Chang SC, Tsai SF.. Hypermethylation of BEND5 contributes to cell proliferation and is a prognostic marker of colorectal cancer. . Oncotarget .2017 ;(8):113431-113443

23. 2016 Tu CC,Huang CY,Cheng WL,Hung CS,Uyanga B,Wei PL, Chang YJ.. The α7-nicotinic acetylcholine receptor mediates the sensitivity of gastric cancer cells to taxanes. . Tumor Biology .2016 ;(37):4421-4428

24. 2016 Huang CY,Batzorig U,Cheng WL,Huang MT,Chen WY,Wei PL, Chang YJ.. Glucose-regulated protein 94 mediates cancer progression via AKT and eNOS in hepatocellular carcinoma. . Tumor Biology .2016 ;(37):4295-4304

25. 2016 Huang CY, Chang YJ,Luo SD,Uyanga B,Lin FY,Tai CJ,Huang MT.. Maspin mediates the gemcitabine sensitivity of hormone-independent prostate cancer. . Tumor Biology .2016 ;(37):4075-4082

26. 2016 Tu CC,Huang CY,Cheng WL,Hung CS,Chang YJ,Wei PL. Silencing A7-nAChR levels increases the sensitivity of gastric cancer cells to ixabepilone treatment. . Tumour Biol. .2016 ;(37):9493-9501

27. 2016 Chang YJ,Cheng YW,Lin RK,Huang CC,Chen WT,Ke TW, Wei PL. Thrombomodulin Influences the Survival of Patients with Non-Metastatic Colorectal Cancer through Epithelial-To-Mesenchymal Transition (EMT). . PLoS One. .2016 ;(11):e01605

28. 2016 Huang CY,Shih CM,Tsao NW,Lin YW,Shih CC,Chiang KH, Shyue SK, Chang YJ, Hsieh CK, Lin FY.. The GroEL protein of Porphyromonas gingivalis regulates atherogenic phenomena in endothelial cells mediated by upregulating toll-like receptor 4 expression. . Am J Transl Res. .2016 ;(8):384-404

29. 2016 Chien CW,Hou PC,Wu HC,Chang YL,Lin SC,Lin SC, Lin BW, Lee JC, Chang YJ, Sun HS, Tsai SJ.. Targeting TYRO3 inhibits epithelial-mesenchymal transition and increases drug sensitivity in colon cancer. . Oncogene .2016 ;(35):5872-5881

30. 2016 Tai CJ,Huang MT,Wu CH,Wang CK,Tai CJ,Chang CC, Hsieh CI, Chang YJ, Wu CJ, Kuo LJ, Wei PL, Chen RJ, Chiou HY.. Combination of Two Targeted Medications (Bevacizumab Plus Cetuximab) Improve the Therapeutic Response of Pancreatic Carcinoma. . Medicine (Baltimore). .2016 ;(95):e3259

31. 2016 Tai CJ,Wang H,Wang CK,Tai CJ,Huang MT,Wu CH, Chen RJ, Kuo LJ, Wei PL, Chang YJ, Chang CC, Chiou HY, Wu CJ.. Bevacizumab and cetuximab with conventional chemotherapy reduced pancreatic tumor weight in mouse pancreatic cancer xenografts. . Clin Exp Med. .2016 ;(0):0-0

32. 2016 Hsieh CL,Ma HP,Su CM,Chang YJ,Hung WY,Ho YS, Huang WJ, Lin RK. Alterations in histone deacetylase 8 lead to cell migration and poor prognosis in breast cancer. . Life Sci. .2016 ;(15):7-14

33. 2016 Luo JD,Chang YJ,Chang CM,You JF,Wei PL,Chiou CC. GeneGazer: A Toolkit Integrating Two Pipelines for Personalized Profiling and Biosignature Identification. . Cancer Genomics Proteomics. .2016 ;(13):141-150

34. 2016 Wei PL,Huang CY,Tai CJ,Batzorig U,Cheng WL,Hunag MT, Chang YJ. Glucose-regulated protein 94 mediates metastasis by CCT8 and the JNK pathway in hepatocellular carcinoma. . Tumour Biol. .2016 ;(37):8219-8227

35. 2016 Tai CJ,Huang MT,Wu CH,Tai CJ,Shi YC,Chang CC, Chang YJ, Kuo LJ, Wei PL, Chen RJ, Chiou HY. Contrast-Enhanced Ultrasound and Computed Tomography Assessment of Hepatocellular Carcinoma after Transcatheter Arterial Chemo-Embolization: A Systematic Review. . J Gastrointestin Liver Dis. .2016 ;(25):499-507

36. 2015 Wang RC, Huang CY, P,Chen WY,Ho CT,Liu TZ,Chang YJ. Proteomic Characterization of Annexin l (ANX1) and Heat Shock Protein 27 (HSP27) as Biomarkers for Invasive Hepatocellular Carcinoma Cells. . PLoS One .2015 ;(10):013923

37. 2015 Ho CT,Chang YJ,Yang LX,Wei PL,Liu TZ,Liu JJ.. A Novel Microtubule-Disrupting Agent Induces Endoplasmic Reticular Stress-Mediated Cell Death in Human Hepatocellular Carcinoma Cells. . PLOS ONE .2015 ;(10):e01363

38. 2015 Wang CK,Lin YF,Tai CJ,Wang CW,Chang YJ,Choong CY, Lin CS, Tai CJ, Chang CC.. Integrated Treatment of Aqueous Extract of Solanum nigrum-Potentiated Cisplatin- and Doxorubicin-Induced Cytotoxicity in Human Hepatocellular Carcinoma Cells. . Evid Based Complement Alternat Med. .2015

39. 2015 Chen WY,Huang CY,Cheng WL,Hung CS,Huang MT,Tai CJ, Liu YN, Chen CL, Chang YJ.. Alpha 7-nicotinic acetylcholine receptor mediates the sensitivity of gastric cancer cells to 5-fluorouracil. . Tumor Biology .2015

40. 2015 Wang CW,Chen CL,Wang CK,Chang YJ,Jian JY,Lin CS, Tai CJ, Tai CJ.. Cisplatin-, Doxorubicin-, and Docetaxel-Induced Cell Death Promoted by the Aqueous Extract of Solanum nigrum in Human Ovarian Carcinoma Cells. . Integr Cancer Ther. .2015 ;(14):546-555

41. 2015 Wang CW,Wang CK,Chang YJ,Choong CY,Lin CS,Tai CJ, Tai CJ.. Preclinical evaluation on the tumor suppression efficiency and combination drug effects of fermented wheat germ extract in human ovarian carcinoma cells. . Evid Based Complement Alternat Med. .2015

42. 2015 Kuo LJ,Huang CY,Cheng WL,Hung CS,Wu CT,Lin FY, Chang YJ, Huang MT.. Glucose-regulated protein 78 mediates the anticancer efficacy of shikonin in hormone-refractory prostate cancer cells. . Tumor Biology .2015 ;(36):5063-5070

43. 2015 Chang YJ,Huang CY,Hung CS,Liu HH,Wei PL. Glucose-regulated protein 78 mediates the therapeutic efficacy of 17-DMAG in colon cancer cells. . Tumor Biology .2015 ;(36):4367-4376

44. 2015 Chang YJ,Chen WY,Huang CY,Liu HH,Wei PL. Glucose-regulated protein 78 (GRP78) regulates colon cancer metastasis through EMT biomarkers and the NRF-2/HO-1 pathway. . Tumor Biology .2015 ;(36):1859-1869

45. 2015 Kao WY,Chao Y,Chang CC,Li CP,Su CW,Huo TI, Huang YH, Chang YJ, Lin HC, Wu JC.. Prognosis of Early-Stage Hepatocellular Carcinoma: The Clinical Implications of Substages of Barcelona Clinic Liver Cancer System Based on a Cohort of 1265 Patients. . Medicine .2015 ;(94):1929-1935

46. 2015 Chang YJ,Huang CY,Hung CS,Chen WY,Wei PL.. GRP78 mediates the therapeutic efficacy of curcumin on colon cancer. . Tumor Biology .2015 ;(36):633-641

47. 2015 Lin FY,Huang CY,Lu HY,Shih CM,Tsao NW,Shyue SK, Lin CY, Chang YJ, Tsai CS, Lin YW, Lin SJ. The GroEL protein of Porphyromonas gingivalis accelerates tumor growth by enhancing endothelial progenitor cell function and neovascularization. . Mol Oral Microbiol. .2015 ;(30):198-216

48. 2014 Chang YJ,Li LT,Chen HA,Hung CS,Wei PL. Silencing survivin activates autophagy as an alternative survival pathway in HCC cells. . Tumor Biology .2014 ;(35):9957-9966

49. 2014 Lin CS,Chen PC,Wang CK,Wang CW,Chang YJ,Tai CJ, Tai CJ.. Antitumor Effects and Biological Mechanism of Action of the Aqueous Extract of the Camptotheca acuminata Fruit in Human Endometrial Carcinoma Cells. . Evid Based Complement Alternat Med. .2014 ;(0):564810-564815

50. 2014 Wang SC,Lee TH,Hsu CH,Chang YJ,Chang MS,Wang YC, Ho YS, Wen WC, Lin RK.. Antroquinonol D, isolated from Antrodia camphorata, with DNA demethylation and anticancer potential. . J Agric Food Chem. .2014 ;(62):5625-5635

51. 2014 Hung CS,Su HY,Liang HH,Lai CW,Chang YC,Ho YS, Wu CH, Ho JD, Wei PL, Chang YJ.. High-level expression of CXCR4 in breast cancer is associated with early distant and bone metastases . Tumor Biology .2014 ;(35):1581-1588

52. 2014 Tai CJ, ,Wang JW, ,Su HY, ,Tai CJ, ,Wang CK, ,Wu CT, Lien YC, Chang YJ. Glucose-regulated protein 94 modulates the therapeutic efficacy to taxane in cervical cancer cells. . Tumour Biol .2014 ;(35):403-410

53. 2014 Wu CT, Chang YJ,,Chen MF,Liu JJ,Wei PL,Wang W,Liu HH. Thrombomodulin mediates the migratory ability of hormone-independent prostate cancer cells through the regulation of epithelial-to-mesenchymal transition biomarkers. . Tumor Biology .2014 ;(35):6047-6054

54. 2014 Kuo LJ,Lin YK,Chang CC,Tai CJ,Chiou JF,Chang YJ.. Clinical outcomes of robot-assisted intersphincteric resection for low rectal cancer: comparison with conventional laparoscopy and multifactorial analysis of the learning curve for robotic surgery. . Int J Colorectal Dis. .2014 ;(29):555-562

55. 2013 Hung CS, ,Liu HH, ,Liu JJ, ,Yeh CT, ,Chang TC, ,Wu CH, Ho YS, Wei PL, Chang YJ. MicroRNA-200a and -200b mediated hepatocellular carcinoma cell migration through the epithelial to mesenchymal transition markers. . Ann Surg Oncol. .2013 ;(20 ):S360-S368

56. 2013 Chen LM, Wang W,Lee JC,Chiu FH,Wu CT,Tai CJ,Wang CK, Tai CJ, Huang MT, Chang YJ. Thrombomodulin mediates the progression of epithelial ovarian cancer cells. . Tumor Biology .2013 ;(00):0-1

57. 2013 Huang HC,Chang TM,Chang YJ,Wen HY. UVB irradiation regulates ERK1/2- and p53-dependent thrombomodulin expression in human keratinocytes. . PLOS ONE .2013 ;(8):e67632-e67641

58. 2013 Tai CJ,Wang CK,Tai CJ,Lin YF,Lin CS,Jian JY, Chang YJ, Chang CC. Aqueous Extract of Solanum nigrum Leaves Induces Autophagy and Enhances Cytotoxicity of Cisplatin, Doxorubicin, Docetaxel, and 5-Fluorouracil in Human Colorectal Carcinoma Cells. . Evid Based Complement Alternat Med. .2013 ;(00):514719-514721

59. 2013 Kuo LJ,Hung CS,Chen WY,Chang YJ,Wei PL. Glucose-regulated protein 78 silencing down-regulates vascular endothelial growth factor/vascular endothelial growth factor receptor 2 pathway to suppress human colon cancer tumor growth. . J Surg Res. 2013 May 29 .2013 ;(13):472-4721

60. 2013 Liang HH,Wei PL,Hung CS,Wu CT,Wang W,Huang MT, Chang YJ. MicroRNA-200a/b influenced the therapeutic effects of curcumin in hepatocellular carcinoma (HCC) cells . Tumor Biology .2013 ;(34):3209-3218

61. 2013 Lai KP,Huang CK,Chang YJ,Chung CY,Yamashita S,Li L, Lee SO, Yeh S, Chang C. New therapeutic approach to suppress castration-resistant prostate cancer using ASC-J9 via targeting androgen receptor in selective prostate cells. . Am J Pathol .2013 ;(182):460-73

62. 2013 Tai CJ,Wang WC,Wang CK,Wu CH,Yang MD,Chang YJ, Jian JY, Tai CJ.. Fermented wheat germ extract induced cell death and enhanced cytotoxicity of Cisplatin and 5-Fluorouracil on human hepatocellular carcinoma cells. . Evid Based Complement Alternat Med .2013 ;(0):121725-0

63. 2013 Kuo LJ,Hung CS,Wang W,Tam KW,Lee HC,Liang HH, Chang YJ, Huang MT, Wei PL.. Intersphincteric resection for very low rectal cancer: clinical outcomes of open versus laparoscopic approach and multidimensional analysis of the learning curve for laparoscopic surgery. . J Surg Res. .2013 ;(183):524-530

64. 2013 Wu CT, Wang WC,Chen MF,Su HY,Chen WY,Wu CH,Chang YJ, Liu HH. Glucose-regulated protein 78 mediates hormone-independent prostate cancer progression and metastasis through maspin and COX-2 expression . Tumor Biology .2013 ;(1):1-1

65. 2013 Tai CJ, Wang JW,,Su HY,Tai CJ,Wang CK,Wu CT,Lien YC, Chang YJ.. Glucose-regulated protein 94 modulates the therapeutic efficacy to taxane in cervical cancer cells. . Tumor Biology .2013 ;(0):1-3

66. 2013 Wei PL,Tu CC,Chen CH,Ho YS,Wu CT,Su HY, Chen WY, Liu JJ, Chang YJ.. Shikonin Suppresses the Migratory Ability of Hepatocellular Carcinoma Cells. . J Agric Food Chem. .2013 ;(00):1-9

67. 2012 Wei PL,Kuo LJ,Wang W,Lin FY,Liu HH,How T, Ho YS, Huang MT, Wu CH, Chang YJ.. Silencing of Glucose-Regulated Protein 78 (GRP78) Enhances Cell Migration Through the Upregulation of Vimentin in Hepatocellular Carcinoma Cells . Ann Surg Oncol. .2012 ;(19):572-579

68. 2012 Wang W,Chin-Sheng H,Kuo LJ,Wei PL,Lien YC,Lin FY, Liu HH, Ho YS, Wu CH, Chang YJ.. NNK Enhances Cell Migration through α7-nicotinic Acetylcholine Receptor Accompanied by Increased of Fibronectin Expression in Gastric Cancer. . Ann Surg Oncol. .2012 ;(19):580-588

69. 2012 Kuo LJ,Chiou JF,Tai CJ,Chang CC,Kung CH,Lin SE, Hung CS, Wang W, Tam KW, Lee HC, Liang HH, Chang YJ, Wei PL. Can we predict pathologic complete response before surgery for locally advanced rectal cancer treated with preoperative chemoradiation therapy? . International Journal of Colorectal Disease .2012 ;(27):613-621

70. 2012 Tai CJ,Chen HA,Chin-Sheng Hung,Kuo LJ,Wei PL,Lu HH,Liu TZ, Liu JJ, Liu DZ, Ho YS, Wu CH, Chang YJ. Survivin-Mediated Cancer Cell Migration Through GRP78 and Epithelial-Mesenchymal Transition (EMT) Marker Expression in Mahlavu Cells. . Annals of surgical oncology .2012 ;(19):336-343

71. 2012 Hung CS,Lin SF,Liu HH,Kuo LJ,Li LT,Su HY, Liew PL, Lin FY, Wei PL, Liu DZ, Chang YJ.. Survivin-mediated Therapeutic Efficacy of Gemcitabine through Glucose-regulated Protein 78 in Hepatocellular Carcinoma . Ann Surg Oncol .2012 ;(8):2744-2752

72. 2012 Chang YJ,Huang YP,Li ZL,Chen CH. GRP78 knockdown enhances apoptosis via the down-regulation of oxidative stress and Akt pathway after epirubicin treatment in colon cancer DLD-1 cells . PLoS ONE .2012 ;(4):e35123

73. 2012 Hung CS,Liu HH,Huang MT,Cheng CW,Kuo LJ,Ho YS, Wu CH, Chen CM, Wei PL, Chang YJ. Knockdown survivin expression reduces the efficacy of curcumin treatment in hepatocellular carcinoma cells . Ann Surg Oncol .2012 ;(11):3547-55

74. 2012 Hung CS,Liu HH,Liu JJ,Yeh CT,Chang TC,Wu CH, Ho YS, Wei PL, Chang YJ. MicroRNA-200a and -200b Mediated Hepatocellular Carcinoma Cell Migration Through the Epithelial to Mesenchymal Transition Markers . Ann Surg Oncol .2012

75. 2012 Huang CY,Shih CM,Tsao NW,Chen YH,Li CY,Chang YJ, Chang NC, Ou KL, Lin CY, Lin YW, Nien CH, Lin FY. GroEL1, from Chlamydia pneumoniae, induces vascular adhesion molecule 1 expression by p37(AUF1) in endothelial cells and hypercholesterolemic rabbit . PLoS One .2012 ;(8):e42808

76. 2012 Huang CY,Lin FY,Shih CM,Au HK,Chang YJ,Nakagami H, Morishita R, Chang NC, Shyu KG, Chen JW. Moderate to high concentrations of high-density lipoprotein from healthy subjects paradoxically impair human endothelial progenitor cells and related angiogenesis by activating Rho-associated kinase pathways . Arterioscler Thromb Vasc Biol .2012 ;(10):2405-2417

77. 2012 Tai CJ,Wang CK,Chang YJ,Lin CS,Tai CJ. Aqueous Extract of Solanum nigrum Leaf Activates Autophagic Cell Death and Enhances Docetaxel-Induced Cytotoxicity in Human Endometrial Carcinoma Cells. . Evid Based Complement Alternat Med. .2012

78. 2011 Kuo LJ,Hung CS,Wu CH,Wang W,Tam KW,Liang HH, Chang YJ, Wei PL. Oncological and Functional Outcomes of Intersphincteric Resection for Low Rectal Cancer. . Journal of surgical Research .2011 ;(1):93-98

79. 2011 Wei PL,Kuo LJ,Huang MT,Ting WC,Ho YS,Wang W, An J, Chang YJ. Nicotine enhances colon cancer cell migration by induction of fibronectin . Annals of Surgical Oncology .2011 ;(6):1782-1790

80. 2011 Chen CH,Chang YJ,Ku MSB,Chung KT,Yang JT. Enhancement of temozolomide-induced apoptosis by valproic acid in human glioma cell lines through the mechanisms of redox regulation . J Mol Med .2011 ;(3):303-315

81. 2011 Chang YJ,Tai CJ,Kuo LJ,Wei PL,Liang HH,Liu TZ, Wang W, Tai CJ, Ho YS, Wu CH, Huang MT.. Glucose-Regulated Protein 78 (GRP78) Mediated the Efficacy to Curcumin Treatment on Hepatocellular Carcinoma. . Annals of Surgical Oncology .2011 ;(8):2395-2403

82. 2011 Lien YC,Wang W,Kuo LJ,Liu JJ,Wei PL,Ho YS, Ting WC, Wu CH, Chang YJ.. Nicotine Promotes Cell Migration Through Alpha7 Nicotinic Acetylcholine Receptor in Gastric Cancer Cells. . Annals of surgical oncology .2011 ;(9):2671-2679

83. 2011 Lin FY,Lin YW,Huang CY,Chang YJ,Tsao NW,Chang NC, Ou KL, Chen TL, Shih CM, Chen YH.. GroEL1, a Heat Shock Protein 60 of Chlamydia pneumoniae, Induces Lectin-Like Oxidized Low-Density Lipoprotein Receptor 1 Expression in Endothelial Cells and Enhances Atherogenesis in Hypercholesterolemic Rabbits. . J immunology .2011 ;(7):4405-4414

84. 2011 Po-Li Wei,Shyr-Yi Lin,Yu-Jia Chang. Cigarette Smoking and Colorectal Cancer: From Epidemiology to Bench . Journal of Experimental & Clinical Medicine .2011 ;(6):257-261

85. 2011 Chin-Sheng Hung,Yu-Jin Peng,Po-Li Wei,Chia-Hwa Lee,Hou-Yu Su,Yuan-Soon Ho,Chih-Hsiung Wu,Yu-Jia Chang. The alpha9 Nicotinic Acetylcholine Receptor is the Key Mediator in Nicotine-enhanced Cancer Metastasis in Breast Cancer Cells . Journal of Experimental and Clinical Medicine .2011 ;(6):283-292

86. 2010 Lee CH,Huang CS,Chen CS,Tu SH,Wang YJ,Chang YJ, Tam KW, Wei PL, Cheng TC, Chu JS, Chen LC, Wu CH, Ho YS.. Overexpression and activation of the alpha9-nicotinic receptor during tumorigenesis in human breast epithelial cells. . J Natl Cancer Inst. .2010 ;(17):1322-1335

87. 2010 Chen CS,Lee CH,Hsieh CD,Ho CT,Pan MH,Huang CS, Tu SH, Wang YJ, Chen LC, Chang YJ, Wei PL, Yang YY, Wu CH, Ho YS.. Nicotine-induced human breast cancer cell proliferation attenuated by garcinol through down-regulation of the nicotinic receptor and cyclin D3 proteins. . Breast Cancer Res Treat. .2010 ;(1):73-87

88. 2010 Tu SH,Ku CY,Ho CT,Chen CS,Huang CS,Lee CH, Chen LC, Pan MH, Chang HW, Chang CH, Chang YJ, Wei PL, Wu CH, Ho YS. Tea polyphenol (-)-epigallocatechin-3-gallate inhibits nicotine- and estrogen-induced α9-nicotinic acetylcholine receptor upregulation in human breast cancer cells . Mol Nutr Food Res .2010 ;(3):455-466

89. 2010 Tung JN,Cheng YW,Hsu CH,Liu TZ,Hsieh PY,Ting LL, Ko HL, Chang YJ, Chiou JF, Wu AT. Normoxically overexpressed hypoxia inducible factor 1-alpha is involved in arsenic trioxide resistance acquisition in hepatocellular carcinoma . Ann Surg Oncol .2010 ;(5):1492-1500

90. 2010 Lee CH,Chang YC,Chen CS,Tu SH,Wang YJ,Chen LC, Chang YJ, Wei PL, Chang HW, Chang CH, Huang CS, Wu CH, Ho YS. Crosstalk between nicotine and estrogen-induced estrogen receptor activation induces α9-nicotinic acetylcholine receptor expression in human breast cancer cells . Breast Cancer Res Treat .2010 ;(2):331-345

91. 2010 Chang YJ,Chiu CC,Wu CH,An J,Wu CC,Liu TZ, Wei PL, Huang MT.. Glucose-Regulated Protein 78 (GRP78) Silencing Enhances Cell Migration but Does Not Influence Cell Proliferation in Hepatocellular Carcinoma. . Ann Surg Oncol. .2010 ;(6):1703-1709

92. 2010 Chiou JF, Tai CJ,Huang MT,Wei PL,Wang YH,An J,Wu CH, Liu TZ, Chang YJ. Glucose-regulated protein 78 is a novel contributor to acquisition of resistance to sorafenib in hepatocellular carcinoma. . Ann Surg Oncol .2010 ;(2):603-612

93. 2010 Huang MT,Wei PL,Liu JJ,Huang HC,An J,Wu CC, Wu CH, Yang YY, Chang YJ. Knockdown of thrombomodulin enhances HCC cell migration through increase of ZEB1 and decrease of E-cadherin gene expression. . Annals of surgical oncology .2010 ;(12):3379-3385

94. 2010 Chen MF,Chen WC,Chang YJ,Wu CF,Wu CT. Role of DNA methyltransferase 1 in hormone-resistant prostate cancer. . J Mol Med. .2010 ;(9):953-962

95. 2009 Wei PL,Chang YJ,Ho YS,Lee CH,Yang YY,Lin SY. Tobacco-specific carcinogen enhances colon cancer cell migration through alpha7-nicotinic acetylcholin receptor . Ann Surg .2009 ;(6):978-985

96. 2008 Chen LM,Wang RS,Lee YF,LiuNC,Chang YJ,Wu CC, Xia S, Hung YC, Chang C. Subfertility with Defective Folliculogenesis in Female Mice Lacking Testicular Orphan Nuclear Receptor 4 . Molecular Endocrineology .2008 ;(4):858-867

97. 2008 Chang PC,Chang YJ,Wu HL,Chang CW,Lin CI,Wang WC, Shi GY. Mutation of human plasminogen kringle 1-5 enhances anti-angiogenic action via increased interaction with integrin alpha(v)beta(3). . Thromb Haemost. 2008 Apr;99(4):729-38. .2008 ;(99):729-738

98. 2007 Yang Z, Chang YJ,,Miyamoto H,,Ni J,,Niu Y,,Chen Z,,Chen YL, Yao JL, di Sant'Agnese PA, Chang C.. Transgelin functions as a suppressor via inhibition of ARA54-enhanced androgen receptor transactivation and prostate cancer cell growth. . Molecular endocrinology .2007 ;(2):343-358

99. 2007 Yang Z, Chang YJ,Yu IC,,Yeh S,,Wu CC,,Miyamoto H,,Merry DE, Sobue G, Chen LM, Chang SS, Chang C.. ASC-J9 ameliorates spinal and bulbar muscular atrophy phenotype via degradation of androgen receptor. . Nature Medicine .2007 ;(3):348-353

100. 2007 Miyamoto H,Yang Z,Chen YT,,Ishiguro H,,Uemura H,,Kubota Y, Nagashima Y, Chang YJ, Hu YC, Tsai MY, Y. Promotion of bladder cancer development and progression by androgen receptor signals. . Journal of the National Cancer Institute .2007 ;(99):558-568

101. 2006 Yang Z, Chang YJ,Miyamoto H,,Yeh S,Yao JL,,di Sant'Agnese PA,,Tsai MY, Chang C. Suppression of androgen receptor transactivation and prostate cancer cell growth by heterogeneous nuclear ribonucleoprotein A1 via interaction with androgen receptor coregulator ARA54. . Endocrinology. .2006 ;(3):1340-1349

102. 2006 Zhang C, Yeh S,,Chen YT,,Wu CC,,Chuang KH,,Lin HY,,Wang RS, Chang YJ, Mendis-Handagama C, Hu L, Lardy. Oligozoospermia with normal fertility in male mice lacking the androgen receptor in testis peritubular myoid cells. . Proc Natl Acad Sci U S A. .2006 ;(103):17718-17723

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