梁有志(Liang, Yu-Chih)　教授

Email
ycliang@tmu.edu.tw
現   職
醫學檢驗暨生物技術學系 教授

學經歷

學　歷

畢業學校與學位[修業時間]
國立臺灣大學生化學研究所 博士
1995/09/01~1999/01/01
國立臺灣大學生化學研究所 碩士
1993/09/01~1995/06/01
私立高雄醫學院醫學技術學系 學士
1986/09/01~1990/06/01

本校學術經歷

任職單位與職稱[起迄時間]
醫學檢驗暨生物技術學系教授
2011/02/01~
醫學檢驗暨生物技術學系(舊)教授
2008/08/01~2011/01/31
醫學檢驗暨生物技術學系(舊)副教授
2006/08/01~2008/07/31
醫事技術學系副教授
2005/02/01~2006/07/31
醫事技術學系助理教授
2003/09/01~2005/01/31
內科學科助理教授
2000/08/01~2003/08/31

本校兼職教學行政經歷

服務單位與職稱[起迄時間]
教務處副教務長
2023/07/08 ~ 2023/07/31
教務處副教務長
2023/01/16 ~ 2023/02/15
教學資源中心代理主任
2021/12/22 ~ 2022/01/31
教師發展中心主任
2020/11/16 ~ 2022/07/31
教學資源中心代理主任
2020/03/01 ~ 2020/04/30
教務處教務長
2019/08/01 ~ 2023/07/31
(舊)教學評量委員會主任委員
2019/08/01 ~ 2023/07/31
人體研究處人研長
2017/08/01 ~ 2019/07/31
(舊)生技醫療產業研發博士學位學程教授
2016/08/01 ~ 2017/07/31
醫學生物科技博士學位學程主任
2015/08/01 ~ 2017/07/31
醫學生物科技博士學位學程籌備處副教授
2015/02/01 ~
醫學生物科技博士學位學程籌備處主任
2014/11/01 ~ 2015/07/31
醫學科學研究所
2013/02/01 ~
醫學檢驗暨生物技術學系主任
2011/08/01 ~ 2017/07/31
實驗動物中心主任
2009/08/01 ~ 2011/09/30
醫學科學研究所副教授
2007/08/01 ~

其它經歷

任職單位與職稱[起迄時間]
國立臺灣大學博士後研究
1999/01/01~2000/07/31
臺灣大學醫學院附設醫院檢驗學科血液室專任助理
1992/08/01~1993/08/31

專長與研究領域

學門領域
Tumor biology
Molecular biology
Signal transduction
Functional assay of natural products
寄生蟲學、醫事技術及實驗診斷
學術專長
Nude Mice Xenograft Tumor Models
Animal cell culture
Two-dimensional Electrophoresis
Protein Kinase Activity Assay
Site-directed mutagenesis

論文著作

清冊下載

論文 Journal Paper


1. 2023 Pan-inhibition of protein disulfide isomerase caused cell death through disrupting cellular proteostasis in pancreatic ductal adenocarcinoma cells . Inter. J. Mol. Sci. Accept. .2023

2. 2022 H1-Antihistamines Reduce the Risk of Hepatocellular Carcinoma in Patients With HBV, HCV, or Dual HBV-HCV Infection . J Clin. Oncol. online publish .2022 ;(40):1206-1219

3. 2022 Chang CC,Lee KL,Chan TS,Chung CC,Liang YC. Histone deacetylase inhibitors downregulate calcium pyrophosphate crystal formation in human articular chondrocytes. . Int. J. Mol. Sci. .2022 ;(23):2604

4. 2022 Differential impact of the rpob mutant on rifampin and rifabutin resistance signatures of Mycobacterium tuberculosis is revealed using a whole-genome sequencing assay . Microbiol Spectr .2022 ;(10):e0075422

5. 2021 MCPIP1 Enhances TNF-alpha-Mediated Apoptosis through Downregulation of the NF-kappaB/cFLIP Axis . Biology (Basel) .2021 ;(10):655

6. 2021 Integrative utility of long read sequencing-based whole genome analysis and phenotypic assay on differentiating isoniazid-resistant signature of Mycobacterium tuberculosis . J. Biomed. Sci. .2021 ;(28):86

7. 2020 The antihistamine deptropine induces hepatoma cell death through blocking autophagosome-lysosome fusion. . Cancers (Basel) .2020 ;(12):E1610

8. 2020 Hsiao YP,Chen HT,Liang YC,Wang TE,Huang KH,Hsu CC, Liang HJ, Huang CH, Jan TR. Development of nanosome-encapsulated honokiol for intravenous therapy against experimental autoimmune encephalomyelitis . International Journal of Nanomedicine .2020 ;(15):17-29

9. 2020 Chang TC,Chiou WC,Lai WH,Huang HC,Huang YL,Liu HK, Liang YC, Huang C. Ugonin J improves metabolic disorder and ameliorates nonalcoholic fatty liver disease by regulating the AMPK/AKT signaling pathway . Pharmacological Research .2020 ;(163)

10. 2019 Chang TC,Chiang H,Lai YH,Huang YL,Huang HC,Liang YC, Liu HK, Huang C. . Helminthostachys zeylanica alleviates hepatic steatosis and insulin resistance in diet-induced obese mice . BMC Complementary and Alternative Medicine .2019 ;(19):368

11. 2018 RBM4a-SRSF3-MAP4K4 Splicing Cascade Constitutes a Molecular Mechanism for Regulating Brown Adipogenesis . Int J Mol Sci .2018 ;(19):2646

12. 2018 ZFP36L1 and ZFP36L2 inhibit cell proliferation in a cyclin D-dependent and p53-independent manner . Sci Reports .2018 ;(8):2742

13. 2018 Suk FM,Chang CC,Lin RJ,Lin SY,Chen YT,Liang YC. MCPIP3 as a Potential Metastasis Suppressor Gene in Human Colorectal Cancer . Int. J. Mol. Sci. 2018, 19, 1350 .2018 ;(19):1350-1361

14. 2017 Leung W,Ho FM,Li WP,Liang YC. Vitis thunbergii var. taiwaniana leaf extract reduces blood glucose levels in mice with streptozotocin-induced diabetes . Int J Pharmacol. .2017 ;(13):457-464

15. 2016 Chin LH,Hsu SP,Zhong WB,Liang YC. Involvement of cysteine-rich protein 61 in the epidermal growth factor-induced migration of human anaplastic thyroid cancer cells . Mol Carcinogenesis .2016 ;(55):622-632

16. 2015 Chang CC,Tsai YH,Liu Y,Lin SY,Liang YC. Calcium-containing crystals enhance receptor activator of nuclear factor kB ligand/macrophage colony-stimulating factor-mediated osteoclastogenesis via extracellular-signal-regulated kinase and p38 pathways . Rheumatology .2015 ;(54):1913-1922

17. 2015 Lee WH,Wu HH,Huang WJ,Li YN,Lin RJ,Lin SY, Liang YC. N-Hydroxycinnamide Derivatives of Osthole Ameliorate Hyperglycemia through Activation of AMPK and p38 MAPK . Molecules .2015 ;(20):4516-4529

18. 2015 Liang YC,Lin WC,Lin YJ,Lin JC. The impact of RNA binding motif protein 4-regulated splicing cascade on the progression and metabolism of colorectal cancer cells . Oncotarget. 2015 Oct 19 .2015

19. 2015 Liu JJ,Wu HH,Chen TH,Leung W,Liang YC. 15,16-Dihydrotanshinone I from the functional food Salvia miltiorrhiza exhibits anticancer activity in human leukemia cells: in vitro and in vivo studies . Int J Mol Sci. .2015 ;(16):19387-19400

20. 2015 Suk FM,Lin SY,Lin RJ,Hsine YH,Liao YJ,Fang SH, Liang YC. Bortezomib inhibits Burkitt’s lymphoma cell proliferation by downregulating sumoylated hnRNP K and c-Myc expression . Oncotarget .2015 ;(6):25988-26001

21. 2015 Liao YJ,Fang CC,Yen CH,Hsu SM,Wang CK,Huang SF, Liang YC, Lin YY, Chu YT, Arthur Chen YM. Niemann-Pick Type C2 protein regulates liver cancer progression via modulating ERK1/2 pathway: Clinicopathological correlations and therapeutical implications. . Int J Cancer. 2015 Mar 6. doi: .2015

22. 2015 Chin LH,Hsu SP,Zhong WB,YC Liang. Combined treatment with troglitazone and lovastatin inhibited epidermal growth factor-induced migration through the downregulation of cysteine-rich protein 61 in human anaplastic thyroid cancer cells. . PLOS ONE .2015 ;(10):e01186

23. 2014 Liu LY,Huang WJ,Ho FM,Lin RJ,Lin SY,Suk FM, Liang YC. N-Hydroxycinnamide derivatives of osthole inhibit cell migration and invasion by suppressing Smad2 and Akt pathways in human colorectal adenocarcinoma cells. . Chem Biol Interact .2014 ;(217):1-8

24. 2014 Lin RJ,Chu JS,Chien HL,Tseng CH,Ko PC,Mei YY, Tang WC, Kao YT, Cheng HY, Liang YC, Lin SY. MCPIP1 Suppresses Hepatitis C Virus Replication and Negatively Regulates Virus-induced Proinflammatory Cytokine Responses . J Immunol .2014 ;(193):4159-4168

25. 2013 Suk FM,Jou WJ,Lin RJ,Lin SY,Tzeng FY,Liang YC. 15,16-Dihydrotanshinone I-induced Apoptosis in Human Colorectal Cancer Cells: Involvement of ATF3. . Anticancer Res. .2013 ;(33):3225-3231

26. 2013 Wu SS,Chen LG,Lin RJ,Lin SY,Lo YE,Liang YC. Cytotoxicity of (-)-vitisin B in human leukemia cells. . Drug Chem Toxicol .2013 ;(36):313-319

27. 2013 Suk FM,Lien GS,Huang WJ,Chen CN,Lu SY,Yang YC, Yan MD, Liang YC. A Taiwanese propolis derivative induces apoptosis through inducing endoplasmic reticular stress and activating transcription factor-3 in human hepatoma cells. . Evid Based Complement Alternat Med. .2013 ;(2013):658370

28. 2013 Liu LY,Huang WJ,Lin RJ,Lin SY,Liang YC. N-hydroxycinnamide derivatives of osthole presenting genotoxicity and cytotoxicity against human colon adenocarcinoma cells in vitro and in vivo. . Chem Res Toxicol. .2013 ;(26):1683-1691

29. 2012 Keller JJ,Liang YC,Lin HC. Association between multiple sclerosis and erectile dysfunction: a nationwide case-control study. . J Sex Med. .2012 ;(9):1753-1759

30. 2012 Huang WJ,Liang YC,Chuang SE,Chi LL,Lee CY,Lin CW, Chen AL, Huang JS, Chiu CJ, Lee CF, Huang CY, Chen CN. NBM-HD-1: a Novel Histone Deacetylase Inhibitor with Anticancer Activity . Evid Based Complement Alternat Med. .2012

31. 2012 Chung SD,Keller JJ,Liang YC*,Lin HC*. Association Between Viral Hepatitis and Erectile Dysfunction: A Population-Based Case-Control Analysis . J Sex Med. [Epub ahead of print] .2012 ;(x):1-8

32. 2012 Chien CS,Ho HO,Liang YC,Ko PH,Sheu MT,Chen CH. Incorporation of exudates of human platelet-rich fibrin gel in biodegradable fibrin scaffolds for tissue engineering of cartilage . J Biomed Mater Res B Appl Biomater. .2012 ;(100):948-955

33. 2012 Shing-Sheng Wu,Lih-Geeng Chen,Ren-Jye Lin,Shyr-Yi Lin,Yueh-E Lo,Yu-Chih Liang. Cytotoxicity of (-)-vitisin B in human leukemia cells . Drug and Chemical Toxicology, In press .2012

34. 2011 Chuang MT,Ho FM,Wu CC,Zhuang SY,Lin SY,Suk FM, Liang YC. 15,16-Dihydrotanshinone I, a compound of Salvia miltiorrhiza Bunge, induces apoptosis through inducing endoplasmic reticular stress in human prostate carcinoma cells . Evid Based Complement Alternat Med., .2011 ;(2011):865435-865445

35. 2011 Lee WH,Lin RJ,Lin SY,Chen YC,Lin HM,Liang YC. Osthole increases glucose uptake through activation of AMP-activated protein kinase in skeletal muscle cells. . J Agric Food Chem. .2011 ;(59):12874-12881

36. 2011 Chen CH,Chien MY,Liang YC,Liu DZ,Hu ML. An in vitro hyperbaric oxygen system for evaluation of free radical damage and protection by catechins on hemorheological parameters . Clin Hemorheol Microcirc .2011 ;(48):211-221

37. 2011 Zhong WB,Hsu SP,Ho PY,Liang YC,Chang TC,Lee WS. Lovastatin inhibits proliferation of anaplastic thyroid cancer cells through up-regulation of p27 by interfering with the Rho/ROCK-mediated pathway . Biochem Pharmacol .2011 ;(82):1663-1672

38. 2011 Wei JD,Tseng H,Chen ET,Hung CH,Liang YC,Sheu MT, Chen CH. Characterizations of Chondrocyte Attachment and Proliferation Scaffolds of PLLA and PBSA for Use in Cartilage Tissue Engineering . J Biomater Appl. In press. .2011

39. 2011 Chang CJ,Yang YH,Liang YC,Chiu CJ,Chu KH,Chou HN, Chiang BL.. A novel phycobiliprotein alleviates allergic airway inflammation by modulating immune responses. . Am J Respir Crit Care Med. .2011 ;(183):15-25

40. 2010 Li-Ching Lin,Feng-Ming Ho,Shish-Jung Yen,Pei-Yi Wu,Ling-Fang Hung,Wei-Jan Huang, Yu-Chih Liang. Carbon monoxide induces cyclooxygenase-2 expression through MAPKs and PKG in phagocytes . International Immunopharmacology .2010 ;(10):1520-1525

41. 2010 Chien MH,Lee TS,Liang YC,Lee WS. beta-Sitosterol Inhibits Cell Cycle Progression of Rat Aortic Smooth Muscle Cells through Increases of p21(cip1) Protein. . J Agric Food Chem. .2010 ;(58):10064-10069

42. 2010 Wang LC,Chu KH,Liang YC,Lin YL,Chiang BL. Caffeic acid phenethyl ester inhibits nuclear factor-kappaB and protein kinase B signalling pathways and induces caspase-3 expression in primary human CD4+ T cells. . Clin Exp Immunol. .2010 ;(160):223-232

43. 2010 Wang CK,Chen LG,Wen CL,Hou WC,Hung LF,Yen SJ, Shen YJ, Lin SY, Liang YC. Neuroprotective Activity of Vitis thunbergii var. taiwaniana Extracts in vitro and in vivo. . J Med Food. .2010 ;(13):170-178

44. 2009 Chen CH,Song TY,Liang YC,Hu ML. Acteoside and 6-O-acetylacteoside downregulate cell adhesion molecules induced by IL-1beta through inhibition of ERK and JNK in human vascular endothelial cells. . J Agric Food Chem57(19):8852-9 .2009 ;(57):8852-8859

45. 2009 Hsu SP,Ho PY,Liang YC,Ho YS,Lee WS. Involvement of the JNK activation in terbinafine-induced p21 up-regulation and DNA synthesis inhibition in human vascular endothelial cells. . J Cell Biochem .2009 ;(108):860-866

46. 2009 Chen LC,Liu YC,Liang YC,Ho YS,Lee WS. Magnolol Inhibits Human Glioblastoma Cell Proliferation through Upregulation of p21/Cip1. . J Agric Food Chem. .2009 ;(57):7331-7337

47. 2009 Wang LC,Lin YL,Liang YC,Yang YH,Lee JH,Yu HH, Wu WM, Chiang BL.. he effect of caffeic acid Phenethyl Ester on the functions of human monocyte-derived dendritic cells. . BMC Immunol. .2009 ;(10):39

48. 2009 Liang HJ,Suk FM,Wang CK,Hung LF,Liu DZ,Chen NQ, Chen YC, Chang CC, Liang YC. Osthole, a potential antidiabetic agent, alleviates hyperglycemia in db/db mice. . Chem-Biol Interact. .2009 ;(181):309-315

49. 2009 Lin YL,Liang YC,Tseng YS,Huang HY,Chou SY,Hseu RS, Huang CT, Chiang BL. An immunomodulatory protein, Ling Zhi-8, induced activation and maturation of human monocyte-derived dendritic cells by the NF-{kappa}B and MAPK pathways. . J Leukoc Biol. 86(4):877-889 .2009 ;(86):877-889

50. 2009 Suk FM,Chen CH,Lin SY,Cheng CJ,Yen SJ,Hung LF, Liu DZ, Liang YC. 15-deoxy-Delta(12,14)-prostaglandin J(2) inhibits fibrogenic response in human hepatoma cells. . Toxicol Lett. .2009 ;(187):22-27

51. 2009 Wang AM,Ku HH,Liang YC,Chen YC,Hwu YM,Yeh TS. The autonomous notch signal pathway is activated by baicalin and baicalein but is suppressed by niclosamide in K562 cells. . J Cell Biochem. .2009 ;(106):682-692

52. 2008 #Lin YC,#Liang YC,Sheu MT,Lin YC,Hsieh MS,Chen TF, Chen CH.. Chondroprotective effects of glucosamine involving the p38 MAPK and Akt signaling pathways. . Rheumatol Int. .2008 ;(28):1009-1016

53. 2008 Lu HT#,Liang YC#,Sheu MT,Ho HO,Lin YT,Hsieh MS, Chen CH. Disease-modifying effects of glucosamine HCl involving regulation of metalloproteinases and chemokines activated by interleukin-1β in human primary synovial fibroblasts. . J. Cell. Biochem. .2008 ;(104):38-50

54. 2008 Ho PY,Hsu SP,Liang YC,Kuo ML,Ho YS,Lee WS. Inhibition of the ERK phosphorylation plays a role in terbinafine-induced p21 up-regulation and DNA synthesis inhibition in human vascular endothelial cells. . Toxicol. Appl. Pharmacol. .2008 ;(229):86-93

55. 2008 Chen SH,Lin JK,Liang YC,Pan MH,Liu SH,Lin-Shiau SY. Involvement of activating transcription factors JNK, NF-kappaB, and AP-1 in apoptosis induced by pyrrolidine dithiocarbamate/Cu complex. . Eur J Pharmacol. .2008 ;(594):9-17

56. 2008 Hsu SP,Ho PY,Juan SH,Liang YC,Lee WS. Progesterone inhibits human endothelial cell proliferation through a p53-dependent pathway. . Cell Mol Life Sci. .2008 ;(65):3839-3850

57. 2008 Liu Y,Wu J,Ho PY,Chen LC,Chen CT,Liang YC, Cheng CK, Lee WS.. Anti-angiogenic action of 5,5-diphenyl-2-thiohydantoin-N10 (DPTH-N10). . Cancer Lett. .2008 ;(271):294-305

58. 2008 Chen SH,Lin JK,Liu SH,Liang YC,Lin-Shiau SY. Apoptosis of Cultured Astrocytes Induced by the Copper and Neocuproine Complex Through Oxidative Stress and JNK Activation. . Toxicol Sci. .2008 ;(102):138-149

59. 2008 Fat-Moon SUK,Shyr-Yi LIN,Chien-Ho CHEN,Shish-Jung YEN,Ching-Hua SU,Der-Zen LIU, Wen-Chi HOU, Ling-Fang HUNG,. Taiwanofungus camphorate activates peroxisome proliferator-activated receptors and induces hypotriglyceride in hypercholesterolemic rats . Bioscience,Biotechnology,and Biochemistry .2008 ;(72):1704-1713

60. 2008 Chang CC,Liu DZ,Lin SY,Liang HJ,Hou WC,Huang WJ, Chang CH, Ho FM, Liang YC.. Liposome encapsulation reduces cantharidin toxicity. . Food Chem Toxicol. .2008 ;(46):3116-3121

61. 2007 Tsai1 SL,Suk FM,Wang CI,Liu DZ,Hou WC,Lin PJ, Hung LF, Liang YC. Anti-tumor potential of 15,16-dihydrotanshinone I against breast adenocarcinoma through inducing G1 arrest and apoptosis . Biochemical Pharmacology .2007 ;(74):1575-1586

62. 2007 Lo YJ,Sheu MT,Tsai WC,Lin YH,Li JL,Liang YC, Chang CC, Hsieh MS, Chen CH. Intra-articular injection of hyaluronate and indomethacin in rabbits with antigen-induced arthritis. 27: 1099-111. . Rheumatol Int. .2007 ;(27):1099-1111

63. 2007 Liu DZ,Liang HJ,Chen CH,Lin SY,Zhong WB,Ho FM, Hou WC, Lo JL, Ho YS, Lin PJ, Liang YC. Switch activation of PI-PLC downstream signals in activated macrophages with wortmannin. . BBA - Molecular Cell Research. In Press. .2007 ;(1773):869-879

64. 2007 Liu DZ,Liang HJ,Chen CH,Su CH,Lee TH,Huang CT, Hou WC, Lin SY, Zhong WB, Liang YC. Comparative anti-inflammatory characterization of wild fruiting body, liquid-state fermentation, and solid-state culture of Taiwanofungus camphoratus in microglia and the mechanism of its action. . J. Ethnopharmacol. .2007 ;(113):45-53

65. 2007 Lin YL,Liang YC,Chiang BL. Placental growth factor down-regulates type 1 T helper immune response by modulating the function of dendritic cells. . J. Leukoc. Biol. .2007 ;(82):1473-1480

66. 2007 Cheng HC,Chan CM,Tsay HS,Liang HJ,Liang YC,Liu DZ. Improving Effects of Epigallocatechin-3-Gallate on Hemorheological Abnormalities of Aging Guinea Pigs. . Circ. J. .2007 ;(71):597-603

67. 2007 Liu DZ,Liang YC,Lin SY,Lin YS,Wu WC,Hou WC, Su CH. Antihypertensive Activities of a Solid-State Culture of Taiwanofungus camphoratus (Chang-Chih) in Spontaneously Hypertensive Rats. 71(1):23-30. . Biosci Biotechnol Biochem. .2007 ;(71):23-30

68. 2006 Chen CH,Sheu MT,Chen TF,Wang YC,Hou WC,Liu DZ, Chung TC, Liang YC. Suppression of endotoxin-induced proinflammatory responses by citrus pectin through blocking LPS signaling pathways. . Biochem. Pharmacol. .2006 ;(72):1001-1009

69. 2005 Liang YC,Wu CH,Chu JS,Wang CK,Hung LF,Wang YJ, Ho YS, Chang JG and Lin SY. Involvement of Fatty Acid-CoA Ligase 4 in Hepatocellular Carcinoma Growth: Roles of Cyclic AMP and p38 Mitogen-Activated Protein Kinase. . World J. Gastroenter .2005 ;(11):2557-2563

70. 2005 Zhong WB,Liang YC,Wang CY,Chang TC,Lee WS. Lovastatin suppresses invasiveness of anaplastic thyroid cancer cells by inhibiting Rho geranylgeranylation and RhoA/ROCK signaling. . Endocr Relat Cancer. .2005 ;(12):615-629

71. 2005 Lin CM,Huang ST,Liang YC,Lin MS,Shih CM,Chang YC, Chen TY, Chen CT.. Isovitexin suppresses lipopolysaccharide-mediated inducible nitric oxide synthase through inhibition of NF-kappa B in mouse macrophages. 71(8): 748-753. . Planta Med. .2005 ;(71):748-753

72. 2005 Chen SH,Liang YC,Chao JC,Tsai LH,Chang CC,Wang CC, Pan S.. Protective effects of Ginkgo biloba extract on the ethanol-induced gastric ulcer in rats. . World J Gastroenterol. .2005 ;(11):3746-3750

73. 2005 Huang HM,Liang YC,Cheng TH,Chen CH,Juan SH. Potential mechanism of blood vessel protection by resveratrol, a component of red wine. . Ann N Y Acad Sci. .2005 ;(1042):349-356

74. 2005 Yang KC,Uen YH,Suk FM,Liang YC,Wang YJ,Ho YS, Li IH, Lin SY.. Molecular mechanisms of denbinobin-induced anti-tumorigenesis effect in colon cancer cells. 11(20): 3040-3045. . World J Gastroenterol. .2005 ;(11):3040-3045

75. 2005 Lin YL,Liang YC,Lee SS,Chiang BL. Polysaccharide purified from Ganoderma lucidum induced activation and maturation of human monocyte-derived dendritic cells by the NF-kappaB and p38 mitogen-activated protein kinase pathways. . J Leukoc Biol. .2005 ;(78):533-543

76. 2005 Ho YS,Chen CH,Wang YJ,Pestell RG,Albanese C,Chen RJ, Chang MC, Jeng JH, Lin SY, Liang YC, Tsen. Tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces cell proliferation in normal human bronchial epithelial cells through NFkappaB activation and cyclin D1 up-regulation. . Toxicol Appl Pharmacol. .2005 ;(205):133-148

77. 2005 Liang YC,Liu HJ,Chen SH,Tsai LH. Effect of lipopolysaccharide on the diarrhea and the gastrointestinal transit in mice: roles of nitric oxide and prostaglandin E2. . World J. Gastroenter. .2005 ;(21):357-361

78. 2005 Chou YH,Ho FM,Liu DZ,Lin SY,Tsai LH,Chen CH, Ho YS, Hung LF and Liang YC. The possible role of heat shock factor-1 in the negative regulation of heme oxygenase-1. . Inter J Biochem Cell Biol. .2005 ;(37):604-615

79. 2004 Liu JD,Tsai SH,Lin SY,Ho YS,Hung LF,Pan S, Ho FM, Lin CM, Liang YC. Thiol antioxidant and thiol-reducing agents attenuate 15-deoxy-D12,14- prostaglandin J2-induced heme oxygenase-1 expression. . Life Sci .2004 ;(74):2451-2463

80. 2004 Shih CR,Wu J,Liu Y,Liang YC,Lin SY,Sheu MT, Lee WS. Anti-proliferation effect of 5,5-diphenyl-2-thiohydantoin (DPTH) in human vascular endothelial cells. . Biochem. Pharmacol .2004 ;(67):67-75

81. 2004 Ho PY,Liang YC,Ho YS,Chen CT,Lee WS. Inhibition of human vascular endothelial cells proliferation by terbinafine. . Inter. J. Cancer, In press. .2004

82. 2004 Hsu YH,Hsieh MS,Liang YC,Li CY,Sheu MT,Chou DT, Chen TF, Chen CH. Production of the chemokine eotaxin-1 in osteoarthritis and its role in cartilage degradation. . J. Cell. Biochem. .2004 ;(93):929-939

83. 2004 Liao CH,Sang S,Liang YC,Ho CT,Lin JK. Suppression of inducible nitric oxide synthase and cyclooxygenase-2 in downregulating nuclear factor-kappa B pathway by Garcinol. . Molecular Carcinog. .2004 ;(41):140-149

84. 2004 Shih CM,Lin H,Liang YC,Lee WS,Bi WF,Juan SH. Concentration-dependent differential effects of quercetin on rat aortic smooth muscle cells. . Eur J Pharmacol. .2004 ;(496):41-48

85. 2004 Yu CH,Wu J,Su YF,Ho PY,Liang YC,Sheu MT, Lee. Anti-proliferation effect of 3-amino-2-imino-3, 4-dihydro-2H-1,3- benzothiazin-4-one (BJ-601) on human vascular endothelial cells: G0/G1 p21-associated cell cycle arrest. . Biochem Pharmacol. .2004 ;(67):1907-1916

86. 2003 Lee WS, Chen RJ, Wang YJ, Tseng H, Jeng JH, Lin SY, Liang YC, Chen CH, Lin CH, Lin JK, Ho PY, Chu JS, Ho WL, Chen LC, and Ho YS. In vitro and in vivo studies of the anticancer action of terbinafine in human cancer cell lines: G0/G1 p53-associated cell cycle arrest. . Inter. J. Cancer .2003 ;(106):125-137

87. 2003 Hsieh MS, Ho HC, Chou DT, Pan S, Liang YC, Hsieh TY, Lan JL, Tsai SH. Expression of matrix metalloproteinase-9 (gelatinase B) in gouty arthritis and stimulation of MMP-9 by urate crystals in macrophages. . J Cell Biochem. .2003 ;(89):791-799

88. 2003 Hsu HK, Juan SH, Ho PY, Liang YC, Lin CH, Teng CM, Lee WS. YC-1 inhibits proliferation of human vascular endothelial cells through a cyclic GMP-independent pathway. . Biochem Pharmacol. .2003 ;(66):263-271

89. 2003 iu JD, Tsai SH, Lin SY, Ho YS, Hung LF, Pan S, Ho FM, Lin CM and Liang YC. Thiol antioxidant and thiol-reducing agents attenuate 15-deoxy-D12,14- prostaglandin J2-induced heme oxygenase-1 expression. . Life Sci., accepted. .2003

90. 2003 Liu JD, Lin SY, Ho YS, Pan S, Hung LF, Tsai SH, Lin JK and Liang YC. Involvement of c-Jun N-terminal kinase activation in 15-deoxy-D12,14-prostaglandin J2 and prostaglandin A1-induced apoptosis in AGS gastric epithelial cells. . Mol. Carcinogenesis, In Press .2003

91. 2003 Lee WS, Liu CW, Juan SH, Liang YC, Ho PY and Lee YH. Molecular mechanism of progesterone-induced antiproliferation in rat aortic smooth muscle cells. . Endocrinology, In Press. .2003

92. 2003 Liang, Y.C., Tsai, S.H., Chen, L., Lin-Shiau, S.Y. and Lin, J.K.. Resveratrol-induced G2 arrest through inhibition CDK7 and p34CDC2 kinases in colon carcinoma HT29 cells. . Biochem. Pharmacol. .2003 ;(65):1053-1060

93. 2002 Tseng, C.J., Wang, Y.J., Liang, Y.C., Jeng, J.H., Lee, W.S., Lin, J.K., Chen, C.H., Liu, I.C. and Ho, Y.S.. Microtubule damaging agents induce apoptosis in HL 60 cells and G2/M cell cycle arrest in HT 29 cells. . Toxicology .2002 ;(175):123-142

94. 2002 Wu, C.H., Jeng, J.H., Wang, Y.J., Tseng, C.J., Liang, Y.C., Chen, C.H., Lee, H.M., Lin, J.K., Lin, C.H., Lin, S.Y., Li, C.P. and Ho, Y.S.. Antitumor effects of miconazole on human colon carcinoma xenografts in nude mice through induction of apoptosis and G0/G1 cell cycle arrest. . Toxicol Appl Pharmacol .2002 ;(180):22-35

95. 2002 Lin, C.M., Chen, C.S., Chen, C.T., Liang, Y.C. and Lin, J.K.. Molecular modeling of flavonoids that inhibits xanthine oxidase. . Biochem. Biophy. Res. Commun., .2002 ;(294):167-172

96. 2002 Lo, A.H., Liang, Y.C., Lin-Shiau, S.Y., Ho, C.T. and Lin, J.K.. Carnosol, an antioxidant in rosemary, suppresses inducible nitric oxide synthase through down-regulating nuclear factor-kB in mouse macrophages. . Carcinogenesis, .2002 ;(23):983-991

97. 2002 Lin, S.Y., Liang, Y.C., Ho, Y.S., Tsai, S.H., Pan, S. and Lee, W.S.. Involvement of both extracellular signal-regulated kinase and c-Jun N-terminal kinase pathways in the 12-o-tetradecanoylphorbol-13-acetate-induced upregulation of p21Cip1 in colon cancer cells. . Mol. Carcinogenesis, .2002 ;(35):21-28

98. 2002 Wang YJ, Yu CF, Chen LC, Chen CH, Lin JK, Liang YC, Lin CH, Lin SY, Chen CF. and Ho YS.. Ketoconazole potentiates terfenadine-induced apoptosis in human HepG2 cells through inhibition of cytochrome p450 3A4 activity. . J. Cell. Biochem. .2002 ;(87):147-159

99. 2002 Ho YS, Lin JK, Hung LF, Lin SY, Pan S, and Liang YC. Suppression of Leukocyte Adhesion Molecules Through Inhibition of IkB Kinase by Tea Polyphenols in Human Vascular Endothelial Cells. . New Taipei Medical Journal .2002 ;(4):249-254

100. 2002 Yang LL, Liang YC, Chang CW, Lee WS, Kuo CT, Wang CC, Lee HM. and Lin CH.. Effects of sphondin, isolated from Heracleum laciniatum, on IL-1beta-induced cyclooxygenase-2 expression in human pulmonary epithelial cells. . Life Sci. .2002 ;(72):199-213

101. 2002 Wang YJ, Jeng JH, Chen RJ, Tseng H, Chen LC, Liang YC, Lin CH, Chen CH, Chu JS, Ho WL. and Ho YS.. Ketoconazole potentiates the antitumor effects of nocodazole: In vivo therapy for human tumor xenografts in nude mice. . Mol. Carcinogenesis .2002 ;(34):199-210

102. 2002 Tsai, S.H., Liang, Y.C., Chen, L., Ho, F.M., Hsieh, M.S., and Lin, J.K.. Arsenite stimulates cyclooxygenase-2 expression through activating IkB kinase and nuclear factor kB in primary and ECV304 endothelial cells. . J. Cell. Biochem. .2002 ;(84):750-758

103. 2002 Liang, Y.C., Tsai, S.H., Lin-Shiau, S.Y., Chen, C.F. and Lin, J.K.. Inhibition of 12-O-tetradecanoylphorbol-13-acetate-caused ornithine decarboxylase activity in mouse skin by (-)-epigallocatechin-3-gallate and individual theaflavins. . Nutr. Cancer .2002 ;(42):217-223

104. 2001 Ho, Y.S., Duh, J.S., Jeng, J.H., Wang, Y.J., Liang, Y.C., Lin, C.H., Tseng, C.J., Yu, C.F., Chen, R.J., Lin, J.K.. Griseofulvin potentiates antitumorigenesis effects of nocodazole through induction of apoptosis and G2/M cell cycle arrest in human colorectal cancer cells. . Inter. J. Cancer .2001 ;(91):393-401

105. 2001 Tsai, S.H., Hsieh, M.S., Chen, L., Liang, Y.C., Lin, J.K. and Lin, S.Y.. Suppression of Fas ligand expression on endothelial cells by arsenite through reactive oxygen species. . Toxicol. Lett. .2001 ;(123):11-19

106. 2001 Sung Ho Chen , Shing Hwa Liu , Yu-Chih Liang , Jen-Kun Lin , Shoei-Yn Lin-Shiau. Oxidative stress and c-Jun-amino-terminal kinase activation involved in apoptosis of primary astrocytes induced by disulfiram–Cu 2 + complex . European Journal of Pharmacology .2001 ;(414):177-188

107. 2001 Yu-Chih Liang, Shu-Huei Tsai1, De-Cheng Tsai1, Shoei-Yn Lin-Shiau, and Jen-Kun Lin1. Suppression of inducible cyclooxygenase and nitric oxide synthase through activation of peroxisome proliferator-activated receptor-g by flavonoids in mouse macrophages . FEBS Letters .2001 ;(496):12-18

108. 2001 Jean-Dean Liu, Sheng-Hsuan Chen, Chih-Li Lin, Shu-Huei Tsai, and Yu-Chih Liang. Inhibition of Melanoma Growth and Metastasis by Combination with (-)-Epigallocatechin-3-gallate and Dacarbazine in Mice . Journal of Cellular Biochemistry .2001 ;(83):631-642

109. 2000 Ho, Y.S., Duh, J.S., Jeng, J.H., Wang, Y.J., Liang, Y.C., Lin, C.H., Tseng, C.J., Yu, C.F., Chen, R.J., Lin, J.K.. Griseofulvin potentiates antitumorigenesis effects of nocodazole through induction of apoptosis and G2/M cell cycle arrest in human colorectal cancer cells. . Inter. J. Cancer .2000 ;(91):393-401

110. 2000 Chen, R.J., Lee, W.S., Liang, Y.C., Lin, J.K., Wang, Y.J., Lin, C.H., Hsieh, J.Y., Chaing, C.C., Ho, Y.S.. Ketoconazole induces G0/G1 arrest in human colorectal and hepatocellular carcinoma cell lines. . Toxicol. App. Pharmacol. .2000 ;(169):132-141

111. 2000 Pan, M.H., Liang, Y.C., Lin-Shiau, S.Y., Zhu, N.Q., Ho, C.T. and Lin, J.K.. Induction of apoptosis by the oolong tea polyphenol theasinensin a through cytochrome c release and activation of caspase-9 and caspase-3 in human U937 cells. . J. Agric. Food Chem. .2000 ;(48):6337-6346

112. 2000 Lin, J.K. and Liang, Y.C.. Cancer Chemoprevention by Tea Polyphenols- a review. . Proc. Nat. Sci. Coun. .2000 ;(24):1-13

113. 2000 Chen, S.H., Liu, S.H., Liang, Y.C., Lin, J.K. and Lin-Shiau S.Y.. Death signaling pathway induced by pyrrolidine dithiocarbamate-Cu2+ complex in the cultured rat cortical astrocytes. . Glia .2000 ;(31):249-261

114. 1999 Liang, Y.C., Lin-Shiau, S.Y., Chen, C.F. and Lin, J.K.. Inhibition of cyclin-dependent kinases 2 and 4 activities as well as induction of Cdk inhibitors p21 and p27 during growth arrest of human breast carcinoma cells by (-)-epigallocatechin-3-gallate . J. Cell. Biochem. .1999 ;(75):1-12

115. 1999 Liang, Y.C., Chen, Y.C., Lin, Y.L., Lin-Shiau, S.Y., Ho, C.T. and Lin, J.K.. Suppression of extracellular signals and cell proliferation by black tea polyphenol, theaflavin-3, 3-digallate. . Carcinogenesis .1999 ;(20):733-736

116. 1999 Hour, T.C., Liang, Y.C., Chu, I.S. and Lin, J.K.. Inhibition of eleven mutagens by various tea extracts, (-)-epigallocatechin-3-gallate and caffeine. . Food Chem. Toxico. .1999 ;(37):569-579

117. 1999 Lin, J.K., Liang, Y.C. and Lin-Shiau, S.Y.. Cancer chemoprevention by tea polyphenols through mitotic signal blockade, a commentary. . Biochem. Pharmacol .1999 ;(58):911-915

118. 1999 Tsai, S.H., Liang, Y.C., Lin-Shiau, S.Y. and Lin, J.K.. Myricetin inhibits IKK activity in ECV304 cells. . J. Cell. Biochem. .1999 ;(74):606-615

119. 1999 Chen, Y.C., Liang, Y.C., Lin-Shiau, S.Y. and Lin, J.K.. Inhibition of TPA-induced PKC and AP-1 binding activities by theaflavin-3,3-digallate from black tea in NIH3T3 cells. . J. Agri. Food Chem. .1999 ;(47):1416-1421

120. 1999 Liang, Y.C., Huang Y.T., Tsai S.H, Lin-Shiau S.Y., Chen C.F. and Lin J.K.. Suppression of inducible cyclooxygenase and inducible nitric oxide synthase by apigenin and related flavonoids in mouse macrophages. . Carcinogenesis .1999 ;(20):1945-1952

121. 1998 Lin, J.K., Lin, C.L., Liang, Y.C., Lin-Shiau, S.Y. and Juan, I.M.. Survey of Catechins, Gallic Acid and Methylxanthines in Green, Oolong, Pu-Erh and Black Teas. . J. Agri. Food Chem. .1998 ;(46):3635-3642

122. 1997 Liang, Y.C., Lin-Shiau, S.Y., Chen, C.F. and Lin, J.K.. Suppression of extracellular signals and cell proliferation through EGF receptor binding by (-)-epigallocatechin-3-gallate in human A 431 epidermoid carcinoma cells. . J. Cell. Biochem. .1997 ;(67):55-65

123. 1996 Lin, Y.L., Juan, I.M., Chen, Y.L., Liang, Y.C. and Lin, J.K.. Composition of polyphenols in fresh tea leaves and associations of their oxygen-radical-absorbing capacity with antiproliferative actions in fibroblast cells. . J. Agric. Food Chem. .1996 ;(44):1387-1394

124. 1995 Lee, S.F., Liang, Y.C. and Lin, J.K.. Inhibition of 1,2,4-benzenetriol-generated active oxygen species and induction of phase II enzymes by green tea polyphenols. . Chem. Biol. Interact. .1995 ;(98):283-301

會議論文 Conference Paper


1. 2008 Liang HJ,Chen NQ,Hung LF,Liang YC. NQ-1: a novel dual PPARa/r activator with potent hypoglycemic activity in db/db mice . .2008

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衛生福利部雙和醫院(委託臺北醫學大學興建經營)
計畫名稱
98 ATF3在大腸癌凋亡上的角色
補助單位
台北市立萬芳醫院委託財團法人私立臺北醫學大學辦理
計畫名稱
98 運用蛋白質體學技術探討蛋白酉每體抑制劑之抗癌機轉
補助單位
行政院國家科學委員會
計畫名稱
98 脂肪酸與葡萄糖誘導二肽基酶四表現之研究
補助單位
臺北縣立醫院
計畫名稱
97 一氧化碳誘導環氧化酶乙表現之分子機制探討
補助單位
奇美醫療財團法人奇美醫院
計畫名稱
97 開發小葉葡萄應用於預防神經退化疾病之功能研究(2-2)
補助單位
行政院農業委員會
計畫名稱
97 禽流感疫苗研發-禽流感疫苗佐劑之研發
補助單位
行政院農業委員會動植物防疫檢疫局
計畫名稱
96 重要動物畜禽疾病防治與監控計畫─利用免疫蛋白體學尋找兔化豬瘟疫苗株與野外獨立株抗原差異之研究
補助單位
行政院農業委員會動植物防疫檢疫局
計畫名稱
96 探討生長抑制因子四之腫瘤抑制分子機轉
補助單位
行政院國家科學委員會
計畫名稱
96 丹參抗癌作用之分子機制探討
補助單位
行政院國家科學委員會
計畫名稱
95 PPAR配體抑制CTGF表現之機制探討
補助單位
台北市立萬芳醫院委託財團法人私立臺北醫學大學辦理
計畫名稱
95 開發小葉葡萄應用於預防神經退化疾病之功能研究
補助單位
行政院農業委員會
計畫名稱
95 禽流感疫苗研發
補助單位
行政院農業委員會動植物防疫檢疫局
計畫名稱
95 生物可分解之專一性奈米黃金殼的開發及其在近紅外線熱治療腫瘤上之應用
補助單位
行政院國家科學委員會
計畫名稱
94 香菸中尼古丁致癌分子機制研究：尼古丁乙醯膽鹼受體及女性賀爾蒙協同促進乳房上皮細胞癌化之分子機制探討
補助單位
臺北醫學大學附設醫院
計畫名稱
94 前列腺素及熱休克因子影響血基素氧化酶表現之機制探討(2/2)漕丹化之作用機轉及其對大鼠蜘蛛網膜下腔出血後之保護作用評估I)
補助單位
行政院國家科學委員會
計畫名稱
94 微弧氧化二氧化鈦-磷灰石層對骨母細胞分化增生特性影響之研究
補助單位
行政院國家科學委員會
計畫名稱
94 動植物有害生物快速診斷鑑定技術之開發與應用
補助單位
行政院農業委員會動植物防疫檢疫局
計畫名稱
93 ING4突變及其調控機制之研究
補助單位
奇美醫療財團法人奇美醫院
計畫名稱
93 前列腺素及熱休克因子影響血基素氧化酶表現之機制探討(1/2)
補助單位
行政院國家科學委員會
計畫名稱
92 脂肪酸輔脢A接合脢四在花生四烯酸代謝及腫瘤形成上所扮演的角色
補助單位
行政院國家科學委員會
計畫名稱
92 LamisilR奈米載體(liposome)抗癌之訊號傳遞機制探討
補助單位
新光醫療財團法人新光吳火獅紀念醫院
計畫名稱
91 探討PPAR配位体抑癌作用及引起細胞分化之分子機制: 体外與体內試驗
補助單位
行政院國家科學委員會
計畫名稱
90 PPAR配位体之抗癌化及抗發炎作用機制
補助單位
行政院國家科學委員會
計畫名稱
89 篩選活化PPARγ之天然化物及其活化路徑之研究
補助單位
行政院國家科學委員會